The Additional Hetero Ring Consists Of Two Nitrogens And Three Carbons Patents (Class 514/341)
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Patent number: 9771328Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.Type: GrantFiled: January 23, 2017Date of Patent: September 26, 2017Assignee: GILEAD SCIENCES, INC.Inventor: Joshua R. Dunetz
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Patent number: 9708288Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.Type: GrantFiled: September 2, 2014Date of Patent: July 18, 2017Assignee: Dow AgroSciences LLCInventors: Ann M. Buysse, Noormohamed M. Niyaz, David A. Demeter, Yu Zhang, Martin J. Walsh, Asako Kubota, Ricky Hunter, Tony K. Trullinger, Christian T. Lowe, Daniel I. Knueppel, Akshay Patny, Negar Garizi, Paul Renee LePlae, Jr., Frank J. Wessels, Ronald Ross, Jr., Carl DeAmicis, Peter Borromeo
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Patent number: 9701657Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase enzymes. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: GrantFiled: September 11, 2015Date of Patent: July 11, 2017Assignee: Celgene Quanticel Research, Inc.Inventors: Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal
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Patent number: 9681658Abstract: An agrochemical formulation comprising a penetrant and an agrochemical active. The penetrant is an esterified and/or etherified polyol alkoxylate obtainable by directly esterifying and/or etherifying a polyol alkoxylate. There is also provided a method of making the penetrant comprising alkoxylation of a polyol, and esterification or etherification of the formed poyol alkoxylate. The penetrant is suitable for use in agrochemical formulations to enhance penetration of the active across a leaf cuticle.Type: GrantFiled: November 19, 2013Date of Patent: June 20, 2017Assignee: Croda International PLCInventors: Trevor Graham Blease, Kathryn Marie Knight
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Patent number: 9668480Abstract: The invention relates to the use of N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivatives and/or salts thereof for improving growth in crops, comprising preventively and/or curatively controlling resistant strains of fungi, particularly for controlling strains of fungi resistant to SDHI fungicides. The invention further relates to associated methods.Type: GrantFiled: October 17, 2013Date of Patent: June 6, 2017Assignee: BAYER CROPSCIENCE AGInventors: Pierre Cristau, Marie-Claire Grosjean-Cournoyer, Anne Lappartient, Andreas Mehl, Valerie Toquin, Francois Villalba
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Patent number: 9648879Abstract: A co-crystal composed of a diamide-based insecticidal-active ingredient and a neonicotinoid-based insecticidal-active ingredient is provided as a co-crystal which exhibits excellent insecticidal effects over a long period of time while reducing the occurrence of chemical damage on useful plants. The co-crystal is obtained by a method including heating and stirring of a suspension obtained by suspending the diamide-based insecticidal-active ingredient and the neonicotinoid-based insecticidal-active ingredient in a solvent such as water.Type: GrantFiled: October 31, 2014Date of Patent: May 16, 2017Assignee: Nippon Soda Co., Ltd.Inventors: Akihiko Ito, Tomohiro Amano, Rieko Masaki
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Patent number: 9643953Abstract: Compounds of formula (I) and their use as pharmaceutical.Type: GrantFiled: December 17, 2012Date of Patent: May 9, 2017Assignees: BAYER INTELLECTUAL PROPERTY GMBH, BAYER PHARMA AKTIENGESELLSCHAFTInventors: Marion Hitchcock, Anne Mengel, Anja Richter, Hans Briem, Knut Eis, Vera Pütter, Gerhard Siemeister, Stefan Prechtl, Amaury Ernesto Fernández-Montalván, Christian Stegmann, Simon Holton, Mark Jean Gnoth, Cornelia Preuβe
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Patent number: 9616044Abstract: The present invention relates to a long-acting composition for the treatment of an animal in need thereof wherein the composition includes a therapeutically effective amount of a bioactive agent, characterized in that the composition includes a non-aqueous carrier and a solvent system comprising castor oil and at least one cyclic amide.Type: GrantFiled: March 13, 2013Date of Patent: April 11, 2017Inventors: Fadil Al Alawi, Karthigeyan Nanjan
