Polycyclo-carbocyclic Ring System Having At Least Three Cyclos Patents (Class 548/160)
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Patent number: 9383353Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: GrantFiled: June 17, 2014Date of Patent: July 5, 2016Assignee: Sirigen Inc.Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell Baldocchi
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Publication number: 20150118162Abstract: The present disclosure relates to a two-photon fluorescent dye for imaging total sulfide in vivo and a method for quantitatively estimating total sulfide concentration in vivo using the same. The two-photon fluorescent dye, which includes a compound of [Chemical Formula 1], can detect hydrosulfide on and image total sulfide and allows quantitative estimation of total sulfide concentration in vivo.Type: ApplicationFiled: August 14, 2014Publication date: April 30, 2015Inventor: Bong-Rae Cho
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Publication number: 20140239269Abstract: A pyrene-based compound, and an organic light-emitting diode including the pyrene-based compound are provided.Type: ApplicationFiled: August 5, 2013Publication date: August 28, 2014Inventors: Eun-Jae Jeong, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jun-Ha Park, Eun-Young Lee, Jin-O Lim, Sang-Hyun Han, Soo-Yon Kim, Jong-Hyuk Lee
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Publication number: 20140197393Abstract: The present invention relates to a hydrocarbon-based fused ring compound and an organic light emitting device including the same.Type: ApplicationFiled: December 20, 2013Publication date: July 17, 2014Applicant: HEESUNG MATERIAL LTD.Inventors: Jun-A LEE, Geon-Yu PARK, Jeong-Hoon YANG, Sung-Jin EUM, Joo-Dong LEE
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NOVEL ORGANOMETALLIC COMPLEXES WHICH EMIT IN THE RED TO GREEN SPECTRAL REGION AND THEIR USE IN OLEDS
Publication number: 20130231489Abstract: Organometallic complexes which bear at least one ligand which has a unit having a triplet energy of at least 22 000 cm?1, a process for preparing the organometallic complexes, a mixture comprising at least one inventive organometallic complex, the use of the organometallic complexes or of the mixture in organic light-emitting diodes, the organometallic complexes preferably being used as emitter materials, and specific nitrogen- or phosphorus-substituted triphenylene derivatives and a process for their preparation.Type: ApplicationFiled: April 16, 2013Publication date: September 5, 2013Applicant: BASF SEInventors: Herbert Friedrich BOERNER, Hans-Peter LOEBL, Josef SALBECK, Elena POPOVA -
Patent number: 8524697Abstract: The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: wherein L, R1, R2, R3, R4, R5, and R6 are selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas II, III, IV, V, and VI, as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.Type: GrantFiled: December 18, 2008Date of Patent: September 3, 2013Assignee: Merck Sharp & Dohme Corp.Inventors: John C. Anthes, Kevin D. McCormick, John A. Hey, Robert G. Aslanian, Purakkattle J. Biju, Michael Y. Berlin, Hongwu Yang, Yeon-Hee Lim, Yoon Joo Lee, Rema Danielle Bitar, Phillippa H. Solomon
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Patent number: 8298683Abstract: The present invention provides an organic light emitting device comprising a first electrode, at least one organic layer and a second electrode, laminated successively, in which at least one layer of the organic layer has a polycyclic aromatic hydrocarbon as a core and comprises at least one of a derivative in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is directly fused to the core or fused to a substituent of the core; and a new organic compound usable in the organic light emitting device. Furthermore, the present invention provides a charge carrier extracting, injecting or transporting material which has a polycyclic aromatic hydrocarbon as a core and comprises a derivative in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is directly fused to the core or fused to a substituent of the core.Type: GrantFiled: September 14, 2006Date of Patent: October 30, 2012Assignee: LG Chem, Ltd.Inventors: Kong Kyeom Kim, Sung Kil Hong, Hye Young Jang, Dong Seob Jeong
