Benzimidazoles Patents (Class 536/28.9)
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Patent number: 11684632Abstract: The invention relates to novel compositions and methods of using maribavir which enhance its effectiveness in medical therapy, as well as to maribavir isomers and methods of use thereof for counteracting the potentially adverse effects of maribavir isomerization in vivo in the event it occurs.Type: GrantFiled: August 3, 2020Date of Patent: June 27, 2023Assignee: Takeda Pharmaceutical Company LimitedInventor: John D. Peabody, III
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Patent number: 8753641Abstract: The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of complexing a metal, which metal is preferably a radioactive metal, to the use of these molecules and to therapeutic and diagnostic compositions containing them.Type: GrantFiled: July 20, 2009Date of Patent: June 17, 2014Assignee: University of ZurichInventors: Roger Ariel Alberto, Pascal Jean-Marie Hafliger
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Publication number: 20130296542Abstract: The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(?-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.Type: ApplicationFiled: May 2, 2013Publication date: November 7, 2013Applicant: ViroPharma IncorporatedInventor: ViroPharma Incorporated
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Patent number: 8546344Abstract: The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(?-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.Type: GrantFiled: October 27, 2011Date of Patent: October 1, 2013Assignee: ViroPharma IncorporatedInventors: Gerard Coquerel, Guillaume Levilain, Marie-Noelle Petit, Servane Coste-Leconte
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Publication number: 20120277177Abstract: The invention relates to novel crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-(?-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.Type: ApplicationFiled: October 27, 2011Publication date: November 1, 2012Inventors: Eugene C. Amparo, Cristina Stoica, Mihaela Pop, Jaroslaw Mazurek
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Publication number: 20120178709Abstract: The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(?-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.Type: ApplicationFiled: October 27, 2011Publication date: July 12, 2012Inventors: Gerard Coquerel, Guillaume Levilain, Marie-Noelle Petit, Servane Coste-Leconte
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Patent number: 7858773Abstract: The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity.Type: GrantFiled: March 26, 2009Date of Patent: December 28, 2010Assignee: GlaxoSmithKline LLCInventor: Stephen Freeman
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Patent number: 7714123Abstract: The invention relates to crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-?-L-ribofuranosyl-1Hbenzimidazole, pharmaceutical compositions comprising the same, processes for preparing the same, and their use in medical therapy.Type: GrantFiled: October 25, 2007Date of Patent: May 11, 2010Assignee: GlaxoSmithKline LLCInventors: Bobby Neal Glover, Lian-Feng Huang, Robert William Lancaster, Stacey Todd Long, Michele Catherine Rizzolio, Eric Allen Schmitt, Barry Riddle Sickles
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Publication number: 20090187015Abstract: The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity.Type: ApplicationFiled: March 26, 2009Publication date: July 23, 2009Inventor: Stephen Freeman
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Publication number: 20090018101Abstract: S-Adenosyl-L-methionine analogs of formula (I) wherein R comprises a carbon-carbon double bond, carbon-oxygen double bond, carbon-sulfur double bond, carbon-nitrogen double bond, a carbon-carbon triple bond, carbon-nitrogen triple bond or an aromatic carbocyclic or heterocyclic system in ?-position to the sulfonium center, X— is an organic or inorganic anion carrying one or more negative charges, Z is —CR1R2—, —O—, —S— or —NR3— and R1, R2 and R3 are independently selected from H, D and C1-C12 alkyl. Also disclosed are complexes of the compound with a methyltransferase, pharmaceutical compositions comprising the same, methods for modifying biomolecule using the compound, and methods for detecting sequences specific methylation of biomolecules using the compound.Type: ApplicationFiled: October 11, 2007Publication date: January 15, 2009Applicants: RWTH AACHEN, INSTITUTE OF BIOTECHNOLOGYInventors: Elmar Weinhold, Christian Dalhoff, Saulius Klimasauskas, Grazvydas Lukinavicius
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Patent number: 7375235Abstract: The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity.Type: GrantFiled: July 26, 2005Date of Patent: May 20, 2008Assignee: SmithKline Beecham CorporationInventor: Stephen Freeman
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Patent number: 7297683Abstract: The invention relates to Form physical forms of 5,6-dichloro-2-(isopropylamino)-1-?-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, and their use in medical therapy.Type: GrantFiled: October 29, 2001Date of Patent: November 20, 2007Assignee: SmithKline Beecham CorporationInventors: Bobby Neal Glover, Lian-Feng Huang, Robert William Lancaster, Stacey Todd Long, Michele Catherine Rizzolio, Eric Allen Schmitt, Barry Riddle Sickles
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Patent number: 7101994Abstract: The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity.Type: GrantFiled: April 10, 2001Date of Patent: September 5, 2006Assignee: SmithKline Beecham CorporationInventor: Stephen Freeman
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Patent number: 6617315Abstract: The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of restenosis.Type: GrantFiled: November 14, 2000Date of Patent: September 9, 2003Inventors: Stanley Dawes Chamberlain, George Walter Koszalka, Jeffrey H. Tidwell, Nanine Agneta Vandraanen
