The Nitrogen Of The Hetero Ring Is Bonded Directly To Each Of The Two Benzene Rings (e.g., Iminodibenzyl, Etc.) Patents (Class 540/588)
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Patent number: 8779126Abstract: A dye, having a structure represented by formula (1A): wherein A represents a group of atoms necessary for forming a ring together with the carbon-nitrogen bond; at least one of Y1A and Y2A represents an acidic group, in which when they each represent an acidic group, they may be the same as or different from each other, or when only one of them represents an acidic group, the other represents an electron-withdrawing group; D represents a group to give a dye; n represents an integer of 1 or greater; L represents a single bond or a divalent linking group; and Y3A represents an acidic group.Type: GrantFiled: October 29, 2009Date of Patent: July 15, 2014Assignee: Fujifilm CorporationInventors: Katsumi Kobayashi, Keizo Kimura, Tatsuya Susuki, Hirotaka Satou, Yukio Tani
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Publication number: 20140102540Abstract: A dye, having a structure represented by formula (1A): wherein A represents a group of atoms necessary for forming a ring together with the carbon-nitrogen bond; at least one of Y1A and Y2A represents an acidic group, in which when they each represent an acidic group, they may be the same as or different from each other, or when only one of them represents an acidic group, the other represents an electron-withdrawing group; D represents a group to give a dye; n represents an integer of 1 or greater; L represents a single bond or a divalent linking group; and Y3A represents an acidic group.Type: ApplicationFiled: December 20, 2013Publication date: April 17, 2014Applicant: FUJIFILM CorporationInventors: Katsumi KOBAYASHI, Keizo KIMURA, Tatsuya SUSUKI, Hirotaka SATOU, Yukio TANI
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Publication number: 20130122276Abstract: A photoelectric conversion device comprising a transparent electrically conductive film, a photoelectric conversion film and an electrically conductive film in this order, wherein the photoelectric conversion film comprises a photoelectric conversion layer, and an electron blocking layer, wherein the electron blocking layer contains a compound represented by the specific formula.Type: ApplicationFiled: January 3, 2013Publication date: May 16, 2013Applicant: FUJIFILM CORPORATIONInventor: FUJIFILM Corporation
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Patent number: 8435979Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, and parasitic infections. The compounds are triphenyl methane analogs of imipramine blue and analogs thereof, as defined herein. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.Type: GrantFiled: December 21, 2009Date of Patent: May 7, 2013Assignees: Emory University, The United States of America as represented by the Dept of Veterans AffairsInventor: Jack L. Arbiser
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Publication number: 20130009136Abstract: The present invention relates to a triphenylene-based compound represented by the following Formula 1 and an organic electroluminescent device including the same, and the compound of the present invention has excellent hole injection and/or transporting ability, electron transporting ability, and/or light emitting ability, and particularly, green and red light emitting ability, and thus in an organic electroluminescent device containing the same as a light emitting host material, characteristics such as luminous efficiency, luminance, thermal stability, driving voltage, service life and the like may be improved. In the formula, each of A, L, X and R1 to R19 is the same as those as defined in Detailed Description.Type: ApplicationFiled: December 29, 2010Publication date: January 10, 2013Applicant: DOOSAN CORPORATIONInventors: Jin-Seok Hong, Chang-Ju Shin, Tae-Hyung Kim, Kyoung-Soo Kim
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Publication number: 20120206037Abstract: Provided are a novel organic electroluminescent compound and an organic electroluminescent device using the same. When used as a host material of an organic electroluminescent material of an OLED device, the organic electroluminescent compound disclosed herein exhibits good luminous efficiency and excellent life property as compared to the existing host material. Therefore, it may be used to manufacture OLEDs having very superior operation life.Type: ApplicationFiled: July 19, 2010Publication date: August 16, 2012Applicant: Rohm and Haas Electronic Materials Korea LtdInventors: Soo Young Lee, Young Gil Kim, Youngg Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