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Patent number: 9598361Abstract: An amino substituted acetamide derivative can include a compound having the following general formula: wherein R represents (4-Cyano-4-phenyl)piperidinyl hydrochloride, (4-Hydroxy-4-phenyl)piperidine, (4-chlorophenyl)piperidine hydrochloride, 4-Piperidinopiperidine, 4-(Methoxyphenyl)piperidine, 1-(2,3-xylyl)piperazine monohydrochloride, 4-Aminoquinaldine or anthranilic acid, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 12, 2016Date of Patent: March 21, 2017Assignee: KING SAUD UNIVERSITYInventors: Amani Shafeek Awaad, Ahmed Mahmoud Ahmed Alafeefy, Reham Mostafa El-Meligy
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Patent number: 9556207Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.Type: GrantFiled: October 29, 2014Date of Patent: January 31, 2017Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENTInventors: Craig C. Beeson, Christopher C. Lindsey, Yuri K. Peterson, Baerbel Rohrer
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Patent number: 9549560Abstract: A pesticidal composition comprises at least one compound selected from a 1-(3-pyridyl-N-oxide) pyrazole compound of formula I, II, or III, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R12, R13, Y, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.Type: GrantFiled: October 17, 2014Date of Patent: January 24, 2017Assignee: Dow AgroSciences LLCInventors: Martin J. Walsh, Daniel Knueppel, Noormohamed M. Niyaz, Ann M. Buysse, Negar Garizi, Asako Kubota, Yu Zhang, Ricky Hunter, Tony K. Trullinger
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Patent number: 9518026Abstract: The present disclosure is generally directed to compositions and methods for treating apicomplexan protozoan related disease, such as toxoplasmosis and cryptosporidiosis.Type: GrantFiled: May 20, 2014Date of Patent: December 13, 2016Assignee: University of Washington Through its Center For CommercializationInventors: Erkang Fan, Wesley C. Van Voorhis, Zhongsheng Zhang, Wenlin Huang, Kayode K. Ojo
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Patent number: 9510596Abstract: The present invention relates to novel mixtures, to processes for preparing these compounds, to compositions comprising these mixtures, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms or pests in crop protection and in the protection of materials and for enhancing plant health.Type: GrantFiled: November 27, 2013Date of Patent: December 6, 2016Assignee: BAYER CROPSCIENCE AGInventors: Haruko Sawada, Stefan Herrmann, Heiko Rieck, Christophe Dubost
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Patent number: 9510595Abstract: The present invention relates to pesticidal mixtures comprising a component A and a component B, wherein component A is a compound of formula (I) R2 is group X wherein A is A1 or A2 and X1, X2, X3, B1, B2, B3, Y1, Y2, Y3, Z, k, R1 and R5 are as defined in claim 1 and component B is an insecticide. The present invention also relates to methods of using said mixtures for the control of plant pests.Type: GrantFiled: October 9, 2013Date of Patent: December 6, 2016Assignee: Syngenta Participations AGInventors: Jerome Yves Cassayre, Myriem El Qacemi
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Patent number: 9512120Abstract: The present invention provides compounds of formula (I) wherein Y1, Y2, Y3, G, V1, V2, V3 and V4 are as defined in the claims. The invention further relates to compositions which comprise these compounds and to their use in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.Type: GrantFiled: March 17, 2014Date of Patent: December 6, 2016Assignee: Syngenta Participations AGInventors: Kurt Nebel, Martin Pouliot
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Patent number: 9499490Abstract: The present invention provides a compound of the Formula: wherein X is selected from the group consisting of, R is selected from the group consisting of H and CH3; R1 is selected from the group consisting of H, CH3, F, Cl, OCH3, C(O)OH, C(O)NH2 or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2014Date of Patent: November 22, 2016Assignee: Eli Lilly and CompanyInventors: Kevin Kun-Chin Liu, Yinong Xie, Liang Wu, Guoqiang Zhou
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Patent number: 9497967Abstract: A pesticidal composition comprises a synergistically effective amount of a chloride channel activator compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio) propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl) sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by pests comprises contacting the plant with the synergistic pesticidal composition.Type: GrantFiled: May 28, 2015Date of Patent: November 22, 2016Assignee: Doe AgroSciences LLCInventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak, John Herbert
