Sustained Or Differential Release Type Patents (Class 514/964)
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Patent number: 4855132Abstract: Biodegradible polymers are provided which may contain a biologically active substance, e.g. a drug such as insulin, which is released over a period of time as the polymer erodes when in contact with a body fluid. The polymer contains an amine functionality whereby it erodes faster at low acid pH's than at higher acid pH's. As an example, the polymer may contain insulin and may contain or may have an encapsulating hydrogel containing glucose oxidase. As the blood sugar level of a diabetic person rises, e.g., after a meal, glucose diffuses into the polymer or hydrogel and is converted to gluconic acid which lowers the pH, and accelerates erosion and the release of insulin.Type: GrantFiled: July 1, 1988Date of Patent: August 8, 1989Assignee: S R I InternationalInventors: Jorge Heller, Donald W. H. Penhale, Steve Y. Ng
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Patent number: 4855313Abstract: The invention is a method of stimulating cashmere growth on cashmere-producing goats. The method includes administering melatonin by a sustained release delivery system.Type: GrantFiled: November 15, 1988Date of Patent: August 8, 1989Inventors: Robert A. S. Welch, Keith Betteridge
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Patent number: 4851225Abstract: A dispenser for use, for instance, as a rumen bolus is a generally cylindrical container (1) for material to be dispersed into the digestive tracts, etc. of a ruminant. The container has a closure (3) held in place by a controlled release glass (CRG) member (5). When this member is dissolved, the closure (3) comes out and the contents are released. The cylindrical container can be formed by a hole in a larger member which has several such holes so that different materials can be released, or materials released at different times.Variants include stacked arrangements in which several dispenser compartments are coupled so that as one is emptied a CRG member is dissolved to release material in the next compartment.In some cases the CRG member acts both as the release device, and as the closure for its compartment, and in others it also acts as a means of linking a number of detachable sections.Type: GrantFiled: April 6, 1987Date of Patent: July 25, 1989Assignee: STC PLCInventors: Cyril F. Drake, Alfred J. Arch
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Patent number: 4847077Abstract: Controlled release pharmaceutical preparations containing coated sulfonic acid cationic exchange resin drug complex particles, the resin particles having been treated, prior to coating, with about 15 to 25% by weight of glycerin, based on the combined weight of the glycerin and the drug resin complex particles.Type: GrantFiled: January 27, 1987Date of Patent: July 11, 1989Assignee: Pennwalt CorporationInventor: Yegnaswami Raghunathan
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Patent number: 4847257Abstract: 5-Amino or substituted amino 1,2,3-triazoles are disclosed as a new class of antiproliferative agents useful in the treating and managing of psoriasis, inflammatory bowel syndrome, cutaneous leishmanilisis and certain types of cancer.Type: GrantFiled: August 20, 1987Date of Patent: July 11, 1989Assignee: Merck & Co., Inc.Inventors: Donald Hupe, Lawrence Argenbright, Nancy Behrens, Barbara A. Azzolina
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Patent number: 4845042Abstract: The invention provides an immunizing agent or preparation e.g. a vaccine for parenteral administration comprising particles of coalesced and covalently interlinked physiologically compatible proteinaceous molecules and, entrapped in these particles, an immunogen adapted to be released by the gradual proteolysis of the particles and, when so released, being of sufficient size to elicit an immuno response to characteristic immunogenic determinants of the immunogen. The proteinaceous molecules are preferably homotypic for the animal to be immunized. Preferably, the particles or molecules carrying the immunogenic determinants are crosslinked to the proteinaceous molecules.Type: GrantFiled: April 4, 1985Date of Patent: July 4, 1989Assignee: South African Inventions Development CorporationInventors: John F. E. Newman, Donald A. Hendry
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Patent number: 4832994Abstract: Anti-smoking oral preparations are provided containing a silver compound as the anti-smoking agent and a sweetener in which the silver compound is present in amounts of from 0.1 mg. to 2.5 mg. and the ratio of sweetness intensity based on sucrose to silver compound content is from 100:1 to 2500:1.Type: GrantFiled: September 2, 1987Date of Patent: May 23, 1989Inventor: Michael S. Fey