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Publication number: 20120091885Abstract: Disclosed are novel organic electroluminescent compounds and organic electroluminescent devices comprising the same. With good luminous efficiency and excellent life property, the disclosed organic electroluminescent compounds can be used to manufacture OLED devices having very good operation life.Type: ApplicationFiled: March 29, 2010Publication date: April 19, 2012Applicant: Rohm and Haas Electronic Materials Korea Let.Inventors: Young Gil Kim, Young Jun Chop, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
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Publication number: 20120077973Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.Type: ApplicationFiled: December 7, 2011Publication date: March 29, 2012Applicant: BIAL - PORTELA & CA, S.A.Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
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Publication number: 20110213144Abstract: A dye, having a structure represented by formula (1A): wherein A represents a group of atoms necessary for forming a ring together with the carbon-nitrogen bond; at least one of Y1A and Y2A represents an acidic group, in which when they each represent an acidic group, they may be the same as or different from each other, or when only one of them represents an acidic group, the other represents an electron-withdrawing group; D represents a group to give a dye; n represents an integer of 1 or greater; L represents a single bond or a divalent linking group; and Y3A represents an acidic group.Type: ApplicationFiled: October 29, 2009Publication date: September 1, 2011Applicant: FUJIFILM CORPORATIONInventors: Katsumi Kobayashi, Keizo Kimura, Tatsuya Susuki, Hirotaka Satou, Yukio Tani
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Publication number: 20110196147Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.Type: ApplicationFiled: April 4, 2011Publication date: August 11, 2011Inventors: Robert Déziel, Silvana Leit, Patrick Beaulieu, Yves Andre Chantigny, John Mancuso, Pierre Tessier, Gideon Shapiro, Richard Chesworth, David Smil
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Patent number: 7939183Abstract: Provided is a material for an organic electroluminescence device, which is composed of a compound having a specific structure; and is capable of providing an organic electroluminescence device having a high luminous efficiency, excellent heat resistance, and a long lifetime while having no pixel defects, and an organic electroluminescence device using the same. The organic electroluminescence device comprises an organic thin film layer composed of one or more layers including at least a light-emitting layer and sandwiched between a cathode and an anode. In the organic electroluminescence device, at least one layer of the organic thin film layer comprises the material for an organic electroluminescence device.Type: GrantFiled: December 24, 2004Date of Patent: May 10, 2011Assignee: Idemitsu Kosan Co., Ltd.Inventors: Toshihiro Iwakuma, Hisayuki Kawamura, Hidetsugu Ikeda, Chishio Hosokawa, Takashi Arakane, Hiroaki Nakamura
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Patent number: 7803786Abstract: The present invention comprises pharmaceutical compositions comprising a co-crystal of an API and a co-crystal former, and methods of making and using the same.Type: GrantFiled: June 16, 2005Date of Patent: September 28, 2010Assignees: Transform Pharmaceuticals, Inc., University of South FloridaInventors: Jennifer McMahon, Matthew Peterson, Michael J. Zaworotko, Tanise Shattock, Magali Bourghol Hickey
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Publication number: 20100160296Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, and parasitic infections. The compounds are triphenyl methane analogs of imipramine blue and analogs thereof, as defined herein. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.Type: ApplicationFiled: December 21, 2009Publication date: June 24, 2010Applicant: EMORY UNIVERSITYInventor: Jack L. Arbiser