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Patent number: 9493449Abstract: The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: R10 Z-HET-E I-A and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R10 and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.Type: GrantFiled: March 13, 2014Date of Patent: November 15, 2016Assignee: Purdue Pharma L.P.Inventors: Jiangchao Yao, Laykea Tafesse
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Patent number: 9485989Abstract: The invention relates to a method of controlling insects from the order hemiptera that resistant to neo-nicotinoid insecticides using spiroheterocyclic pyrrolidine dione derivatives.Type: GrantFiled: May 26, 2011Date of Patent: November 8, 2016Assignee: Syngenta Participations AGInventors: Russell Slater, Alfred Rindlisbacher, Peter Maienfisch, Phillippe Camblin, Alain Gaume
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Patent number: 9457019Abstract: The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravazation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of Formula I.Type: GrantFiled: November 7, 2014Date of Patent: October 4, 2016Assignee: Deciphera Pharmaceuticals, LLCInventors: Daniel L. Flynn, Michael D. Kaufman, Bryan D. Smith, Marc Rudoltz
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Patent number: 9457084Abstract: This invention relates to a compound with EP4 antagonistic activity, or a pharmaceutically acceptable salt with EP4 receptor antagonistic activities, which is useful in the treatment of immune disease or allergy. This invention also relates to a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof with EP4 receptor antagonistic activities, which is useful in the treatment of immune disease or allergy. This invention also relates to a pharmaceutical composition for the treatment of immune disease or allergy which comprises a therapeutically effective amount of a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 22, 2011Date of Patent: October 4, 2016Assignee: RAQUALIA PHARMA INC.Inventors: Kiyoshi Kanazawa, Kazuhiko Nonomura, Takako Okumura, Shinichi Koizumi
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Patent number: 9458139Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.Type: GrantFiled: March 15, 2013Date of Patent: October 4, 2016Assignee: Global Blood Therapeutics, Inc.Inventors: Qing Xu, Zhe Li, Brian W. Metcalf
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Patent number: 9445593Abstract: This invention provides a method for soil systemic control of an invertebrate pest by contacting the soil with a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure.Type: GrantFiled: July 15, 2015Date of Patent: September 20, 2016Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
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Patent number: 9422268Abstract: Compounds of formula (I) and their use as pharmaceutical.Type: GrantFiled: December 17, 2012Date of Patent: August 23, 2016Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Marion Hitchcock, Anne Mengel, Anja Richter, Hans Briem, Knut Eis, Vera Pütter, Gerhard Siemeister, Stefan Prechtl, Amaury Ernesto Fernández-Montalván, Christian Stegmann, Simon Holton, Mark Jean Gnoth, Cornelia Preuβe
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Patent number: 9416123Abstract: Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases. Said method is effective and can be provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.Type: GrantFiled: March 28, 2014Date of Patent: August 16, 2016Assignee: Synovo GmbHInventors: Michael William Burnet, Bassam Abu Thaher, Jan Ehlert, Michael Kubbutat, Christoph Schaechtele, Frank Totzke
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Patent number: 9414595Abstract: The present invention relates to the use of anthranilic acid diamide derivatives with heteroaromatic and heterocyclic substituents of formula (I) wherein R1, R2, R3, R4, R5, R6, n, A, Q have the meanings as given in the description—for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and to methods particularly useful for controlling insects, and/or acarids and/or nematodes and/or increasing crop yield in those crops.Type: GrantFiled: December 17, 2012Date of Patent: August 16, 2016Assignees: Bayer CropScience AG, Bayer Intellectual Property GmbHInventors: Rüdiger Fischer, Heike Hungenberg, Bill Striegel, Steven Riniker
