Chitin Or Derivative Patents (Class 514/55)
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Patent number: 9029350Abstract: This invention relates to the use of a biomaterial for the treatment, repair and/or enhancement of bodily tissue insufficiencies of the vocal chords, muscles, ligaments, cartilage, post-operative regions, sexual organs and/or weight supporting areas of the feet as well as other conditions of the bones and joints. The biomaterial for use in the invention may comprise an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to the use of a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. The invention also includes the use of various medicaments in the biomaterial formulations to enhance the treatment of the affected area of the body.Type: GrantFiled: April 24, 2013Date of Patent: May 12, 2015Assignee: Cutanea Life Sciences, Inc.Inventors: Robert J. Bitterman, Kimberley A. Forbes-McKean
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Patent number: 9029351Abstract: The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds.Type: GrantFiled: January 13, 2014Date of Patent: May 12, 2015Assignee: Synedgen, Inc.Inventors: Shenda M. Baker, William P. Wiesmann
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Patent number: 9029349Abstract: The invention provides a bioadhesive composition comprising a polysaccharide and an energy converter, wherein the energy converter is activated by non-UV light. The composition may be prepared by dissolving the polysaccharide and the energy converter in an aqueous acidic solution. The composition, in the form of a film or a gel, may be used for repairing a discontinuity in an area of tissue or for joining tissue.Type: GrantFiled: August 26, 2005Date of Patent: May 12, 2015Inventors: Antonio Lauto, Laura Poole-Warren, Leslie John Ray Foster
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Publication number: 20150125513Abstract: Improved hemostatic agents take the form of granules or particles that can be used to stanch, seal, or stabilize a site of hemorrhage, including a noncompressible hemorrhage.Type: ApplicationFiled: January 5, 2015Publication date: May 7, 2015Inventor: Simon J. McCarthy
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Patent number: 9023404Abstract: The present invention intends to provide a composition for hair and skin treatment containing a combination consisting of silk amino acid and protein complexes, seed oils, polysaccharides, polyol, monosaccharide, and botanicals. The composition for hair and skin treatment containing the combination consisting of silk amino acid and protein complexes, seed oils, polysaccharides, and botanicals has excellent improvement effects on the condition of the hair follicle and cuticle, imparts moisture to dry hair; thereby reducing the damaging effects of psoriasis, eczema, alopecia, and seborrheic dermatitis. Furthermore, it imparts retention of moisture to the skin resulting in an improved appearance and diminished appearance of lines on the skin. This invention relates to the manufacture of personal care products to be applied to the hair and skin. The compositions may be in the form of hair conditioners, hair growth treatments, shampoos, skin care, skin cleansing, or anti-wrinkle products, and ointments.Type: GrantFiled: January 23, 2011Date of Patent: May 5, 2015Inventor: Valerie Marie Ross
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Patent number: 9023829Abstract: A method of decreasing NFATc2 activity in a lymphocyte includes administering to the lymphocyte an amount of an NFATc2 mRNA antagonist that binds to a binding site on the 3?UTR of NFATc2 mRNA effective to decrease the activity of NFATc2 mRNA in the lymphocyte.Type: GrantFiled: March 14, 2011Date of Patent: May 5, 2015Assignee: Case Western Reserve UniversityInventor: Mary J. Laughlin
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Publication number: 20150119358Abstract: A method for treating a wound with a ready-to-use composition having a high concentration of a water-soluble chitosan in a phosphate-containing solution. The composition is a paste at room temperature, has a pH of at least 4, adheres to the body tissue or surgical site and has a residence time of at least 1 day.Type: ApplicationFiled: June 30, 2014Publication date: April 30, 2015Inventors: Jennifer Gates Medina, Ethan Glenn Sherman
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Publication number: 20150119357Abstract: Nasal or sinus site may be treated with a ready-to-use paste having a high concentration of a water-soluble chitosan, an osmolality reducing agent in a phosphate-containing solution. The paste forms at room temperature, has a pH of at least 4 and the osmolality reducing agent does not crosslink with the water-soluble chitosan. The paste provides stenting and adheres to the nasal or sinus site and has a residence time of at least 1 day.Type: ApplicationFiled: October 24, 2013Publication date: April 30, 2015Applicant: Medtronic Xomed, Inc.Inventors: Jennifer Gates Medina, Ethan Glenn Sherman