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Publication number: 20100051106Abstract: Provided are novel organic electroluminescent compounds characterized in that they are represented by Chemical Formula (1): wherein, ring A and ring B independently represent a saturated 5- or 6-membered heterocyclic amino group, or a substituent selected from the following structures: wherein the saturated 5- or 6-membered heterocyclic amino group may further comprise one or more heteroatom(s) selected from NR36, O and S; and a and b independently represent an integer from 0 to 4, provided that (a+b) is an integer from 1 to 4.Type: ApplicationFiled: June 23, 2009Publication date: March 4, 2010Applicant: Gracel Display Inc.Inventors: Chi Sik Kim, Young Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
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Publication number: 20100032658Abstract: Provided are novel organic electroluminescent compounds and organic electroluminescent devices comprising the same as electroluminescent material. Specifically, the organic electroluminescent compounds according to the invention are characterized in that they are represented by Chemical Formula (1): wherein, L is selected from the following structures. The organic electroluminescent compounds according to the invention exhibit high luminous efficiency in blue color and excellent life property as a material, so that an OLED having very good operation life can be prepared therefrom.Type: ApplicationFiled: July 13, 2009Publication date: February 11, 2010Applicant: Gracel Display Inc.Inventors: Hyo Jung Lee, Young Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
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Publication number: 20090176745Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.Type: ApplicationFiled: December 29, 2008Publication date: July 9, 2009Applicant: Emory UniversityInventor: Jack L. Arbiser
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Publication number: 20090176760Abstract: The present invention provides a PPAR ? agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH?CH—CH?CH or the like, Y represents a single bond or the like, Z1-Z2 represents C?CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.Type: ApplicationFiled: February 7, 2008Publication date: July 9, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Arata Yanagisawa, Takeshi Kuboyama, Seiji Aratake, Kazuki Hemmi, Kimihisa Ueno, Michihiko Suzuki, Masahiro Matsubara, Kozo Yao, Akinori Hamaguchi, Yukihito Tsukumo
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Patent number: 7527878Abstract: An organic electroluminescence element, which contains at least one organic layer that includes a luminescent layer between a pair of electrodes, wherein the organic layer contains at least one compound represented by formula (1): wherein R11 and R12 each independently represent an aryl or heteroaryl group; when R11 or R12 is a phenyl group, it has no nitrogen-containing heterocyclic group on R11 or R12 as a substituent; Ar11 and Ar12 each independently represent a group represented by formula (2): wherein Ar21 represents an arylene or heteroarylene group; R21, R22, R23, and R24 each independently represent a substituent or a hydrogen atom; L2 represents a substituted or unsubstituted o-arylene or vinylene group, —NR— (R represents a substituent), —O—, or —S—; and m is 0 or 1.Type: GrantFiled: March 22, 2005Date of Patent: May 5, 2009Assignee: Fujifilm CorporationInventors: Jun Ogasawara, Saisuke Watanabe
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Publication number: 20090058289Abstract: The present invention relates to triaylamines which are substituted by defined groups. These compounds can be used for producing organic electroluminescent devices.Type: ApplicationFiled: March 3, 2007Publication date: March 5, 2009Applicant: MERCK PATENT GMBHInventors: Philipp Stoessel, Holger Heil, Arne Buesing
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Publication number: 20090012057Abstract: The invention describes compositions and kits comprising at least one cardiovascular compound comprising at least one nitric oxide enhancing group, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; Q) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension; (n) treating ophthalmic disorders; (o) treating metabolic syndrome; and (p) treating hyperlipidemia.Type: ApplicationFiled: February 28, 2006Publication date: January 8, 2009Applicant: NitroMed, Inc.Inventor: David S. Garvey
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Patent number: 7465721Abstract: A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive oxygen species useful for treating inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.Type: GrantFiled: December 8, 2004Date of Patent: December 16, 2008Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Serge Auvin, Pierre-Etienne Chabrier de Lassauniere