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Patent number: 8168327Abstract: An imide derivative represented by the following formula (A): wherein Ra and Rb are each a hydrogen atom, a halogen atom, a cyano group, an alkyl group, a fluoroalkyl group or an aryl group; at least one of Ra and Rb is a fluoroalkyl group; and Rc and Rd are each a substituted or unsubstituted benzyl group, an aryl group, a heterocycle, a fluoroalkyl group or an imide group.Type: GrantFiled: January 4, 2007Date of Patent: May 1, 2012Assignee: Idemitsu Kosan Co., Ltd.Inventors: Hironobu Morishita, Hisayuki Kawamura, Chishio Hosokawa
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Patent number: 8153812Abstract: Provided are new 2PA chromophores of the formula: wherein X=para- or meta-NO2; para- or meta-NH2; and CnHn+1 is either a straight or branched alkyl chain, and n is an integer from 1-20.Type: GrantFiled: February 23, 2011Date of Patent: April 10, 2012Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Loon-Seng Tan, Ramamurthi Kannan, Matthew J. Dalton
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Publication number: 20110182828Abstract: The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: wherein L, R1, R2, R3, R4, R5, and R6 are selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas II, III, IV, V, and VI, as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.Type: ApplicationFiled: December 18, 2008Publication date: July 28, 2011Applicant: Schering CorporationInventors: John C. Anthes, Kevin D. Mccormick, John A. Hey, Robert G. Aslanian, Purakkattle J. Biju, Michael Y. Berlin, Daniel M. Solomon, Phillippa H. Solomon, Hongwu Yang, Yeon-Hee Lim, Yoon Joo Lee, Rema Danielle Bitar
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Publication number: 20100187505Abstract: The present invention relates to the compounds of the formula (1) and to organic electroluminescent devices, in particular blue-emitting devices, in which these compounds are used as host material or dopant in the emitting layer and/or as hole-transport material and/or as electron-transport material.Type: ApplicationFiled: April 29, 2008Publication date: July 29, 2010Inventors: Philipp Stoessel, Arne Buesing, Holger Heil
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THIAZOLE SYSTEM ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC LIGHT EMITTING DIODE USING THE SAME
Publication number: 20100190994Abstract: The present invention relates to novel thiazole system organic electroluminescent compounds and organic light emitting diodes comprising the same. Since the thiazole system organic electroluminescent compounds according to the invention have good luminous efficiency and life property, OLED's having very good operation lifetime can be produced.Type: ApplicationFiled: March 25, 2008Publication date: July 29, 2010Inventors: Mi Ae Lee, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon -
Publication number: 20090184235Abstract: A merocyanine dye is provided. The merocyanine dye is represented by formula (1). In the formula (1), A1 represents a divalent atomic group, n represents an integer of 1 to 3, A2 and A3 each independently represent an aromatic hydrocarbon ring or a heterocyclic ring having 3 to 18 carbon atoms, and R11 and R12 each independently represent a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, an aryl group having 6 to 18 carbon atoms, or a heterocyclic group having 3 to 18 carbon atoms.Type: ApplicationFiled: January 16, 2009Publication date: July 23, 2009Applicant: FUJIFILM CORPORATIONInventors: Kimiatsu NOMURA, Rui SHEN, Hideyuki SUZUKI
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Publication number: 20090170914Abstract: A compound of formula (I) wherein R1 is a straight chain, branched or cyclic aliphatic, aromatic or heterocyclyl group comprising at least 8 carbon atoms, e.g. 8 to 22, R2 is a straight chain, branched or cyclic aliphatic, aromatic or heterocyclic group comprising from 1 to 12 carbon atoms, and ring A is heterocycyl, fused with the phenyl ring to which ring A is attached comprising 5 or 6 ring members, and 1 to 4 heteroatoms selected from N, S, O; wherein certain compounds are excluded by proviso and the use of such compounds without proviso as pharmaceuticals in disorders which are mediated by ceramide kinase.Type: ApplicationFiled: March 28, 2007Publication date: July 2, 2009Inventors: Frederic Bornancin, Berndt Oberhauser
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Publication number: 20090091252Abstract: The present invention provides a novel binaphthyl compound and an organic light emitting element having a good light emitting efficiency and a high durability at a low driving voltage.Type: ApplicationFiled: October 2, 2008Publication date: April 9, 2009Applicant: CANON KABUSHIKI KAISHAInventors: Tetsuya Kosuge, Jun Kamatani, Shigemoto Abe, Ryota Ooishi, Kengo Kishino