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Patent number: 9408390Abstract: Insecticide compositions which comprise one or not less than two kinds of compounds being selected from a compound represented by the formula [I]: or a salt thereof, and a neonicotinoid compound represented by the formula [II]: The insecticide compositions can produce higher insecticidal effects than would be expected when each of the active ingredients is used singly, namely a synergistic effect, thus enabling reductions in the rate or number of application of agrochemicals and pesticides to be realized.Type: GrantFiled: June 22, 2015Date of Patent: August 9, 2016Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Yuichi Ohkawara
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Patent number: 9365543Abstract: N-Thio-anthranilamid compounds of formula (I) wherein A is A1 wherein the variables and the indices are as defined per the description, processes for preparing the compounds I, pesticidal compositions comprising compounds I, use of compounds I for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of formula I.Type: GrantFiled: June 15, 2015Date of Patent: June 14, 2016Assignee: BASF SEInventors: Thomas Schmidt, Michael Puhl, Joachim Dickhaut, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Douglas D. Anspaugh, Franz-Josef Braun, Toni Bucci, Henry Van Tuyl Cotter, David G. Kuhn, Hassan Oloumi-Sadeghi
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Patent number: 9358225Abstract: Ataxia-telangiectasia (A-T) is a progressive degenerative disorder that results in major neurological disability. In A-T patients, necropsy has revealed atrophy of all cerebellar cortical layers with extensive Purkinje and granular cell loss. We have previously identified an increase in phospho-p38MAPK levels, which was accompanied by downregulation of Bmi-1 and upregulation of p21, as key components of the mechanism causing defective proliferation of neural stem cells (NSCs) isolated from subventricular zone (SVZ) of Atm-null mice. Our results demonstrate that restoration of NSCs by pharmacologic inhibition of p38MAPK signaling has the potential to treat neurological defects of A-T. This study provides new insights into the therapeutic strategy targeting NSCs rather than replacing impaired neurons not only for A-T, but for other neurodegenerative disorders as well.Type: GrantFiled: March 17, 2014Date of Patent: June 7, 2016Assignee: Bach Pharma, Inc.Inventor: Paul K. Y. Wong
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Patent number: 9315498Abstract: The present invention relates to ethynyl compounds of formula I-C1 wherein R1, R2, R2?, R3, R3?, R6, U, V and W are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof, which are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Type: GrantFiled: November 20, 2013Date of Patent: April 19, 2016Assignee: HOFFMAN-LA ROCHE INC.Inventors: Luke Green, Wolfgang Guba, Georg Jaeschke, Synese Jolidon, Lothar Lindemann, Antonio Ricci, Daniel Rueher, Heinz Stadler, Eric Vieira
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Patent number: 9301532Abstract: The invention relates to active compound combinations, in particular a fungicidal and/or insecticidal composition, comprising Isotianil (3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide) and at least one further insecticide of the anthranilamide group and optionally one further insecticide of the neonicotinoids. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi and/or microorganisms and/or pests of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.Type: GrantFiled: October 9, 2014Date of Patent: April 5, 2016Assignee: Bayer Intellectual Property GmbHInventors: Lutz Assmann, Ulrike Wachendorff-Neumann, Peter Dahmen, Heike Hungenberg, Wolfgang Thielert
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Patent number: 9295258Abstract: A pesticidal composition comprises a synergistically effective amount of an ecdysone receptor agonist compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio)propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by insects comprises contacting the plant with the synergistic pesticidal composition.Type: GrantFiled: October 17, 2014Date of Patent: March 29, 2016Assignee: Dow AgroSciences LLCInventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak
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Patent number: 9260412Abstract: Compounds of formula (I) and their use as pharmaceutical.Type: GrantFiled: December 17, 2012Date of Patent: February 16, 2016Assignees: BAYER INTELLECTUAL PROPERTY GMBH, BAYER PHARMA AKTIENGESELLSCHAFTInventors: Marion Hitchcock, Anne Mengel, Anja Richter, Hans Briem, Knut Eis, Vera Pütter, Gerhard Siemeister, Stefan Prechtl, Amaury Ernesto Fernández-Montalván, Christian Stegmann, Simon Holton, Mark Jean Gnoth, Cornelia Preuβe
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Patent number: 9242961Abstract: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.Type: GrantFiled: October 3, 2013Date of Patent: January 26, 2016Assignee: Amgen Inc.Inventors: Victor J. Cee, Karina Romero