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Patent number: 9018372Abstract: The invention relates to a bonding product comprising at least the polysaccharides T1 and T2, characterized in that a) the monosaccharides from which the polysaccharides T1 and T2 are constructed are partially or completely bonded to each other alpha-1,4-glycosidically and b) at least one of the polysaccharides T1 and/or T2 comprises at least one amino group and c) T1 and T2 are chemically bonded to each other covalently by at least one linker Z and d) T1 and/or T2 carries m groups -(L-A), wherein A is an active pharmaceutical ingredient and/or a fluorescence label, L is a second linker, by which T1 and/or T2 is covalently bonded to A, and m is an integer, which is 0 or at least 1.Type: GrantFiled: March 31, 2010Date of Patent: April 28, 2015Assignee: B. Braun Melsungen AGInventors: Bernd Horst Meier, Iris Jankowiak-Meier, Nele Meier, Clara Meier
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Patent number: 9012429Abstract: The present invention is directed to the treatment and prevention of nosocomial infections or MRSA infections utilizing soluble chitosan or chitosan derivative compounds. These chitosan-derivative compounds, e.g., chitosan-arginine and chitosan-acid amines, exhibit bactericidal activity against bacterial pathogens, e.g., drug resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA).Type: GrantFiled: August 14, 2009Date of Patent: April 21, 2015Assignee: Synedgen, Inc.Inventors: Shenda Baker, William P. Wiesmann
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Patent number: 8999951Abstract: The present invention provides method of optimizing the efficacy and potency of antisense drugs. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipients for improved cellular uptake.Type: GrantFiled: October 23, 2012Date of Patent: April 7, 2015Assignee: Isis Pharmaceuticals, Inc.Inventors: Erich Koller, C. Frank Bennett
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Patent number: 8993539Abstract: The present invention provides a composition of dietary fiber supplements for satiety enhancement and appetite suppression in treatment of overweight, obesity, or eating disorders. The composition of the dietary fiber supplements consist of at least one cationic polymer and at least one anionic polymer. The cationic polymers and the anionic polymers in the composition can be dissolved or dispersed in an aqueous solution. When the pH of the aqueous solution is lowered, such as the solution is ingested into the stomach with a gastric pH environment or the aqueous solution is added with some acidifying agents, the aqueous solution will turn into a gel. The formation of a gel from the aqueous solution after it being ingested into the stomach before a meal would provide a satiety enhancement and appetite suppression effect.Type: GrantFiled: September 22, 2013Date of Patent: March 31, 2015Inventor: Guang Yan
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Patent number: 8993540Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).Type: GrantFiled: March 16, 2010Date of Patent: March 31, 2015Assignee: University of Memphis Research FoundationInventors: Warren O. Haggard, Scott P. Noel, Joel D. Bumgardner
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Patent number: 8987230Abstract: The present invention provides a composition comprising a hyaluronic acid derivative having a crosslinking group(s) and a hydrophilic polysaccharide derivative having a hydrophobic group(s), wherein the hyaluronic acid derivative having a crosslinking group(s) is prepared by crosslinkage formation reaction in hyaluronic acid or a derivative thereof having a crosslinkable group(s) in the presence of the hydrophilic polysaccharide derivative wherein the hydrophilic polysaccharide derivative may have a crosslinkable group(s).Type: GrantFiled: April 30, 2008Date of Patent: March 24, 2015Assignees: National University Corporation Tokyo Medical and Dental University, Chugai Seiyaku Kabushiki KaishaInventors: Kazunari Akiyoshi, Nobuyuki Morimoto, Tai Hirakura, Tsuyoshi Shimoboji
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Publication number: 20150079141Abstract: Described is a homogeneous gel composition with at least antimicrobial, antibacterial, and/or anti-viral properties comprising; a combination of a stable and homogeneous aqueous and/or polyol solution based chelated metal oxide liquid complex suspension and a gel composition free of chelated metal oxides comprising water, polyquaternium, glycerine and hyaluronic acid, wherein the homogeneous gel composition contains chelated metal oxide particles homogeneously suspended in the homogeneous gel composition such that a concentration of the chelated metal oxide particles contained within the homogeneous gel are in a concentration of at least 0.001 weight percent.Type: ApplicationFiled: November 14, 2014Publication date: March 19, 2015Inventor: William Wingfield
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Publication number: 20150078995Abstract: A nanotheranostic probe and its use to facilitate diagnoses, treatment and targeting of amyloid deposits are disclosed herein.Type: ApplicationFiled: September 16, 2014Publication date: March 19, 2015Inventor: Karunya K. Kandimalla