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Publication number: 20090042929Abstract: There is provided a compound having Formula (I) R1-Z-R2 wherein R1 is a group selected from optionally substituted fused polycyclic groups, substituted alkyl groups, branched alkyl groups, and optionally substituted cycloalkyl groups Z is a linker which is or comprises a carbonyl group or a isostere of a carbonyl group R2 is selected from optionally substituted aromatic rings and optionally substituted heterocyclic rings wherein (a) R2 is a 2-substituted thiophene group, and/or (b) Z is a group of the formula —C(?O)—CR3R4—X—(CR5R6)n-, wherein X is selected from NR7, S, O, S?O, and S(?O)2, wherein n is 0 or 1 and/or (c) R1 is an adamantyl group and Z is or comprises an amide group, and/or (d) R1 is an adamantyl group and Z is or comprises a group of the formula —(CR8R9)p-NR10—S(?O)2—(CR11R12)q-, wherein p is 0 or 1 and q is 0 or 1 and/or (e) R1 is an adamantyl group and Z is or comprises a group of the formula —(CR13R14)V—Y—(CR15R16)W— where Y is a heteroaryl group in which a bond in the heteroaryl ring is a iType: ApplicationFiled: March 23, 2006Publication date: February 12, 2009Applicant: Sterix LimitedInventors: Nigel Vicker, Xiangdong Su, Fabienne Pradaux, Michael John Reed, Barry Victor Lloyd Potter
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Publication number: 20080166593Abstract: The present invention relates to the use of certain organic compounds comprising fused aromatic compounds in organic electronic devices, in particular electroluminescent devices.Type: ApplicationFiled: March 20, 2006Publication date: July 10, 2008Inventors: Philipp Stoessel, Holger Heil, Horst Vestweber
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Patent number: 7385095Abstract: The present invention provides an indene derivatives having a new structure and an organic light-emitting diode using the same. The organic light-emitting diode according to the present invention shows improved effects in efficiency, driving voltage and stability.Type: GrantFiled: October 19, 2006Date of Patent: June 10, 2008Assignee: LG Chem, Ltd.Inventors: Dae Woong Lee, Jae Soon Bae, Dong Hoon Lee, Kong Kyeom Kim
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Patent number: 7317024Abstract: The invention relates to a class of novel non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-?B activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or stereoisomers or prodrugs or solvates or pharmaceutically acceptable salts thereof, wherein Z, R, R4, R5, Ra, Rb, Rc, and Rd, are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.Type: GrantFiled: January 12, 2006Date of Patent: January 8, 2008Assignee: Bristol-Myers Squibb Co.Inventor: Bingwei V. Yang
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Publication number: 20070205412Abstract: The present invention provides a novel anthracene derivative and an organic electronic device using the same. The organic electronic device according to the present invention shows excellent characteristics in efficiency, drive voltage, and life time.Type: ApplicationFiled: March 6, 2007Publication date: September 6, 2007Inventors: Jae-Soon Bae, Dae-Woong Lee, Dong-Hoon Lee, Jun-Gi Jang, Sang-Young Jeon, Ji-Eun Kim
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Patent number: 7253287Abstract: Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon based imaging, a new series of reactive fluorophores tailored for multiphoton imaging has been disclosed. These fluorophores are based upon the fluorene ring system, known to exhibit high fluorescence quantum yields, typically >0.7, and possess high photostability. They have been functionalized with moieties to act, e.g., as efficient amine-reactive fluorescent probes for the covalent attachment onto, e.g., proteins and antibodies. The synthesis and the single-photon spectral characteristics, as well as measured two-photon absorption cross sections of the reactive fluorophores in solution are presented. Spectral characterizations of bovine serum albumin (BSA) conjugated with the new reactive probe is presented.Type: GrantFiled: May 13, 2005Date of Patent: August 7, 2007Assignee: Research Foundation of The University of Central Florida, Inc.Inventors: Kevin D. Belfield, Katherine J. Schafer