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Patent number: 9232797Abstract: A pesticidal composition comprising a carboxamide compound represented by following formula (A), wherein R1 represents a hydrogen atom or a methyl group, and R2 represents a methyl group, a difluoromethyl group or a trifluoromethyl group, and a diamide compound represented by following formula (B), wherein X1, X2, X3, X4 and X5 have the same meanings as defined in the specification, is provided by the present invention, and this composition has an excellent pesticidal effect.Type: GrantFiled: April 25, 2011Date of Patent: January 12, 2016Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Yuichi Matsuzaki
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Patent number: 9192604Abstract: This invention relates to a method of treating cancer in a human in need thereof by determining the presence or absence of a detectable amount of a gene product of the Neurofibromin-2 (NF2) gene in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected. This invention also relates to a method of treating cancer in a human in need thereof, comprising determining the presence or absence of a detectable amount of a functional isoform 1 protein of the NF2 gene, or a functional fragment thereof, in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected.Type: GrantFiled: June 28, 2012Date of Patent: November 24, 2015Assignee: GlaxoSmithKline Intellectual Property (No. 2) LimitedInventors: Kurt R. Auger, Mohammed M. Dar, Ronald A. Fleming
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Patent number: 9173403Abstract: This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.Type: GrantFiled: April 1, 2011Date of Patent: November 3, 2015Assignee: MERIAL, INC.Inventors: Joseph K. Rosentel, Jr., Monica Tejwani, Arima Das-Nandy
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Patent number: 9161540Abstract: This invention provides compounds of Formula 1, N-oxides and suitable salts thereof wherein R1 is Me, Cl, Br or F; R2 is F, Cl, Br, C1-C4 haloalkyl or C1-C4 haloalkoxy; R3 is F, Cl or Br; R4 is H; C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C5 cycloalkyl, or C4-C6 cycloalkylalkyl, each optionally substituted with one substituent selected from the group consisting of halogen, CN, SMe, S(O)Me, S(O)2Me, and OMe; R5 is H or Me; R6 is H, F or Cl; and R7 is H, F or Cl. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula 1, an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein).Type: GrantFiled: March 11, 2013Date of Patent: October 20, 2015Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Kenneth Andrew Hughes, George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
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Patent number: 9155304Abstract: A pesticidal composition comprises a synergistically effective amount of a chloride channel activator compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-((3,3,3-trifluoropropyl)thio) propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-((3,3,3,3-trifluoropropyl) sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by pests comprises contacting the plant with the synergistic pesticidal composition.Type: GrantFiled: October 17, 2014Date of Patent: October 13, 2015Assignee: Dow AgroSciences LLCInventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak, John Herbert
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Patent number: 9149040Abstract: A pesticidal composition comprises a synergistically effective amount of a flonicamid-based selective homopteran feeding blocker compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio)propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl) sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by pests comprises contacting the plant with the synergistic pesticidal composition.Type: GrantFiled: October 17, 2014Date of Patent: October 6, 2015Assignee: Dow AgroSciences LLCInventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak
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Patent number: 9150545Abstract: The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.Type: GrantFiled: March 14, 2013Date of Patent: October 6, 2015Assignees: AbbVie Deutschland GmbH & Co. KG, AbbVie Inc.Inventors: Andreas Kling, Katja Jantos, Helmut Mack, Achim Möller, Wilfried Hornberger, Gisela Backfisch, Yanbin Lao, Marjoleen Nijsen