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Publication number: 20080146544Abstract: The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.Type: ApplicationFiled: February 25, 2008Publication date: June 19, 2008Inventors: Timothy L. MacDonald, Jerry L. Nadler, Peng Cui
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Publication number: 20080138654Abstract: A hole transporting or hole conducting material for use in electroluminescent devices is a diamino dianthracene.Type: ApplicationFiled: December 6, 2005Publication date: June 12, 2008Applicant: OLED-T LimtedInventors: Poopathy Kathirgamanathan, Alexander Kit Lay, Muttulingam Kumaraverl, Subramaniam Ganeshamurugan
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Patent number: 7384933Abstract: A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive oxygen species useful for treating inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.Type: GrantFiled: April 27, 2005Date of Patent: June 10, 2008Assignee: Societe de Conseils de Recherches Et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Serge Auvin, Pierre-Etienne Chabrier De Lassauniere
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Publication number: 20080122346Abstract: Provided is an anthracene derivative compound represented by Formula 1 below and an organic light-emitting device using the same: wherein Ar1, Ar2, R1, R2, R?, m, n, j, k, and X are as defined in the specification. The anthracene derivative compound is advantageously used in the production of an organic light-emitting device with better driving voltage, efficiency, and color purity.Type: ApplicationFiled: August 2, 2007Publication date: May 29, 2008Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Yi-yeol Lyu, Jhun-mo Son, Das Rupasree Ragini, Byoung-ki Choi
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Publication number: 20070176541Abstract: A compound represented by Formula 1 and an organic light emitting device including the same: where Ar is a substituted or unsubstituted C6-C26 aryl group; X is O, S, R1 and R2 are hydrogen, a halogen, a C1-C12 alkyl group, a C6-C26 aryl group, or a substituted group thereof; R3, R4, R5, R6, R7 and R8 are each independently hydrogen or a substituted or unsubstituted C1-C12 alkyl group; R9 through R22 are each independently hydrogen, a C1-C30 alkyl group, a C1-C30 alkoxy group, a C6-C30 aryl group, a C6-C30 arylalkyl group, a C6-C30 aryloxy group, a C5-C30 heteroaryl group, a C5-C30 heteroarylalkyl group, a C5-C30 heteroaryloxy group, a C5-C20 cycloalkyl group, a C5-C30 heterocycloalkyl group, or a substituted group thereof. An organic light emitting device using the compound has low operating voltage, high color purity, and high efficiency.Type: ApplicationFiled: December 7, 2006Publication date: August 2, 2007Inventors: Jhun-Mo Son, Eun-Sun Yu, O-Hyun Kwon, Young-Mok Son, Yu-Jin Kim
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Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof
Patent number: 7056911Abstract: The invention relates to pharmaceutically active compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention and particularly useful for the treatment or prophylaxis of diseases associated with parasitic infection such as pneumocystis pneumonia, toxoplasmosis, cryptosporidiosis, leischmaniasis and malaria.Type: GrantFiled: January 25, 2000Date of Patent: June 6, 2006Assignee: Dana-Farber Cancer InstituteInventor: Andre Rosowsky -
Patent number: 6955856Abstract: A biphenyl derivative having an amino group with or without alkoxy substituent in the biphenyl backbone, and an organic electroluminescent device using the same.Type: GrantFiled: December 30, 2003Date of Patent: October 18, 2005Assignee: Samsung SDI Co., Ltd.Inventors: Soo-hyoung Lee, Ji-hoon Lee, Sang-yeol Kim, Byung-hee Sohn, Jhun-mo Son
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Patent number: 6930183Abstract: Disclosed herein is an antioxidant that is an alkylated iminodibenzyl of the general formula: wherein: R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, alkyl moieties, and alkenyl moieties; and R5, R6, R7, and R8 are independently selected from the group consisting of hydrocarbyl moieties and hydrogen.Type: GrantFiled: April 17, 2003Date of Patent: August 16, 2005Assignee: Crompton CorporationInventors: Karl J. Duyck, Theodore E. Nalesnik
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Publication number: 20040214040Abstract: A biphenyl derivative having an amino group with or without alkoxy substituent in the biphenyl backbone, and an organic electroluminescent device using the same.Type: ApplicationFiled: December 30, 2003Publication date: October 28, 2004Inventors: Soo-hyoung Lee, Ji-hoon Lee, Sang-yeol Kim, Byung-hee Sohn, Jhun-mo Son