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Patent number: 7217706Abstract: This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic, anti-urinary incontinence and anti-pollakiuria activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.Type: GrantFiled: February 14, 2002Date of Patent: May 15, 2007Assignee: Astellas Pharma Inc.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Naoaki Fujii, Kumi Hosoi, Yasuyo Tomishima, Hisashi Takasugi, Hajime Sogabe, Hirofumi Ishikawa, Naomi Hanioka
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Patent number: 7067674Abstract: Provided are chromophores of the formula: wherein R is an alkyl group having 1 to 20 carbon atoms, and Q is —(CH2)n—Br, and wherein n has a value of 2–6.Type: GrantFiled: February 23, 2004Date of Patent: June 27, 2006Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Ramamurthi Kannan, Loon-Seng Tan
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Patent number: 7001708Abstract: Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a photoinduced acid generator upon exposure to a broad-band UV light source or fast-pulsed red to near-IR laser irradiation. Solution studies demonstrated formation of monoprotonated and diprotonated species upon irradiation, each resulting in distinctly different absorption and fluorescence properties. The fluorescence of the original, neutral, fluorophore was reduced upon monoprotonation, leading to a concomitant increase in fluorescence at longer wavelengths due to the monoprotonated form, the basis for multichannel data readout.Type: GrantFiled: November 27, 2002Date of Patent: February 21, 2006Assignee: University of Central Florida Research Foundation, Inc.Inventor: Kevin D. Belfield
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Patent number: 6995181Abstract: Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure where Z is CONR1R2 or CH2NR1R2 and where R, Ra, Rb, Rc, Rd, Z, A and B are defined herein.Type: GrantFiled: July 17, 2003Date of Patent: February 7, 2006Assignee: Bristol-Myers Squibb Co.Inventors: Wayne Vaccaro, Bingwei Vera Yang, Soong-Hoon Kim, Tram Huynh, David R. Tortolani, Kenneth J. Leavitt, Wenying Li, Arthur M. Doweyko, Xiao-Tao Chen, Lidia Doweyko
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Patent number: 6867304Abstract: Provided are new TPA chromophores of the formula: wherein R is an alkyl group having 1 to 20 carbon atoms and Q is —C6H13, —CH2—C6H5, or —C6H11.Type: GrantFiled: February 23, 2004Date of Patent: March 15, 2005Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Loon-Seng Tan, Ramamurthi Kannan
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Patent number: 6852548Abstract: Chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature, represented by the formulas I or II: wherein T is:Type: GrantFiled: September 5, 2001Date of Patent: February 8, 2005
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Patent number: 6800380Abstract: An organometallic luminescent material comprising the compound of formula (I) of the present invention can emit pure blue light and have high thermal stability: wherein, M1 is a monovalent or tetravalent metal selected from the group consisting of Li, Na, K, Zr, Si, Ti, Sn, Cs, Fr, Rb, Hf, Pr, Pa, Ge, Pb, Tm and Md; R is hydrogen or C1-10 alkyl; B is O, S, Se or Te; D is O or S; and n is an integer ranging from 1 to 4.Type: GrantFiled: November 26, 2001Date of Patent: October 5, 2004Assignee: Nessdisplay Co., Ltd.Inventors: Youngkyoo Kim, Jae-Gyoung Lee
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Patent number: 6756375Abstract: The invention provides for a non-steroidal compound having the formula wherein Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2— or —CH2CH2—; R1 is H, halogen, CF3, or (1C-4C)alkyl; R2, R3 and R4 are independently H, halogen, —CF3, —OCF3, (1C-8C)Alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH2)mX, wherein X is halogen or phenyl and m=2-4; —O(CH2)mNRaRb, —S(CH2)mNRaRb or —(CH2)mNRaRb, wherein m=2-4 and Ra, Rb are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl or Ra and Rb form a 3-8 membered ring structure, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, hydroxy, hydroxy(1C-4C)aType: GrantFiled: July 24, 2003Date of Patent: June 29, 2004Assignee: Akzo Nobel N.V.Inventors: Gerrit Herman Veeneman, Hubert JanJozef Loozen, Jordi Mestres, Eduard Willem De Zwart
