Two Aryl Rings Or Aryl Ring Systems Bonded Directly To The Same Acyclic Carbon Patents (Class 514/648)
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Patent number: 7867523Abstract: A pharmaceutical composition for the treatment of colds and influenza. The pharmaceutical composition is a mixture of: acetaminophen, diphenhydramine, dextromethorphan, arabinogalactan, vitamin C, zinc, olive leaf extract, resveratrol and elderberry extract.Type: GrantFiled: July 18, 2008Date of Patent: January 11, 2011Inventor: Elaine A. Vanterpool
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Publication number: 20110003854Abstract: The present invention provides a new method and means for determining whether a mammalian subject having a breast cancer is likely to benefit from an endocrine treatment. The method comprise the steps of: providing a sample earlier obtained from said subject; evaluating the amount of CRABP2 protein present in at least part of said sample, and determining a sample value corresponding to said amount; comparing the obtained sample value with a reference value; and, if said sample value is higher than said reference value, concluding that the subject is likely to benefit from an endocrine treatment.Type: ApplicationFiled: December 16, 2008Publication date: January 6, 2011Inventors: Fredrik Ponten, Mathias Uhlen, Karin Jirstrom
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Publication number: 20100317740Abstract: This invention relates, e.g., to a method for predicting the response of a subject having, or at risk of developing, breast cancer to Tamoxifen therapy. The method comprises measuring the amount of phosphorylation at residues S70 of Bcl-2, Y992 of EGFR, and/or Y527 of Src in a suitable sample from the subject, wherein a statistically significantly elevated level of phosphorylation at one or more of the three residues compared to a baseline value indicates that the subject is likely to be responsive to Tamoxifen therapy.Type: ApplicationFiled: July 28, 2008Publication date: December 16, 2010Inventors: Emanuel F. Petricoin, Lance A. Liotta, Julia D. Wulfkuhle
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Publication number: 20100311665Abstract: Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans.Type: ApplicationFiled: August 2, 2010Publication date: December 9, 2010Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventor: Anil Gulati
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Patent number: 7842729Abstract: Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.Type: GrantFiled: June 3, 2005Date of Patent: November 30, 2010Assignees: The United States of America as represented by the Department of Health and Human Services, Sequella, Inc.Inventors: Marina Nikolaevna Protopopova, Richard Edward Lee, Richard Allan Slayden, Clifton E. Barry, III, Elena Bogatcheva, Leo Einck
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Publication number: 20100297225Abstract: The present invention relates to improved sustained release dosage forms such as tablets and capsules, and in particular to a pharmaceutical formulation for oral administration comprising a therapeutically effective quantity of an antimuscarinic agent, such as Tolterodine or pharmaceutical acceptable salt, derivative, prodrug and metabolite thereof in combination with a wetting agent, such as Sodium Docusate to improve the release of the active ingredient and a method for the preparation thereof.Type: ApplicationFiled: December 20, 2007Publication date: November 25, 2010Applicant: PHARMATHEN S.A.Inventors: Evangelos Karavas, Efthimios Koutris, Ioanna Koutri, Vicky Samara, Dimitrios Bikiaris
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Patent number: 7834062Abstract: The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to compositions containing such compounds and a process for making the compounds. This and other aspects of the invention are realized upon review of the entire specification.Type: GrantFiled: August 13, 2009Date of Patent: November 16, 2010Assignee: Merck Sharp & Dohme Corp.Inventors: Conrad P. Dorn, Mary Ann Powles, Thomas F. Walsh, Matthew J. Wyvratt
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Publication number: 20100278933Abstract: The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating disorders, especially cancer.Type: ApplicationFiled: June 5, 2008Publication date: November 4, 2010Applicant: University of Florida Research Foundation, IncInventors: Peter P. Sayeski, György M. Keserü
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Publication number: 20100264055Abstract: A vehicle to carry a powered medication that addresses the limitations of the prior art. It includes a system and method. A powder delivery system includes a first panel and a second panel coupled together around a periphery of the panels to form a sealed void therebetween, each the panel having a width and length about equal to a standard credit card width and length, respectively; and a powder, disposed in the void, having a quantity at least about equal to an active dose of the powder; wherein a thickness of the panels with the powder disposed therebetween is not greater than about 0.1 inches and more preferably not greater than about 0.03 inches.Type: ApplicationFiled: April 20, 2009Publication date: October 21, 2010Inventor: Jordan Eisenberg