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Publication number: 20040167118Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc.Type: ApplicationFiled: February 27, 2004Publication date: August 26, 2004Applicant: AJINOMOTO CO., INC.Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
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Publication number: 20030229073Abstract: The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond; Y=O, (CH2)m, S, SO, SO2, NH, NR8; Z=NH, O, NR8, S, SO, SO2. The remaining substituents are described in the specification.Type: ApplicationFiled: July 5, 2002Publication date: December 11, 2003Inventors: Richard John Booth, Vara Prasad Venkata Nagendra Josyula, Annette Lynn Meyer, Bruce Allan Steinbaugh
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Publication number: 20030171358Abstract: The present invention relates to compounds of the general formula (I) 1Type: ApplicationFiled: January 27, 2003Publication date: September 11, 2003Inventors: Lone Jeppesen, Per Sauerberg, Anthony Murray, Paul Stanley Bury
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Publication number: 20030096805Abstract: Methods and compositions of antidepressants and analogs thereof for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful for treating a localized pain.Type: ApplicationFiled: April 4, 2002Publication date: May 22, 2003Inventors: Ging Kuo Wang, Peter Gerner, Donald K. Verrecchia
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Publication number: 20020091120Abstract: Compounds, compositions, and methods for treating multidrug resistance are disclosed. Suitable compounds are 2-substituted heterocyclic compounds.Type: ApplicationFiled: December 19, 2000Publication date: July 11, 2002Inventors: Charles Raymond Degenhardt, David Joseph Eickhoff
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Publication number: 20020072516Abstract: Compounds of formula (I) 1Type: ApplicationFiled: August 29, 2001Publication date: June 13, 2002Inventors: Gang Liu, Bruce G. Szczepankiewicz, Zhonghua Pei, Zhili Xin, David A. Janowick
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Publication number: 20020065267Abstract: The present invention relates to compounds of the general formula (I) 1Type: ApplicationFiled: November 27, 2001Publication date: May 30, 2002Inventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
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Publication number: 20020061876Abstract: The present invention relates to compounds of the general formula (I) 1Type: ApplicationFiled: November 27, 2001Publication date: May 23, 2002Inventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
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Publication number: 20020057050Abstract: The present invention relates to a novel class of thermostable hole-injection and hole-transport compounds having tunable glass transition temperatures and ionization potentials for use in organic light emitting diode (“OLED”) devices. In particular, the compounds of the present invention comprise a trityl aniline core structure with various substituents attached to the nitrogen group, the structures of which allow for the adjustment of the glass transition temperatures and ionization potentials of the compounds. The present invention also relates to microdisplay devices comprising the compounds of the present invention in the hole-injection/hole-transport layers.Type: ApplicationFiled: June 28, 2001Publication date: May 16, 2002Inventor: Xiaobo Shi
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Publication number: 20020035104Abstract: Provided are compounds of formula (I) 1Type: ApplicationFiled: August 16, 2001Publication date: March 21, 2002Applicant: GENENTECH, INC.Inventors: Dean R. Artis, David Y. Jackson, Thomas E. Rawson, Mark E. Reynolds, Daniel P. Sutherlin, Mark S. Stanley
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Publication number: 20020010171Abstract: The present invention relates to compounds of the general formula (I) 1Type: ApplicationFiled: June 11, 2001Publication date: January 24, 2002Inventors: Lone Jeppesen, Per Sauerberg, Anthony Murray, Paul Stanley Bury
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Publication number: 20010029256Abstract: The present invention relates to compounds of formula (I) 1Type: ApplicationFiled: March 14, 2001Publication date: October 11, 2001Inventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