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Patent number: 6635634Abstract: This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic, anti-urinary incontinence and anti-pollakiuria activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.Type: GrantFiled: February 14, 2002Date of Patent: October 21, 2003Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Naoaki Fujii, Kumi Hosoi, Yasuyo Tomishima, Hisashi Takasugi, Hajime Sogabe, Hirofumi Ishikawa, Naomi Hanioka
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Patent number: 6495546Abstract: Propanolamine derivatives represented by the following formula (I): These derivatives may be &bgr;3 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria activities. Pharmaceutical compositions containing such propanolamine derivatives, methods for the prevention and/or treatment diseases using these propanolamine derivatives, and processes for their preparation are also described.Type: GrantFiled: November 22, 2000Date of Patent: December 17, 2002Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Naoaki Fujii, Kumi Hosoi, Yasuyo Tomishima, Hisashi Takasugi, Hajime Sogabe, Hirofumi Ishikawa, Naomi Hanioka
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Patent number: 6458908Abstract: A sulfur-containing unsaturated carboxylate compound comprising a sulfur-containing substituent and at least two &agr;,&bgr;-unsaturated carboxylic acid residues, which are each attached to a secondary or tertiary carbon atom via an oxygen atom; a polymerizable composition comprising the sulfur-containing unsaturated carboxylate compound; a cured product prepared by polymerizing the polymerizable composition; an optical component consisting of the cured product; and novel intermediate compounds for preparation of the above carboxylate.Type: GrantFiled: May 31, 2000Date of Patent: October 1, 2002Assignee: Mitsui Chemicals, Inc.Inventors: Masao Imai, Kenichi Sugimoto, Kenichi Fujii, Atsuo Otsuji, Tadashi Ohkuma, Masatoshi Takagi, Rihoko Suzuki, Keisuke Takuma
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Publication number: 20020103171Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.Type: ApplicationFiled: March 30, 2001Publication date: August 1, 2002Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd E. Bowser, Mohamed Y. Ismail
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Patent number: 6300502Abstract: Provided are chromophores with very large two-photon absorption cross-sections. One group of these chromophores has the formula: (T—Q)n—N—Phm wherein Q is a single bond or 1,4-phenylene, Ph is a phenyl group, n has a value of 1-3 and m has a value of 3−n, and wherein T is wherein R1 and R2 are alkyl groups having 1 to 20 carbon atoms, provided that when Q is a single bond, the value of n is 2 or 3. Another group of these chromophores has the formula: (T—Q)n—G—Phm wherein T is as defined above, Q is a single bond or 1,4-phenylene, Ph is a phenyl group, n has a value of 1-4 and m has a value of 4−n, and wherein G is a 4-arm core unit. Yet another group of these chromophores has the formula: (T—Q)n—G—Phm wherein T is as described previously, Q is a single bond or 1,4-phenylene, Ph is a phenyl group, n has a value of 1-6 and m has a value of 6−n, and wherein G is a 6-arm core unit.Type: GrantFiled: December 8, 2000Date of Patent: October 9, 2001Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Ramamurthi Kannan, Bruce A. Reinhardt, Loon-Seng Tan
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Patent number: 6214851Abstract: This invention relates generally to N-adamant-1-yl-N′-[4-chlorobenzothiazol-2-yl] urea, pharmaceutical compositions comprising the same, and methods of using the same in the treatment of inflammation and as an anticancer radiosensitizing agent.Type: GrantFiled: March 17, 2000Date of Patent: April 10, 2001Assignee: DuPont Pharmaceuticals CompanyInventors: John J. V. Duncia, Daniel S. Gardner, IV, Joseph B Santella, III
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Patent number: 6130217Abstract: This invention relates to certain heterocyclic compounds and their pharmaceutically acceptable salts, which are useful for sensitizing multidrug-resistant tumor cells to anticancer agents and multidrug resistant forms of malaria, tuberculosis, leishmania and amoebic dysentery to chemotherapeutants. The compounds and their pharmaceutically acceptable salts are also inhibitors of the active drug transport capability of P-glycoprotein which is encoded by the human MDR1 gene, as well as of certain other related ATP-binding-cassette transporters from eukaryotic and prokaryotic organisms (e.g., pfmdr from Plasmodium falciprum, and murine mdr1 and mdr3 gene products).Type: GrantFiled: September 20, 1995Date of Patent: October 10, 2000Assignee: Pfizer IncInventors: Lee Daniel Arnold, Jotham Wadsworth Coe, Takushi Kaneko, Mikel Paul Moyer