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Publication number: 20100256175Abstract: The invention discloses a method of treatment for drug addiction, comprising administering a therapeutic agent to a patient. The therapeutic agent is delivered in an inactive state and is converted into its active form in the presence of a narcotic. The conversion produces at least one unpleasant side effect for the patient. The therapeutic agent is implanted in the form of a depot, and maybe a prodrug or microspheres. The agent may be injectable or may be packaged in the form of bioerodible sticks. The agent may also be delivered via a surgical method. The disclosed method can also be used to detect the consumption of a banned substance.Type: ApplicationFiled: April 5, 2010Publication date: October 7, 2010Inventor: D. Bommi Bommannan
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Publication number: 20100239523Abstract: The invention provides Toll-like receptor (TLR) modulators, compositions comprising the same, and methods for using the same.Type: ApplicationFiled: October 30, 2008Publication date: September 23, 2010Applicant: The Regents of the University of ColoradoInventors: Linda May Rothblum Watkins, Mark Rowland Hutchinson
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Publication number: 20100234473Abstract: A new process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N,alkyl-3-phenylpropylamines from cinnamyl chloride via N-alky-3-phenylprop-2-en-1-amine has been developed.Type: ApplicationFiled: June 18, 2007Publication date: September 16, 2010Applicant: LEK Pharmaceuticals d.d.Inventor: Erik Fischer
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Publication number: 20100233257Abstract: The present invention relates to a sublingual tablet and to the method for the preparation thereof.Type: ApplicationFiled: June 8, 2007Publication date: September 16, 2010Applicant: EthypharmInventors: Catherine Herry, Pascal Oury
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Publication number: 20100222406Abstract: The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor has a structure represented by Formula (I): Formula (I), wherein R1 is selected from the group consisting of C1-C4 alkyl, hydroxy and C1-C4 alkoxy; X is selected from the group consisting of N and CH; Z is selected from the group consisting of NH, O, S and CH2; R2 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy; and R3 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy.Type: ApplicationFiled: January 14, 2010Publication date: September 2, 2010Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Lloyd S. Gray, Doris M. Haverstick
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Publication number: 20100222298Abstract: The invention relates to novel spill resistant formulations comprising either a weak base or a weak acid as the pharmaceutical ingredient, a liquid base, a clay and a water soluble cellulose ether. The clay and cellulose ether allow for a broader pH range into which the pharmaceutically active agent may be dispersed or dissolved, and therefore allows for easier preparation and formulation of the pharmaceutical composition.Type: ApplicationFiled: May 13, 2010Publication date: September 2, 2010Applicant: Taro Pharmaceuticals U.S.A., Inc.Inventors: Satish ASOTRA, Xiaoli WANG, Zoltan BODOR
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Publication number: 20100209421Abstract: The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the certain embodiments, the method of inhibiting expression of PAX2 is to administrate the subject a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 or by increasing expression of DEFB1 is also provided.Type: ApplicationFiled: February 18, 2010Publication date: August 19, 2010Applicant: PHIGENIX, INC.Inventor: Carlton D. DONALD
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Publication number: 20100209541Abstract: Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, active compound, and optional flavoring agent; formulation II: aqueous polar solvent, active compound, optionally flavoring agent, and propellant; formulation III: non-polar solvent, active compound, and optional flavoring agent; and formulation IV: non-polar solvent, active compound, optional flavoring agent, and propellant.Type: ApplicationFiled: January 22, 2010Publication date: August 19, 2010Inventor: Harry A. DUGGER, III
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Publication number: 20100210612Abstract: The present invention relates to an in-vitro method of identifying a tumor resulting from a proliferative disease of the endometrium or ovary as responsive to anti-estrogen treatment. Further, the invention relates to an in-vitro method of identifying a candidate patient with a proliferative disease of the endometrium or ovary as suitable for anti-estrogen treatment. In a further aspect, the invention provides an in-vitro method of identifying an individual with a non-cancerous proliferative disease of the endometrium or ovary who is at risk of developing endometrial or ovarian cancer. The invention also provides kits for performing the above methods.Type: ApplicationFiled: February 15, 2008Publication date: August 19, 2010Applicant: UNIVERSITATSKLINIKUM HAMBURG-EPPENDORFInventors: Ronald Simon, Guido Sauter, Luigi Terracciano, Frederik Holst, Annette Lebeau, Andreas Turzynski
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Publication number: 20100196434Abstract: Implantable catheters are provided which comprise an antimicrobial agent incorporated in a coating or bulk distributed, in combination with a fibrinolytic agent incorporated in a top coating.Type: ApplicationFiled: May 21, 2008Publication date: August 5, 2010Applicant: ARROW INTERNATIONAL, INC.Inventors: Nisha Gupta, Joel Rosenblatt, Daniel J. Spangler