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Publication number: 20150080335Abstract: The present invention relates to a process for producing a low endotoxin alkali chitosan, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan with an alkali solution to form a mixture and leaving the mixture for at least about 12 hours. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products.Type: ApplicationFiled: March 25, 2013Publication date: March 19, 2015Inventors: June Gladman, Craig Hardy, Andrew Hoggarth
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Publication number: 20150072013Abstract: A hydrogel bead for intra-articular supplement made by: providing a solution of alginate, providing a solution with chitosan having a Mw between lower than 60 kD, mixing the solution of alginate and the solution of chitosan, wherein the mixed solution comprises between 0.5 and 0.7% (w/v) of chitosan and between 1 and 1.4% alginate (w/v), introducing droplets of the mixed solution into a solution with Ca2+ or Sr2+ cations and isolating polymerised beads from the solution with cations.Type: ApplicationFiled: November 14, 2014Publication date: March 12, 2015Inventors: Yves Henrotin, Christelle Sanchez, Frederic Oprenyeszk, Pierre Drion
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Patent number: 8975387Abstract: Compositions of matter are provided that include chitosan and a modified carbohydrate. The modified carbohydrate includes a carbohydrate component and a cross linking agent. The modified carbohydrate has increased carboxyl content as compared to an unmodified counterpart carbohydrate. A carboxyl group of the modified carbohydrate is covalently bonded with an amino group of chitosan. The compositions of matter provided herein may include cross linked starch citrate-chitosan and cross linked hemicellulose citrate-chitosan, including foams thereof. These compositions yield excellent absorbency and metal chelation properties. Methods of making cross linked modified carbohydrate-chitosan compounds are also provided.Type: GrantFiled: March 21, 2011Date of Patent: March 10, 2015Assignee: North Carolina State UniversityInventors: Richard A. Venditti, Joel J. Pawlak, Abdus Salam, Khaled Fathy El-Tahlawy
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Publication number: 20150065454Abstract: The present invention relates to a homogeneous aqueous solution of injectable chitosan containing a chitosan having a degree of acetylation lower than 20%, said solution containing between 0.1 and 3.5% by weight of chitosan, said solution presenting a pH lower than 6.2, and said aqueous solution being capable of forming crystalline particles of chitosan after injection. The present invention also relates to compounds containing such a homogeneous aqueous solution of chitosan. The invention also relates to such compounds for their use as dermatological or cosmetic compounds, or for their use as a medical device, advantageously as a bioresorbable implant.Type: ApplicationFiled: November 30, 2012Publication date: March 5, 2015Inventors: Florence Dupasquier, Laurent David, Thierry Delair
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Patent number: 8951991Abstract: Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behavior with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behavior renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.Type: GrantFiled: May 21, 2007Date of Patent: February 10, 2015Assignee: Universita Degli Studi di TriesteInventors: Sergio Paoletti, Ivan Donati, Eleonora Marsich
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Patent number: 8951565Abstract: Improved hemostatic agents take the form of granules or particles that can be used to stanch, seal, or stabilize a site of hemorrhage, including a noncompressible hemorrhage.Type: GrantFiled: April 17, 2014Date of Patent: February 10, 2015Assignee: HemCon Medical Technologies, Inc.Inventor: Simon J. McCarthy
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Publication number: 20150018306Abstract: A self-regenerating chitosan based filter medium for disinfecting and purifying organic pollutants and other pollutants in a gas or liquid is disclosed herein. Porosity and surface charge of said filter medium is manipulative/tunable by varying one or more of the following parameter(s): concentration of chitosan, crosslinking density, amount of copolymers and additives, freezing temperature, freezing profile, and/or types of crosslinker used. The present filter medium is capable of self-regenerating under exposure to ultra-violet light for sufficient time and removing over 90% of the pollutants from each influent flowing through the filter medium.Type: ApplicationFiled: September 30, 2014Publication date: January 15, 2015Inventors: Jifan LI, Yee Man HO, Ka Chun LEE, Wai Yan CHAN, Mui CHAN, Kai Ming YEUNG
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Publication number: 20150018748Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.Type: ApplicationFiled: January 17, 2013Publication date: January 15, 2015Applicant: IMMUNOPHOTONICS, INC.Inventors: Tomas Hode, Robert E. Nordquist, Wei R. Chen, Raoul Carubelli, Luciano Alleruzzo, Peter Jenkins, Kristopher Waynant, Joseph Raker