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Patent number: 6100405Abstract: There are provided asymmetrical two-photon chromophores of the formula:D--Ar--Awherein Ar is selected from the group consisting of ##STR1## wherein Fl is a fluorene group of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are alkyl groups having 2 to 20 carbon atoms, and wherein R.sub.1 and R.sub.2 are the same or different;wherein D is ##STR3## wherein Q is selected from the group consisting of --H, --OH and --O--C.sub.x H.sub.2x+1, wherein x has a value of 1 to 10;and wherein A is selected from the group consisting of ##STR4## wherein Z is selected from the group consisting of --O-- and --S--.Type: GrantFiled: June 15, 1999Date of Patent: August 8, 2000Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Bruce A. Reinhardt, deceased, by Erin D. Reinhardt, administrator, by Jason A. Reinhardt, administrator, Ramamurthi Kannan
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Patent number: 5698728Abstract: Novel alkene intermediates useful in the preparation of 1,2-dioxetanes.Type: GrantFiled: May 15, 1995Date of Patent: December 16, 1997Assignee: Board of Governors of Wayne State UniversityInventors: Arthur Paul Schaap, Hashem Akhavan-Tafti
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Patent number: 5189165Abstract: A process for preparing a compound I ##STR1## with A=t-butyl, aryl andR=alkyl, alkenyl, alkynyl, alkenynyl, cycloalkyl(alkyl), aryl, arylalkyl, alkyl-S-(-O)-arylby reacting a compound III ##STR2## with a compound IV ##STR3## under the conditions of a phase-transfer reaction, is described. The process gives excellent yields and is not associated with the unpleasant odor of mercaptans.Type: GrantFiled: December 21, 1990Date of Patent: February 23, 1993Assignee: Hoechst AktiengesellschaftInventors: Gerhard Burdinski, Reinhard Kirsch, Hariolf Kottmann
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Patent number: 5086060Abstract: The effects of acne and psoriasis are relived by applying either topically or by oral adminstration, a compound having the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from the group consisting of H, Cl, straight or branched alkyl of 1 to 10 carbon atoms, NO.sub.2, COOR.sub.6, CN, OR.sub.6, NR.sub.6 R.sub.7, NR.sub.6 C(.dbd.S)NR.sub.7 R.sub.8, NF.sub.6 COR.sub.7, SO.sub.2 NR.sub.6 R.sub.7, CH(CH.sub.3)COOH, CONR.sub.6 R.sub.7, COR.sub.6, OCONR.sub.6 R.sub.7, NR.sub.6 COONR.sub.7, R.sub.9 OR.sub.6, NR.sub.6 SO.sub.2 R.sub.7, Si(CH.sub.3).sub.3, and NR.sub.6 CONR.sub.7 R.sub.8,R.sub.3 together with R.sub.4 forms a benzo ring or taken together with R.sub.2 forms a benzo or tetrahydrobenzo ring or together with R.sub.2 and R.sub.1 forms a: ##STR2## moiety or together with R.sub.2 forms a ##STR3## moiety or R.sub.2 together with R.sub.1 forms a benzo ring or R.sub.2 together with R.sub.3 forms a ##STR4## moiety, or R.sub.Type: GrantFiled: July 16, 1990Date of Patent: February 4, 1992Assignee: Eastman Kodak CompanyInventors: Neil F. Haley, Xina Nair, Gerard J. Gendimenico, F. Christopher Zusi, R. Thomas Swann
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Patent number: 5055582Abstract: This invention relates to a process for preparing useful thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)thioxomethyl]hydrazono]ethyl]-1.alpha. ,4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha.,7a.alpha.-4.alpha.,7.alpha.-meth ano-2H-inden-2-ones.Type: GrantFiled: December 13, 1988Date of Patent: October 8, 1991Assignee: National Research Development CorporationInventors: Robert B. Garland, Masateru Miyano
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Patent number: 4873346Abstract: The present invention provides certain novel substituted benzothiazoles, benzimidazoles and benzoxazoles which are useful as inhibitors of leukotriene biosynthesis and/or as inhibitors of the action of lipoxygenase and/or as inhibitors of mucus secretion in mammalian metabolism. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.Type: GrantFiled: September 20, 1985Date of Patent: October 10, 1989Assignee: The Upjohn CompanyInventor: David J. Anderson