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Publication number: 20100196454Abstract: Provided herein is a scar dressing formulation comprising a blend of a high molecular weight silicone elastomer crosspolymer and a silicone oil, wherein said silicone elastomer crosspolymer is in a volatile fluid. The formulation has a soft, silky feel without being greasy and dries quickly to form a durable, flexible scar dressing.Type: ApplicationFiled: September 8, 2009Publication date: August 5, 2010Inventor: Brian KELLER
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Publication number: 20100197800Abstract: The invention relates to the treatment and/or prevention of age-related hearing loss (presbycusis) with a modulator of a metabotropic glutamate receptor 7 (mGluR7).Type: ApplicationFiled: April 23, 2008Publication date: August 5, 2010Inventors: Richard Friedman, Dietrich Stephan, Guido (Guy) Van Camp, Matthew J. Huentelman, Lut Van Laer
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Publication number: 20100190705Abstract: Provided herein are methods of decreasing glial fibrillary acidic protein (GFAP) levels in a cell. Such methods include administering an effective amount of a GFAP lowering compound to the cell. Also provided are compounds useful for the treatment of Alexander disease in subjects at risk of or diagnosed with Alexander disease and methods for the identification of such compounds.Type: ApplicationFiled: October 26, 2009Publication date: July 29, 2010Inventors: Albee Messing, Woosung Cho, Jon Scott Thorson, Randal D. Goff
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Publication number: 20100184650Abstract: Patients are subject to a post-seizure treatment regime to separately inhibitor consecutive targets of an epileptogenic cascade comprising neurotransmitter receptor signaling, kinase/phosphatase activity, protein translation, and apoptosis or inflammation.Type: ApplicationFiled: January 17, 2010Publication date: July 22, 2010Inventors: Frances E. Jensen, Sanjay N. Rakhade
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Publication number: 20100172959Abstract: A dermal or transdermal therapeutic system comprising a reservoir that contains at least one active substance, an active substance-permeable membrane which delimits the active-substance reservoir, and a closing layer. The closing layer is impermeable to the active substance at a temperature lying below the skin temperature while being permeable at skin temperature and above.Type: ApplicationFiled: December 31, 2009Publication date: July 8, 2010Applicant: ACINO AGInventors: Heike HAUSNER, Sebastian BRAUN, Heiko SPILGIES
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Publication number: 20100172974Abstract: Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques are disclosed.Type: ApplicationFiled: March 12, 2010Publication date: July 8, 2010Inventors: Benjamin Oshlack, Mark Chasin, Hua-Pin Huang
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Publication number: 20100168078Abstract: The present invention relates uses of an S1P receptor modulator such as 2-substituted 2-amino-propane-1,3-diol or 2-amino-propanol derivatives, e.g. a compound comprising a group of formula X for the treatment or prevention of neo-angiogenesis associated with a demyelinating disease, e.g. multiple sclerosis.Type: ApplicationFiled: June 25, 2007Publication date: July 1, 2010Inventors: Peter C. Hiestand, Christian Schnell
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Publication number: 20100158956Abstract: Compositions and methods for combination therapy are provided. The compositions comprise a multiple unit dosage form having both a therapeutic agent and a nutritional supplement. The combination therapy is useful for restoring a nutrient depletion associated with a particular disease state. Additionally, the combination therapy can prevent or attenuate the depletion of a nutrient caused, in whole or in part, by the co-administrated therapeutic drug. Methods of manufacturing the formulations are likewise described.Type: ApplicationFiled: December 22, 2009Publication date: June 24, 2010Inventor: James R. Komorowski
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Publication number: 20100160275Abstract: The present invention relates to methods and compositions for cancer prevention and treatment. In particular, the present invention provides methods and compositions for modulating, studying, preventing and treating progesterone receptor related carcinogenesis with anti-progesterones and anti-estrogens.Type: ApplicationFiled: September 26, 2007Publication date: June 24, 2010Inventor: Eva Y.H.P. Lee
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Publication number: 20100158914Abstract: The invention concerns uses of anti-KL? agents, and detection of KL? and/or FGF19 and/or FGFR4.Type: ApplicationFiled: April 1, 2008Publication date: June 24, 2010Inventor: Luc Desnoyers
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Publication number: 20100159021Abstract: Provided herein are compositions and methods for treating cancer by increasing the pro-apototic actions of small molecule ligands of integrin RGD recognition sites such as polyphenols by administering such compounds in conjunction with anti-angiogenic thyroid hormone analogs such as tetrac or triac.Type: ApplicationFiled: December 22, 2009Publication date: June 24, 2010Inventors: Paul Davis, Faith B. Davis, Shaker A. Mousa, Hung-Yun Lin