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Publication number: 20030119762Abstract: The present invention relates to polysubstituted benzimidazoles, having the following formula: 1Type: ApplicationFiled: October 2, 2002Publication date: June 26, 2003Inventors: Leroy B. Townsend, John C. Drach
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Publication number: 20020177703Abstract: The invention relates to Form physical forms of 5,6-dichloro-2-(isopropylamino)-1-&bgr;-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, and their use in medical therapy.Type: ApplicationFiled: October 29, 2001Publication date: November 28, 2002Inventors: Bobby Neal Glover, Lian-Feng Huang, Robert William Lancaster, Stacey Todd Long, Michele Catherine Rizzolio, Eric Allen Schmitt, Barry Riddle Sickles
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Patent number: 6482939Abstract: The invention relates to Form VI 5,6-dichloro-2-(isopropylamino)-1-&bgr;-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, and their use in medical therapy.Type: GrantFiled: November 17, 2000Date of Patent: November 19, 2002Assignee: SmithKline Beecham CorporationInventors: Anne Hodgson, Lian-Feng Huang
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Patent number: 6469160Abstract: The invention relates to Form physical forms of 5,6-dichloro-2-(isopropylamino)-1-&bgr;-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, and their use in medical therapy.Type: GrantFiled: October 6, 2000Date of Patent: October 22, 2002Assignee: SmithKline Beecham CorporationInventors: Bobby Neal Glover, Lian-Feng Huang, Robert William Lancaster, Stacey Todd Long, Michele Catherine Rizzolio, Eric Allen Schmitt, Barry Riddle Sickles
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Patent number: 6455506Abstract: The present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds. In one embodiment, the present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds selected from the group consisting of compounds having a formula selected from the following: wherein R2, R4, R5, R6, and R7 are independently the same or different and independently selected from the group consisting of: —H, —F, —Cl, —Br, —I, —NO2, —N(R8)2, —OR8, —SR12, and —CF3, wherein R8 is independently —H or an alkyl group having 1-6 carbon atoms and wherein R12 is independently —H or a hydrocarbyl group having 1-10 carbon atoms; and, R9, R10 and R11 are independently the same or different and are H or a hydroxyl protecting group; anomeric and optical isomers thereof; and, pharmaceutically acceptable salts and prodrug derivatives thereof.Type: GrantFiled: July 29, 1998Date of Patent: September 24, 2002Assignee: SmithKline Beecham CorporationInventors: Leroy B. Townsend, John C. Drach
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Patent number: 6413938Abstract: According to a first aspect of the invention there is provided compounds of formula (I): wherein: R1 is hydroxy; O-acetyl; or a halo atom; R2 is hydroxy; O-acetyl; or a halo atom; R3 is hydrogen; a halo atom; azido; C2-6alkenyl; C2-6alkynyl; C6-14aryl C2-6alkenyl; C6-14arylC2-6alkynyl —NR8R9 (where R8 and R9 may be the same or different and are hydrogen, C1-8alkyl, cyanoC1-8alkyl, hydroxyC1-8alkyl, haloC1-8alkyl, C3-7cycloalkyl, C1-8alkylC3-7cycloalkyl, C2-6alkenyl, C3-7cycloalkylC1-8alkyl, C2-6alkynyl, C6-14aryl, C6-14arylC1-8alkyl, heterocycleC1-8alkyl, C1-8alkylcarbonyl, C6-14arylsulfonyl, C1-8alkysulfonyl, or R8R9 together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); —OR10 (where R10 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl, C2-6alkenyl, C2-6alkynyl, C6-14aryl C2-6alkenyl or C6-14arylC2-6alkynyl); or —SR11 (where R11 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl).Type: GrantFiled: August 25, 1999Date of Patent: July 2, 2002Assignees: The Regents of the University of Michigan, Glaxo Wellcome Inc.Inventors: Jeffrey H. Tidwell, Stanley D. Chamberlain, George A. Freeman, Joseph H. Chan, George W. Koszalka, Leroy B. Townsend, John C. Drach
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Publication number: 20020058635Abstract: Novel purine L-nucleoside compounds are disclosed, in which both the purine rings and the sugar are either modified, functionalized, or both. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Th1 and Th2.Type: ApplicationFiled: October 30, 2001Publication date: May 16, 2002Inventor: Devron R. Averett
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Patent number: 6307043Abstract: The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.Type: GrantFiled: January 21, 2000Date of Patent: October 23, 2001Assignee: Glaxo Wellcome Inc.Inventors: Stanley Dawes Chamberlain, Jeffrey H. Tidwell
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Publication number: 20010011075Abstract: The present invention relates to polysubstituted benzimidazoles, having the following formula: 1Type: ApplicationFiled: February 5, 1999Publication date: August 2, 2001Inventors: LEROY B TOWNSEND, JOHN C DRACH
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Patent number: 6214801Abstract: This invention pertains to nucleoside analogs that have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to imidazo[1,2-a]pyridine C-nucleosides, as exemplified by compounds such as imidazo[l,2-a]pyridine C5-nucleosides and imidazo[1,2-a]pyridine C3-nucleosides, and may be represented by formula (I), wherein exactly one of Q3 and Q5 is a sugar-like moiety; exactly one of Q3 and Q5 is —H; and Q2, Q6, Q7 and Q8 are independently imidazo[1,2-a]pyridine substituents, such as —H, —F, —Cl, —Br and —I.Type: GrantFiled: May 17, 1999Date of Patent: April 10, 2001Assignee: The Regents of the University of MichiganInventors: Leroy B. Townsend, John C. Drach
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Patent number: 6204249Abstract: The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.Type: GrantFiled: July 13, 1998Date of Patent: March 20, 2001Assignee: Glaxo Wellcome Inc.Inventors: Stanley Dawes Chamberlain, George Walter Koszalka, Jeffrey H. Tidwell, Nanine Agneta Vandraanen