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Patent number: 6008213Abstract: Compounds of formula (I) ##STR1## wherein A.sub.1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R.sup.3 or R.sup.4 ; X.sup.1 --X.sup.2 is CHR.sup.1 --CH, CR.sup.1 .dbd.CH, NR.sup.1 --CH, S(O).sub.u --CH or O--CH; X.sup.3 is CR.sup.5 R.sup.5 ', NR.sup.5, S(O).sub.u or O; R.sup.2 is --OR', --NR'R", --NR'SO.sub.2 R'", --NR'OR', --OCR'.sub.2 C(O)OR', --OCR'.sub.2 OC(O)--R', --OCR'.sub.2 C(O)NR'.sub.2, CF.sub.3 or --COCR'.sub.2 R.sup.2 '; R.sup.3, R.sup.4 and R.sup.7 are independently H, halo, --OR.sup.12, --SR.sup.12, --CN, --NR'R.sup.12, --NO.sub.2, --CF.sub.3, CF.sub.3 S(O).sub.r --, --CO.sub.2 R', --CONR'.sub.2, R.sup.14 --C.sub.0-6 alky-, R.sup.14 --C.sub.1-6 oxoalkyl-, R.sup.14 --C.sub.2-6 alkenyl-, R.sup.14 --C.sub.2-6 alkynyl-, R.sup.14 --C.sub.0-6 alkyloxy-, R.sup.14 --C.sub.0-6 alkylamino- or R.sup.14 --C.sub.0-6 alkyl--S(O).sub.r --; R.sup.6 is W--(CR'.sub.2).sub.q --Z--(CR'R.sup.10)--U--(CR'.sub.2).sub.s --V-- or W'--(CR'.sub.2).sub.Type: GrantFiled: December 19, 1997Date of Patent: December 28, 1999Assignee: SmithKline Beecham CorporationInventors: William E. Bondinell, William H. Miller
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Patent number: 5998399Abstract: Method of treating or reducing the risk of human disease or condition in which the synthesis or oversynthesis of nitric oxide forms a contributory part wherein a therapeutically effective amount of the compound of formula (I) as defined in the specification is administered to a person suffering from or susceptible to such disease or condition.Type: GrantFiled: November 16, 1998Date of Patent: December 7, 1999Assignee: Astra AktiebolagInventors: James E. Macdonald, Robert Gentile, Robert J. Murray
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Patent number: 5929235Abstract: An aromatic tertiary amine compound of formula (I): ##STR1## wherein (A) and (B) are each a substituted or unsubstituted vinylene or o-arylene group; R.sup.1 to R.sup.4 are each a halogen atom, or a substituted or unsubstituted alkyl, aryl, alkoxy, aryloxy, dialkylamino, N-alkyl-N-arylamino or diarylamino group; R.sup.5 is a halogen atom, or a substituted or unsubstituted alkyl, alkoxy or dialkylamino group; h, i, j, k and l are each an integer of 0-4; and m is an integer of 1-6.Type: GrantFiled: August 19, 1997Date of Patent: July 27, 1999Assignee: Fuji Photo Film Co., Ltd.Inventor: Tadahisa Sato
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Patent number: 5916889Abstract: The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.Type: GrantFiled: October 3, 1997Date of Patent: June 29, 1999Assignee: Novo Nordisk A/SInventors: Rolf Hohlweg, Peter Madsen, Tine Krogh J.o slashed.rgensen, Knud Erik Andersen, Brett Watson, Zdenek Polivka, Otylie Konigova, Martina Kovandova, Alexandra Silhankova, Vladimir Valenta
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Patent number: 5895815Abstract: Process for the purification of 5H-dibenz?b,f!a-zepine, which comprises evaporating 5H-dibenz?b, f!azepine under reduced pressure from a reaction mixture obtained by catalytic dehydrogenation of 10,11-dihydro-5H-dibenz-?b,f!azepine in the 1st step and depositing it as a solid, suspending the deposited product in an aromatic hydrocarbon in the 2nd step and then isolating pure 5H-dibenz?b,f!azepine.Type: GrantFiled: October 2, 1997Date of Patent: April 20, 1999Assignee: DSM Chemie Linz GmbHInventors: Gunter Eichberger, Walter Raml
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Patent number: RE37029Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: November 5, 1998Date of Patent: January 23, 2001Assignee: Aventis Pharmaceuticals Inc.Inventors: Joseph T. Strupczewski, Edward J. Glamkowski, Yulin Chiang, Kenneth J. Bordeau, Peter A. Nemoto, John J. Tegler
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Patent number: RE37729Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: February 3, 1999Date of Patent: June 4, 2002Assignee: Aventis Pharmaceuticals Inc.Inventors: Edward J. Glamkowski, Yulin Chiang, Joseph T. Strupczewski, Kenneth J. Bordeau, Peter A. Nemoto, John J. Tegeler
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Patent number: RE39265Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: November 9, 2000Date of Patent: September 5, 2006Assignee: Aventis Pharmaceuticals Inc.Inventors: Joseph T. Strupczewski, Kenneth J. Bordeau, Edward J. Glamkowski, Yulin Chiang, Grover C. Helsley