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Patent number: 4808399Abstract: The present invention pertains to a preparation for diagnosing the transport function of the fallopian tube and to a method for making such a preparation.The diagnostic preparation for investigation of the transport function of female fallopian tube, comprises a suspension of a biocompatible, biodegradable, and, if desired, labelled particles, in a vehicle commonly used for parenteral applications wherein the particles have a spherical shape with diameters in the region 10 to 600 um, which are formed from a soft hydrophilic gel based on a polymer selected from the group comprising additionally crosslinked water-soluble nontoxic and biodegradable inert polysaccharides and physiologically inert water-soluble and biodegradable poly(amino acids), polypeptides, and their derivatives, which may contain physiologically active substances.Type: GrantFiled: December 11, 1986Date of Patent: February 28, 1989Assignee: Ceskoslovenska akademie vedInventors: Frantisek Rypacek, Jan Uher, Jaroslav Drobnik
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Patent number: 4806355Abstract: Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-permeable hydrogel membrane which permits the passage of materials and oxygen to the cells and metabolic products from the cells while retaining the cells encapsulated. The biocompatible semi-permeable membrane has an outer negatively-charged surface, which imparts to the microcapsules the ability to maintain long term effectiveness.Type: GrantFiled: June 8, 1987Date of Patent: February 21, 1989Assignee: Connaught Laboratories LimitedInventors: Mattheus F. A. Goosen, Geraldine M. O'Shea, Anthony M. F. Sun
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Patent number: 4795436Abstract: A controlled release treatment composition and method of use are disclosed. The composition includes a bioadhesive and an effective amount of a treating agent. The bioadhesive is a water-swellable, but water-insoluble, fibrous, cross-linked carboxy-functional polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkenyl polyether.Type: GrantFiled: September 22, 1986Date of Patent: January 3, 1989Assignee: Bio-Mimetics, Inc.Inventor: Joseph R. Robinson
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Patent number: 4794000Abstract: The present invention provides for an oral drug delivery system based on a two phase liquid coacervate system prepared from water and one or more surfactants selected from anionic, cationic, amphoteric, and non-toxic surfactants, polysaccharides, synthetic polymers and polysorbates and their derivatives, and in which a pharmaceutical component is incorporated. The delivery system may be prepared in the form of a microemulsion as well as other forms including encapuslated microparticles. The claimed oral composition is useful to delivery oral dosage forms of drugs, their salts and derivatives thereof; biologicals, enzymes, and other pharmocologically active compositions. A method to prepare the oral drug delivery system is also disclosed.Type: GrantFiled: January 8, 1987Date of Patent: December 27, 1988Assignee: Synthetic Blood CorporationInventor: Bernard Ecanow
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Patent number: 4786501Abstract: This invention relates to a method for purifying and concentrating biologically active growth hormone to produce growth hormone in a form suitable for incorporation into a controlled release device (or system). A buffered solution of purified recombinant growth hormone is dialyzed against a buffered solution until the salt level is reduced to less than 5% and then lyophilized.Type: GrantFiled: July 15, 1985Date of Patent: November 22, 1988Assignee: International Minerals & Chemical Corp.Inventors: Alvin M. Janski, Ren-Der Yang
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Patent number: 4786509Abstract: A sustained release theophylline containing oral dosage formulation comprising theophylline containing micropellets coated with from about 0.5% to about 2% by weight of a pharmaceutically acceptable water-insoluble film former, preferably ethyl cellulose and having first order release. The formulation is an improvement over theophylline containing micropellets coated with two film formers which have zero order release. The oral dosage formulation has superior non-fasting release and absorption characteristics when compared to the zero order release formulation.Type: GrantFiled: May 18, 1987Date of Patent: November 22, 1988Assignee: Schering CorporationInventors: Richard Chang, Robert P. Giannini, Charles Hsaio
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Patent number: 4780322Abstract: The invention relates to a novel method of producing slow-release pharmaceutical forms administered per os, by simultaneously employing two resins having anionic character, the proportions of said resins being variable.By varying the ratio of the amounts of active principles on the respective two resins, it is possible to modify the release kinetics of active principle; and by independently varying the amount of carboxylic resin it is possible to produce stabile pharmaceutical preparations which are in liquid, semi-liquid, or solid form.Type: GrantFiled: January 21, 1986Date of Patent: October 25, 1988Assignee: Societe Cortial, S.A.Inventors: Rosa Martani, Elisabeth Le Huede, Jeanne Dumas
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Patent number: 4780317Abstract: A sustained release antimicrobial agent comprises a clathrate compound composed of a water-soluble microbicide and at least one of the compounds shown at (I) to (V) below:(I) 1,1'-bi-2-naphthol;(II) 1,1,4,4-tetraphenyl-2-butyn-1,4-diol;(III) 9,10-di(4-methylphenyl)-9,10-dihydroznthracene-9,10-diol;(IV) 1,1-bis(4-hydroxyphenyl)-cyclohexane; and(V) 1,1,6,6-tetra(2,4-dimethylphenyl)-2,4-hexadiyne-1,6-diol.A method which uses it for preventing the fouling of a water system is also disclosed.Type: GrantFiled: January 22, 1987Date of Patent: October 25, 1988Assignee: Kurita Water Industries Ltd.Inventors: Ayako Sekikawa, Hideo Sugi, Kenji Tahara, Fumio Toda