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Patent number: 4824472Abstract: Novel herbicidal 1-cyclyl or polycyclyl substituted 1H-imidazole-5-carboxylic acid derivatives, compositions containing these compounds as active ingredients, and a method for controlling weeds, preferably selectively in crops of useful plants. Processes for making these novel compounds.Type: GrantFiled: December 23, 1987Date of Patent: April 25, 1989Assignee: Janssen Pharmaceutica N.V.Inventors: Guy R. E. Van Lommen, Victor Sipido, Wim G. Verschueren, William R. Lutz
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Patent number: 4631331Abstract: 2-(3H)-benzoxazolone and certain other benzo-N-heterocycles, as such or as their adduction products with epoxides, may be employed as organo-soluble, latent phenolic curing agents for epoxy resins. The phenolic hydroxyls are provided by rearrangement of the adduction products. Excellent shelf lives, pot lives, gel times and physical properties result.Type: GrantFiled: August 9, 1985Date of Patent: December 23, 1986Assignee: The Dow Chemical CompanyInventor: Theodore L. Parker
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Patent number: 4614804Abstract: Dyes of the formula ##STR1## where A and B are H and/or ##STR2## Y is unsubstituted or substituted phenyl, ##STR3## or unsubstituted or substituted benzothiazolyl or benzoxazolyl and R is unsubstituted or substituted alkyl, unsubstituted or substituted phenyl, or alkoxy, alkoxyalkoxy, phenalkyl or alkoxycarboalkyl, are suitable for dyeing and printing cellulose swollen with water-miscible swelling agents and cellulose-containing fiber material.Type: GrantFiled: September 14, 1983Date of Patent: September 30, 1986Assignee: BASF AktiengesellschaftInventors: Gerhard Epple, Reinhold Krallmann, Wolf-Dieter Kermer, Hans Weber
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Patent number: 4585574Abstract: Anthraquinone dyestuffs of the formula ##STR1## in which R.sub.1 and R.sub.2 denote hydrogen, alkyl, cycloalkyl, aryl or aralkyl, and the said hydrocarbon radicals can be substituted, andQ denotes an aryl radical or heterocyclic radical or an --OR', --SR', --CH.dbd.N--R', ##STR2## --CHO or --SO.sub.2 --O--R' radical, whereinR' represents an aryl, aralkyl or heterocyclic radical, and the radicals mentioned for R' can be substituted,processes for their preparation, and liquid-crystalline materials containing anthraquinone dyestuffs.Type: GrantFiled: November 25, 1981Date of Patent: April 29, 1986Assignee: Bayer AktiengesellschaftInventors: Martin Blunck, Uwer Claussen, Rutger Neeff
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Patent number: 4428953Abstract: Novel pleuromutilin derivatives of formula I, ##STR1## in which R.sub.1 is ethyl or vinyl,m is 0 or 1, andR.sub.2 is a heterocyclic radical, in which a 5- or 6-membered, unsaturated or saturated heterocyclic ring containing one or more hetero atoms selected from oxygen, sulphur and nitrogen, is attached to the --S(CH.sub.2).sub.m --group,provided that when m is 0, R.sub.2 is other than pyridyl,their production and use as antimicrobial agents are described.Type: GrantFiled: March 8, 1982Date of Patent: January 31, 1984Assignee: Sandoz, Ltd.Inventors: Heinz Berner, Friederike Turnowsky, Georg Laber, Johannes Hildebrandt
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Patent number: 4256896Abstract: A naphtholactam dyestuff of the general formula (1) ##STR1## in which R represents C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkenyl, C.sub.6 -C.sub.9 -cycloalkyl, C.sub.6 -C.sub.9 -aralkyl, aryl or, preferably, hydrogen, X represents --COOH, --COO.sup..crclbar. cation.sup..sym., a modified carboxyl group, the radical --SO.sub.2 --T or a heterocyclic radical, T denoting alkyl, alkenyl or, preferably, aryl, M represents hydrogen or a cation, Y represents a free or modified carboxyl group, Z is C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, Cl, Br, NO.sub.2, phenyl sulphonyl C.sub.1 -C.sub.4 -alkyl-S, C.sub.1 -C.sub.4 -alkyl sulphonyl, cyano, CONH.sub.2, CONH-C.sub.1 -C.sub.4 -alkyl, and CON(C.sub.1 -C.sub.4 -alkyl).sub.2, n represents 0, 1 or 2, A represents a heterocyclic radical or --CN and B and C can carry further non-ionic substituents.The new dyestuffs give brilliant yellow and red shades on polyester and polyamide fibers.Type: GrantFiled: September 29, 1978Date of Patent: March 17, 1981Assignee: Ciba-Geigy AktiengesellschaftInventors: Hansrudolf Schwander, Christian Zickendraht