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Publication number: 20100152201Abstract: The invention provides antihistamine drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the antihistamine drug not attached to the water-soluble oligomer.Type: ApplicationFiled: March 12, 2008Publication date: June 17, 2010Applicant: Nektar TherapeuticsInventors: Jennifer Riggs-Sauthier, Wen Zhang, Tacey X Viegas, Michael D Bentley
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Publication number: 20100152173Abstract: The present invention relates to a tablet comprising at least a first and second active, the first active being in the form of a non-aqueous granulate, the second active ingredient being in the form of melt extrudated granules or a granulate (aqueous or non-aqueous). The first and second active forms are blended together. The present invention is further directed to a method of producing said tablet.Type: ApplicationFiled: March 19, 2008Publication date: June 17, 2010Inventors: Huw Jones, Gurmeet Rajput
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Publication number: 20100151035Abstract: The present invention relates to a stable pharmaceutical composition of a poorly water-soluble drug with a view to increasing its solubility and bioavailability. The present invention relates to a solid dispersion of a poorly water-soluble drug.Type: ApplicationFiled: March 10, 2008Publication date: June 17, 2010Applicant: Sandoz AGInventors: Bharatrajan Ramaswami, Manisha Rajesh Patil, Aditi Das
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Publication number: 20100143449Abstract: The present invention relates to pharmaceutical formulations comprising at least two compounds, one effecting opioid analgesia and one effecting cyclooxygenase 1 and 2 activity, in amounts sufficient to potentiate an antinociceptive response when both compounds are topically administered in a physiologically acceptable topical excipient. The pharmaceutical formulations of the present invention are used to prevent or relieve acute pain and chronic peripheral neuropathy and/or neuropathic inflammation in a patient in need of such treatment.Type: ApplicationFiled: February 29, 2008Publication date: June 10, 2010Inventor: Yuri Kolesnikov
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Publication number: 20100130617Abstract: The present invention relates to new ethanolamine modulators of NMDA receptors and/or muscarinic acetylcholine receptors, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: November 23, 2009Publication date: May 27, 2010Applicant: AUSPEX PHARMACEUTICALS, INC.Inventors: Thomas G. Gant, Sepehr Sarshar
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Publication number: 20100129471Abstract: The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.Type: ApplicationFiled: April 4, 2008Publication date: May 27, 2010Inventors: Mouâd Alami, Jean-Daniel Brion, Olivier Provot, Jean-François Peyrat, Samir Messaoudi, Abdallah Hamze, Anne Giraud, Jérôme Bignon, Joanna Bakala, Jian-Miao Liu
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Publication number: 20100119482Abstract: Methods are provided for treating a subject for a condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated during at least one predetermined phase of the subject's menstrual cycle to alter the parasympathetic activity/sympathetic activity ratio in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, including various disease conditions, that increase in severity and/or occurrence during one or more phases of the menstrual cycle. Also provided are systems and kits for use in practicing the subject methods.Type: ApplicationFiled: December 24, 2009Publication date: May 13, 2010Inventors: Anthony Joonkyoo Yun, Partic Yuarn-Bor Lee
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Publication number: 20100112041Abstract: The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E-guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.Type: ApplicationFiled: November 21, 2007Publication date: May 6, 2010Applicant: JINA PHARMACEUTICALS, INC.Inventors: Ateeq Ahmad, Shoukath M. Ali, Moghis U. Ahmad, Saifuddin Sheikh, Imran Ahmad
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Publication number: 20100105672Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.Type: ApplicationFiled: August 3, 2009Publication date: April 29, 2010Inventors: Philip A. Swain, Victoria C. Schad, Julia L. Greenstein, Mark A. Exley, Barbara S. Fox, Stephen P. Powers
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Publication number: 20100099642Abstract: The invention relates to the use of TGF-beta stimulating agents, and in particular members of the triphenylethylene class of pharmaceutical agents, for the prevention, prophylaxis, treatment or amelioration of symptoms of cardiovascular disease, autoimmune diseases or neurodegeneration. In particular, improved compositions consisting of triphenylethylene agents combined with one or more additional active pharmaceutical agents in order to mitigate against side-effects of the triphenylethylene are described and claimed.Type: ApplicationFiled: February 7, 2008Publication date: April 22, 2010Applicant: TCP Innovations LimitedInventor: David J. Grainger