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Patent number: 9144241Abstract: A pesticidal composition comprises a synergistically effective amount of an acetyl CoA carboxylase inhibitor compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio)propanamide (I), N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by insects comprises contacting the plant with the synergistic pesticidal composition.Type: GrantFiled: October 17, 2014Date of Patent: September 29, 2015Assignee: Dow AgroSciences LLCInventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak
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Patent number: 9137995Abstract: The invention relates to novel compositions for controlling parasites on animals, comprising an N-arylpyrazole and also a pyrethroid in a formulation comprising aliphatic cyclic carbonates and aliphatic cyclic or acyclic polyethers.Type: GrantFiled: October 27, 2011Date of Patent: September 22, 2015Assignee: Bayer Intellectual Property GmbHInventors: Kirkor Sirinyan, Andreas Turberg
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Patent number: 9095137Abstract: Insecticide compositions which comprise one or not less than two kinds of compounds being selected from a compound represented by the formula [I]: or a salt thereof, and a neonicotinoid compound represented by the formula [II]: The insecticide compositions can produce higher insecticidal effects than would be expected when each of the active ingredients is used singly, namely a synergistic effect, thus enabling reductions in the rate or number of application of agrochemicals and pesticides to be realized.Type: GrantFiled: February 21, 2005Date of Patent: August 4, 2015Assignee: SUMITOMO CHEMICAL COMPANY LIMITEDInventor: Yuichi Ohkawara
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Patent number: 9095136Abstract: The present invention relates to novel 2-iodoimidazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.Type: GrantFiled: November 23, 2012Date of Patent: August 4, 2015Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Hendrik Helmke, Sebastian Hoffmann, Carl Friedrich Nising, Alexander Sudau, Tomoki Tsuchiya, Jürgen Benting, Peter Dahmen, Ulrike Wachendorff-Neumann, David Bernier, Stephane Brunet, Marie-Claire Grosjean-Cournoyer, Hélène Lachaise, Philippe Rinolfi
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Patent number: 9084422Abstract: This invention provides a compositions and methods of using biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure, to protect genetically modified plants and their environment. An effective amount of at least one additional biological agent can be combined with the compound of Formula 1.Type: GrantFiled: July 22, 2013Date of Patent: July 21, 2015Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
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Patent number: 9051278Abstract: The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g.Type: GrantFiled: May 19, 2014Date of Patent: June 9, 2015Assignee: ASTEX THERAPEUTICS, LTD.Inventors: Valerio Berdini, Michael Alistair O'Brien, Maria Grazia Carr, Theresa Rachel Early, Adrian Liam Gill, Gary Trewartha, Alison Jo-Anne Woolford, Andrew James Woodhead, Paul Graham Wyatt
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Patent number: 9049861Abstract: This invention provides a composition comprising a first compound selected from Formula 1, an N-oxide or an agriculturally suitable salt thereof; and a second compound selected from insecticidal macrocyclic lactones, wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure.Type: GrantFiled: March 8, 2013Date of Patent: June 9, 2015Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
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Patent number: 9044016Abstract: The present invention relates to N-thio-anthranilamide compounds of the formula (I), the stereoisomers, the salts, the tautomers and the N-oxides thereof, wherein R1 is halogen or halomethyl; R2 is hydrogen, halogen or cyano; R3 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, C2-C6-alkenyl or the like; R4 is halogen; R5 and R6 independently of each other are optionally substituted C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, phenyl, or together represent an (hetero)aliphatic chain, or the like; k is 0 or 1.Type: GrantFiled: August 10, 2012Date of Patent: June 2, 2015Assignee: BASF SEInventors: Florian Kaiser, Karsten Körber, Prashant Deshmukh, Deborah L. Culbertson, Paul Neese, Koshi Gunjima
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Publication number: 20150148381Abstract: The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.Type: ApplicationFiled: February 4, 2015Publication date: May 28, 2015Inventors: Kai THEDE, Ingo FLAMME, Felix OEHME, Jens-Kerim ERGÜDEN, Friederike STOLL, Joachim SCHUHMACHER, Hanno WILD, Peter KOLKHOF, Hartmut BECK, Jörg KELDENICH, Metin AKBABA, Mario JESKE