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Patent number: 4775659Abstract: This invention provides injectable semi-solid formulations comprising a pharmaceutically or veterinary active agent, an oil and a suitable glyceride release modifying agent.Type: GrantFiled: August 19, 1985Date of Patent: October 4, 1988Assignee: Eli Lilly and CompanyInventors: Arvind L. Thakkar, Roger G. Harrison
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Patent number: 4774329Abstract: A complex of cyclodextrin and cetylpyridinium chloride is disclosed as a controlled release agent of cetylpyridinium chloride. The cyclodextrin can be either cyclodextrin molecule, a polymer of cyclodextrin or modified cyclodextrin. The method of forming the complex is also disclosed.Type: GrantFiled: August 4, 1987Date of Patent: September 27, 1988Assignee: American Maize-Products CompanyInventor: Robert B. Friedman
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Patent number: 4765980Abstract: Porcine serum albumin stabilizes porcine growth hormone, and provided for sustained release of porcine growth hormone in implant devices for swine.Type: GrantFiled: April 28, 1986Date of Patent: August 23, 1988Assignee: International Minerals & Chemical Corp.Inventors: Randolph B. DePrince, Ravi Viswanathan
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Patent number: 4764364Abstract: Biodegradible polymers are provided which may contain a biologically active substance, e.g. a drug such as insulin, which is released over a period of time as the polymer erodes when in contact with a body fluid. The polymer contains an amine functionality whereby it erodes faster at low acid pH's than at higher acid pH's. As an example, the polymer may contain insulin and may contain or may have an encapsulating hydrogel containing glucose oxidase. As the blood sugar level of a diabetic person rises, e.g., afte a meal, glucose diffuses into the polymer or hydrogel and is converted to gluconic acid which lowers the pH, and accelerates erosion and the release of insulin.Type: GrantFiled: February 25, 1986Date of Patent: August 16, 1988Assignee: S R I InternationalInventors: Jorge Heller, Donald W. H. Penhale, Steve Y. Ng
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Patent number: 4759923Abstract: It has been found that certain derivatives of poly(diallylmethylamine) are therapeutically effective serum cholesterol lowering agents.Type: GrantFiled: June 25, 1987Date of Patent: July 26, 1988Assignee: Hercules IncorporatedInventors: George A. Buntin, Bernard J. Scheve
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Patent number: 4742054Abstract: A method, and compositions, for treating an animal with an injured spinal cord, causing loss to sensory function and motor control, to regain such function and control. The method comprises the administration of at least 1 .alpha..sub.2 -adrenergic receptor agonist or a serotonergic receptor agonist or a dopaminergic receptor agonist, and preferably a combination with an anti-desensitization agent, such as a xanthine, a .beta.-adrenergic receptor agonist or a vascular skeletal muscle dilator. The composition comprises at least 1 receptor agonist and a second compound acting in conjunction therewith or preventing desensitization thereof.Type: GrantFiled: January 16, 1985Date of Patent: May 3, 1988Inventor: Nosrat E. Naftchi
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Patent number: 4717713Abstract: A controlled release pharmaceutical composition including a solution or suspension vehicle and a pharmaceutically active agent. The composition is administered to the body in a normally liquid formulation and thereafter forms a semi-solid gel-like matrix in the environment of the stomach thereby effecting controlled release of the pharmaceutically active agent.Type: GrantFiled: October 31, 1983Date of Patent: January 5, 1988Assignee: Research CorporationInventors: Joel L. Zatz, David W. Woodford
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Patent number: 4707362Abstract: A vehicle which provides rapid release of a drug and prolonged release of a drug is disclosed.Type: GrantFiled: February 15, 1985Date of Patent: November 17, 1987Assignee: Biotek, Inc.Inventor: Elie S. Nuwayser
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Patent number: 4702917Abstract: Polylactones blended with a polyether and then shaped are leached with aqueous solution of an organic solvent such as alcohol or acetone to elute selectively the polyether and form interconnected pores within the shaped polylactone. The result is a shaped article suitable for use a reservoir for the controlled release of high molecular weight drugs.Type: GrantFiled: November 18, 1985Date of Patent: October 27, 1987Assignee: Research Triangle InstituteInventor: Anton Schindler