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Publication number: 20150011503Abstract: A hemostatic dressing and method for manufacturing the same are disclosed. The hemostatic dressing comprises 25%-50% by weight of acidic chitosan fiber and 50%-75% by weight of crosslinked chitosan matrix. The hemostatic dressing of the present invention has better hemostasis effect and can maintain high stress intensity when be used.Type: ApplicationFiled: May 12, 2014Publication date: January 8, 2015Applicant: BENQ MATERIALS CORPORATIONInventor: KUO-YUNG CHANG
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Publication number: 20150011504Abstract: Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.Type: ApplicationFiled: July 23, 2014Publication date: January 8, 2015Inventors: Glen Gong, Suresh Subraya Pai, Scott Robert Sershen
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Publication number: 20140377187Abstract: A sclerosing embolizing hydrogel comprising from about 0.1% by weight to about 4.0% by weight of chitosan; from about 0.01 M to about 1 M of hydrochloric acid; from 0% by volume to about 40% by volume of iopamidol; from 0.5% by weight to about 25% by weight of ?-glycerophosphate disodium salt; and from about 0.05% by weight to about 4% by weight of sodium tetradecyl sulphate. Also a kit for synthesizing the hydrogel and a method using the hydrogel to treat a vascular defect in a subject.Type: ApplicationFiled: September 11, 2014Publication date: December 25, 2014Inventors: Sophie Lerouge, Giles Soulez, Ahmed Fatimi, Jean-Michel Coutu, Jean Raymond
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Publication number: 20140377368Abstract: The present invention pertains to chitosan beads consisting of chitosan cross-linked with citrate ions. The present invention furthermore pertains to a filler comprising such chitosan-citrate beads. In one embodiment of the instant invention the filler is a dermal filler. In one further embodiment of the present invention the dermal filler is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler is for use in the treatment of a medical condition. The filler provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler as claimed herein.Type: ApplicationFiled: September 9, 2014Publication date: December 25, 2014Inventors: Kevin Kiehm, Bernhard Hauptmeier, Peter Boderke
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Publication number: 20140377331Abstract: The present invention relates to an antimicrobial wound dressing comprising chitosan-silver nanoparticles and a preparation method thereof The antimicrobial wound dressing is prepared by coating a wound dressing with chitosan and silver and drying the coated wound dressing and has an excellent property of releasing silver nanoparticles in a sustained manner.Type: ApplicationFiled: December 28, 2012Publication date: December 25, 2014Inventors: Hyun Seung Ryu, Jun Kyu Park, Jun Hyuk Seo, Young Koo Lee
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Publication number: 20140378413Abstract: Modified chitosan hemostatic agents include reverse micelles (10) having an outer hydrophobic shell (12) of suitable biocompatible hydrophobic components such as alkanes, and hydrophilic positively charged chitosan moieties (14) enclosed within the hydrophobic shell (12). The hydrophobic shell (12) may be formed by attaching hydrophobic moieties to one end of chitosan polymer molecules while retaining sufficient reactive (positively charged) amine groups on the remainder of the chitosan polymers for effective blood clotting. The resulting reverse micelles (10) have the capability of penetrating mucous membranes such as nasal mucosa (20) or otherwise penetrating to bleed sites shielded or partially shielded by mucosa or other tissues.Type: ApplicationFiled: September 5, 2014Publication date: December 25, 2014Inventors: Dean A. Berman, Joseph Bristow
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Patent number: 8916182Abstract: A ‘bioactive’ composition that has one or more oligogalacturonans ((1?4)-?-D-galacturonan) or any other oligosaccharides (oligoguluronans) that may present an ‘egg box’ conformation, this conformation being further stabilized by one or more polycationic saccharide(s), preferably either a chitosan oligosaccharide or a chitosan polysaccharide. A method prepares this composition and it is used, in medical, pharmaceutical, agricultural, nutraceutical, food, feed, textile, cosmetic, industrial and/or environmental applications.Type: GrantFiled: November 28, 2007Date of Patent: December 23, 2014Assignee: Universite de NamurInventors: Pierre Van Cutsem, Juan Carlos Cabrera Pino