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Publication number: 20100098690Abstract: The present invention provides a pharmaceutical composition comprising a combination of an Hsp 90 family protein inhibitor and at least one compound, the said pharmaceutical composition wherein the Hsp 90 family protein inhibitor is a benozoyl compound represented by formula (I): [wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkyl, CONR7R8 (wherein R7 and R8, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like), or the like; R2 represents substituted or unsubstituted aryl, or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like], or a prodrug thereof; or a pharmaceutically acceptable salt thereof, and the like.Type: ApplicationFiled: March 5, 2008Publication date: April 22, 2010Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Shiro Soga, Toshihiko Ishii, Takayuki Nakashima, Yukimasa Shiotsu, Shiro Akinaga
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Publication number: 20100093672Abstract: Use of an S1P receptor modulator in the treatment or prevention of a disease or condition dependent on brain-derived neurotrophic factor (BDNF) expression.Type: ApplicationFiled: May 1, 2008Publication date: April 15, 2010Inventors: Yves-Alain Barde, Graeme Bilbe, Ruben Deogracias, Rainer R. Kuhn, Tomoya Matsumoto, Anis K. Mir, Anna S. Schubart
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Publication number: 20100080847Abstract: This invention relates to a medicinal composition, which rapidly disintegrates when taken in the oral cavity and shows sufficient hardness upon production, distribution and use in usual manner, can be obtained by adding, to a sugar alcohol and/or saccharide, a sugar alcohol and/or saccharide having a lower melting point than the first-mentioned sugar alcohol and/or saccharide and then subjecting the resulting powder to combined processing of compression and heating. This invention can provide medicinal compositions, which rapidly disintegrate when taken in the oral cavity without water and are excellent in handling ease owing to exhibition of sufficient hardness upon their production, transportation and use in usual manner, and can also provide a process for the production of the medicinal compositions, which is simpler and can avoid contact between an active ingredient and water as needed.Type: ApplicationFiled: December 4, 2009Publication date: April 1, 2010Applicant: DAIICHI PHARMACEUTICAL CO., LTD.Inventors: Hiroaki Nakagami, Yoshio Kuno
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Publication number: 20100074927Abstract: Microparticle carriers, particularly protein-encapsulated microbubbles, are used to deliver antiproliferative drugs to target sites in a subject. In particular, antirestenotic drugs are delivered to areas of vascular injury for treatment or prevention of hyperproliferative disease, e.g. stenosis, in blood vessels; and antineoplastic drugs are targeted to tumor sites.Type: ApplicationFiled: September 17, 2009Publication date: March 25, 2010Inventors: Patrick L. Iversen, Nicholas Kipshidze
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Publication number: 20100069340Abstract: This invention is directed to a pharmaceutical composition comprising an Src kinase inhibitor and an aromatase inhibitor, and to the use of a combination of an Src kinase inhibitor and an aromatase inhibitor in treating abnormal cell proliferation and abnormal angiogenesis associated with cancer, including breast cancer.Type: ApplicationFiled: September 11, 2009Publication date: March 18, 2010Applicant: WyethInventors: Charles Michael Zacharchuk, Frank Charles Boschelli, Jennifer Michele Golas, Kim Timothy Arndt
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Patent number: 7678821Abstract: Disclosed herein are pharmaceutical compositions comprising combinations of tolterodine, an antimuscarinic agent, and pilocarpine, a compound that causes stimulation of salivary glands. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient said pharmaceutical composition.Type: GrantFiled: August 28, 2006Date of Patent: March 16, 2010Assignee: TheraVida, Inc.Inventor: Mehdi Paborji
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Publication number: 20100063010Abstract: A method for administering a spill-resistant pharmaceutical formulation comprises delivery from a squeezable container of a pharmaceutical agent in a suitable vehicle comprising a liquid base and a thickening agent.Type: ApplicationFiled: October 22, 2009Publication date: March 11, 2010Applicant: Taro Pharmaceutical Industries Ltd.Inventors: Rakesh MEHTA, Dan Moros
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Publication number: 20100063075Abstract: A compound of formula (1): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.Type: ApplicationFiled: October 15, 2009Publication date: March 11, 2010Inventors: Eva Altmann, Rene Beerli, Marc Gerspacher, Johanne Renaud, Sven Weiler, Leo Widler
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Patent number: 7674935Abstract: Methods for preparing crystalline forms of O-desmethylvenlafaxine are described.Type: GrantFiled: April 17, 2007Date of Patent: March 9, 2010Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Sigalit Levi, Valerie Niddam-Hildesheim, Iamas Koltai
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Publication number: 20100029624Abstract: A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.Type: ApplicationFiled: July 16, 2009Publication date: February 4, 2010Applicant: King's College LondonInventors: Nnaemeka Ikechukwu AMOBI, Ian Christopher SMITH