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Patent number: 4666704Abstract: A controlled release implant composition which includes a core comprising a macromolecular drug and a water insoluble polymer and a homogeneous outer polymeric membrane formed by coating said core with an organic solution of a water insoluble polymer and a water soluble pore-forming agent.Type: GrantFiled: May 24, 1985Date of Patent: May 19, 1987Assignee: International Minerals & Chemical Corp.Inventors: Mohamad D. Shalati, Kallidaikurichi N. Sivaramakrishnan
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Patent number: 4663308Abstract: Polymers from ethylenically unsaturated monomers, cross-linked by a substituted or unsubstituted divinylazobenzene are useful as carriers or capsules for medicaments, which are degraded by the enzymes of the upper gastrointestinal tract or which must be transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine.Polymers containing monomeric units of the formulaH.sub.2 C.dbd.CH--C.sub.6 H.sub.4 --N.dbd.N--M,wherein M is the residue of an amino-containing medicament, are useful as carriers for therapeutic agents or as therapeutic agents per se.Type: GrantFiled: July 18, 1984Date of Patent: May 5, 1987Assignees: Medical College of Ohio, Bowling Green State UniversityInventors: Murray Saffran, Douglas C. Neckers
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Patent number: 4617186Abstract: A sustained release drug delivery system suitable for ophthalmic use is described. The delivery system utilizes a cationic polymer (polyquat) to deliver a drug residue. The drug residue delivered may comprise an anionic drug or a drug-carrier complex.Type: GrantFiled: December 28, 1984Date of Patent: October 14, 1986Assignee: Alcon Laboratories, Inc.Inventors: Doris Schafer, Rolf Schafer
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Patent number: 4615699Abstract: A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 .mu.g/cm.sup.2 hr and preferably in the range of 50-150 .mu.g/cm.sup.2 hr. Ethanol delivered at a rate of from 250-500 .mu.g/cm.sup.2 hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.Type: GrantFiled: May 3, 1985Date of Patent: October 7, 1986Assignee: ALZA CorporationInventors: Robert M. Gale, Randall G. Berggren
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Patent number: 4590063Abstract: Compounds of the formula ##STR1## where R is a methyl, ethyl or propyl group and n is 1 or 2 and their nontoxic salts are useful as anticonvulsants.Type: GrantFiled: April 25, 1985Date of Patent: May 20, 1986Assignee: Adria Laboratories, Inc.Inventors: John P. Carter, Jr., Richard L. Wolgemuth
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Patent number: 4587118Abstract: A dry sustained release oral dosage formulation of theophylline and a method of orally administering theophylline is disclosed. The oral formulation is comprised of a capsule which includes upper and lower parts which are connectible and easily separable from each other, and a plurality of micropellets present in the capsule. The micropellets provide sustained release of theophylline when taken by a patient and are comprised of inner seeds coated with a mixture of theophylline and polyvinylpyrrolidone which is further coated with a mixture of ethylcellulose and hydroxypropylcellulose. The oral dosage formulation is administered by separating the upper and lower parts of the capsule and placing the micropellets on a food which is preferably soft to the extent of not requiring chewing and then eating the food with the micropellets thereon.Type: GrantFiled: December 12, 1984Date of Patent: May 6, 1986Assignee: Key Pharmaceuticals, Inc.Inventor: Chiin H. Hsiao
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Patent number: 4568536Abstract: An absorbable biologically compatible putty-like composition is used as a matrix from which immunologically or pharmacologically active agents, such as antibiotics, can be introduced into the body to provide a slow sustained release of the agent over an extended period of time. A preferred matrix comprises a mixture of calcium stearate, dextran and castor oil.Type: GrantFiled: February 8, 1985Date of Patent: February 4, 1986Assignee: Ethicon, Inc.Inventors: Richard L. Kronenthal, Frank V. Mattei, Alan J. Levy
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Patent number: 4540566Abstract: A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a controlled and prolonged release pattern upon administration, the carrier base material being a mixture of one or more nonionic cellulose ethers and an anionic surfactant, and wherein at least one of the cellulose ethers is a modified hydroxypropylmethylcellulose having a number average molecular weight of less than 50,000 and has been modified by successive or concurrent exposure to moisture and air.Type: GrantFiled: April 2, 1984Date of Patent: September 10, 1985Assignee: Forest Laboratories, Inc.Inventors: Stanley S. Davis, Norman G. Gaylord
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Patent number: 4532244Abstract: Migraine headaches are treated or prevented by the administration of scopolamine or a pharmaceutically acceptable salt thereof. Preferably scopolamine hydrocloride is administered to the patient transdermally at a substantially constant rate using a metered drug delivery system conveniently adhered to the patient's skin.Type: GrantFiled: September 6, 1984Date of Patent: July 30, 1985Inventor: Margaret N. Innes