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Patent number: 8916542Abstract: Described herein are methods and compositions using chitosan derivatives to treat and/or inhibit acquisition of multiple drug resistance (MDR). Also described herein are methods and compositions using chitosan derivatives in combination with an antibacterial agent to treat a bacterial infection and/or inhibit growth of bacteria, for example, resulting in a synergistic or sensitizing effect.Type: GrantFiled: November 12, 2009Date of Patent: December 23, 2014Assignee: Synedgen, Inc.Inventors: Shenda Baker, William P. Wiesmann, Stacy Townsend
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Publication number: 20140364391Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.Type: ApplicationFiled: June 6, 2014Publication date: December 11, 2014Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA, NORTHWESTERN UNIVERSITYInventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika
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Patent number: 8906881Abstract: Chitosan-based nail formulations are useful to treat nail inflammatory diseases like psoriasis, atopic dermatitis and lichen planus. The chitosan is normally in the form of an amino-polysaccharide derivative, preferably water soluble, such as hydroxypropyl chitosan. The formulation may be a nail lacquer, a spray, a cream, an ointment, a gel, a lotion or a foam and may have a content in chitosan, chitosan derivative or a salt thereof from 0.1 to 25 wt. % with respect to the total weight of the formulation.Type: GrantFiled: February 7, 2008Date of Patent: December 9, 2014Assignee: Polichem SAInventor: Federico Mailland
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Publication number: 20140349961Abstract: The present invention related to a composition comprising an aqueous soluble-chitosan and a pharmaceutically acceptable carrier. Said composition can be used to increase the defecation rate of an individual. Together with the well known biocompatibility of chitosan, the present invention proves that the aqueous soluble-chitosan may be a potential candidate for enhancing intestinal metabolism.Type: ApplicationFiled: May 23, 2014Publication date: November 27, 2014Applicant: TAIWAN HOPAX CHEMS. MFG. CO, LTD.Inventors: Han-Fen HUANG, Li-Jane HER
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Publication number: 20140349960Abstract: The present invention related to a composition comprising an aqueous soluble-chitosan and a pharmaceutically acceptable carrier. Said composition can be used to increase lipase activity while having no harm in animal physiology. Together with the well known biocompatibility of chitosan, the present invention proves that the aqueous soluble-chitosan may be a potential candidate for body weight control.Type: ApplicationFiled: May 23, 2014Publication date: November 27, 2014Applicant: TAIWAN HOPAX CHEMS. MFG. CO, LTD.Inventors: Han-Fen HUANG, Li-Jane HER
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Publication number: 20140348954Abstract: A nutraceutical preparation and/or food supplement and/or medical device product for the use in the treatment of gastric reflux including the association of glucomannan and an organic base, chitosan, and optionally one or more carbonates.Type: ApplicationFiled: August 8, 2014Publication date: November 27, 2014Applicant: DICOFARM S.P.A.Inventors: Laura MARTELLI, Mario MARTELLI, Maurizio ACRI, Piero FERRACCHIATI
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Publication number: 20140348810Abstract: An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.Type: ApplicationFiled: August 8, 2014Publication date: November 27, 2014Applicant: POLY-MED, INC.Inventor: Shalaby W. Shalaby
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Patent number: 8889158Abstract: A method of producing a hydrogel for intra-articular supplement comprising the steps of: providing a solution of alginate, providing a solution with chitosan having a Mw between lower than 60 kD, mixing the solution of alginate and the solution of chitosan, wherein the mixed solution comprises between 0.5 and 0.7% (w/v) of chitosan and between 1 and 1.4% alginate (w/v), introducing droplets of the mixed solution into a solution with Ca2+ or Sr2+ cations and isolating polymerized beads from the solution with cations.Type: GrantFiled: February 11, 2011Date of Patent: November 18, 2014Assignees: Universite De Liege, Kitozyme S.A.Inventors: Yves Henrotin, Christelle Sanchez, Frederic Oprenyeszk, Pierre Drion
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Patent number: 8889655Abstract: A product that includes a bioadhesive treatment solution for prevention of infectious diseases in the urinary tract of a female is provided. The product includes a polysaccharide. The product is positioned over the urinary tract of a female to act as a barrier against infectious transfer. A method for applying the product and a method for making the product are also disclosed.Type: GrantFiled: July 22, 2013Date of Patent: November 18, 2014Assignee: Aegis Women's Health TechnologiesInventors: Allison London Brown, David Brown Robinson, Shantanu Gaur, Samuel Gideon Levy, Samuel Mack Hudson
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Patent number: 8883733Abstract: The present invention relates to a method of producing a hydrogel matrix comprising cartilage-forming cells wherein alginate, chitosan and cartilage-forming cells are mixed and subsequently polymerized into beads.Type: GrantFiled: February 11, 2011Date of Patent: November 11, 2014Assignee: Universite De LiegeInventors: Yves Henrotin, Frédéric Kesteloot, Christelle Sanchez
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Patent number: 8883997Abstract: Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.Type: GrantFiled: August 3, 2012Date of Patent: November 11, 2014Assignee: Isis Pharmaceuticals, Inc.Inventors: Sanjay Bhanot, Kenneth W. Dobie, Xing-Xian Yu, Brett P. Monia
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Patent number: 8877170Abstract: The present disclosure relates to implantable medical devices having a non-bioabsorbable substrate and an amphiphilic coating covalently bonded to the substrate for reducing the inflammatory response to the device after implantation.Type: GrantFiled: February 19, 2010Date of Patent: November 4, 2014Assignee: Sofradim ProductionInventors: Sebastien Ladet, Philippe Gravagna
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Publication number: 20140323433Abstract: Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.Type: ApplicationFiled: July 7, 2014Publication date: October 30, 2014Inventors: Matthew F. Myntti, Dana A. Oliver, Brian J. Vaccaro
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Publication number: 20140314738Abstract: A disinfecting composition comprises chitosan and peroxycarboxylic acid. The weight ratio of chitosan to peroxycarboxylic acid is from 0.01-100. Chitosan is selected from the group consisting of amino monosaccharide, acetylamino monosaccharide, chitooligosaccharide, chitosan polymer and the combination thereof, and peroxycarboxylic acid is a C1-C18 aliphatic peroxycarboxylic acid that is selected from the group consisting of peroxy monocarboxylic acid, peroxy dicarboxylic acid and the combination thereof.Type: ApplicationFiled: April 18, 2013Publication date: October 23, 2014Inventor: YA-CHUNG WEI
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Publication number: 20140314820Abstract: A chitosan solution is formed from chitin, which is a homopolymer of beta (1-4)-linked N-acetyl-D-glucosamine. Rinsed, dried and ground chitin undergoes a process of deacetylation to convert some N-acetyl glucosamine to glucosamine, a primary component of chitosan. The chitosan solution is prepared by mixing 5 chitosan with an alpha-hydroxy acid such as glycolic acid. An aqueous chelated silver solution is prepared by mixing silver oxide with a carboxylic acid such as citric acid. The chitosan solution can then be mixed with the silver solution resulting in a cationic complex. The cationic complex of the present invention may then be electrostatically bonded with generally negatively charged surfaces. In use, citrate promotes uptake of the silver by microbes. The antimicrobial complex can be applied via several methods of application, including an impregnated wipe, a foam, a gel, a spray, a lotion and an ointment.Type: ApplicationFiled: June 30, 2014Publication date: October 23, 2014Inventor: William Wingfield
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Publication number: 20140308236Abstract: The present invention provides a composition including an antibacterial polymer bound to a synthetic water soluble polymer, methods of using the composition for avoiding bacterial growth and processes of making plastic material which include these antibacterial compositions.Type: ApplicationFiled: January 2, 2014Publication date: October 16, 2014Inventors: Havazelet BIANCO-PELED, Maya DAVIDOVICH-PINHAS
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Patent number: 8846118Abstract: The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.Type: GrantFiled: August 21, 2008Date of Patent: September 30, 2014Assignee: Nutramax Laboratories, Inc.Inventors: Todd R. Henderson, Tarek Hammad, Medhat Soliman, Barbara E. Corson, Louis Lippiello, Robert W. Henderson
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Publication number: 20140286872Abstract: Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.Type: ApplicationFiled: March 21, 2014Publication date: September 25, 2014Applicant: University of Washington through its Center for CommercializationInventors: Miqin Zhang, Richard G. Ellenbogen, Forrest Kievit, John R. Silber, Zachary Stephen, Omid Veiseh
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Patent number: 8840867Abstract: A sclerosing embolizing hydrogel comprising from about 0.1% by weight to about 4.0% by weight of chitosan; from about 0.01M to about 1M of hydrochloric acid; from 0% by volume to about 40% by volume of iopamidol; from 0.5% by weight to about 25% by weight of ?-glycerophosphate disodium salt; and from about 0.05% by weight to about 4% by weight of sodium tetradecyl sulphate. Also a kit for synthesizing the hydrogel and a method using the hydrogel to treat a vascular defect in a subject.Type: GrantFiled: May 20, 2011Date of Patent: September 23, 2014Assignees: Val-Chum Limited Partnership, Socovar S.E.C.Inventors: Lerouge Sophie, Gilles Soulez, Ahmed Fatimi, Jean-Michel Coutu, Jean Raymond