Abstract: A slurry distributor includes a feed conduit and a distribution conduit in fluid communication therewith. The feed conduit includes an entry segment with a feed inlet and a feed entry outlet in fluid communication therewith and extending along a first feed flow axis. The feed conduit includes a shaped duct having a bulb portion in fluid communication with the feed entry outlet. The feed conduit includes a transition segment in fluid communication with the bulb portion and extending along a second feed flow axis in non-parallel relationship with the first feed flow axis. The bulb portion has an area of expansion with a cross-sectional flow area that is greater than a cross-sectional flow area of an adjacent area upstream from the area of expansion. The shaped duct has a convex interior surface in confronting relationship with the feed entry outlet of the entry segment.

Abstract: A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Abstract: A compound having the general structure shown in Formula I: or pharmaceutically acceptable salt and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Abstract: An improved process for the preparation of 2-mercaptobenzothiazole by reacting aniline, nitrobenzene, and carbon disulfide is disclosed wherein the improvement comprises employing a reaction temperature profile comprising the steps of: (A) heating the reactants to at least one temperature less than or equal to about 150° C.; (B) then heating the reactants to a temperature in the range of from about 150° C. to about 170° C.; and (C) then heating the reactants to a temperature in the range of from about 220° C. to about 275° C.

Abstract: In a process for the preparation of 2-mercaptobenzothiazole from aniline, sulfur and carbon disulfide under pressure and for separation of the 2-mercaptobenzothiazole from the crude reaction product by cooling and recycling the desirable intermediates and by-products into the reactor together with aniline, sulfur and carbon disulfide, the reaction is carried out using a residence time in the reactor of at least one hour to a time before the 2-mercaptobenzothiazole product thus-formed begins to decompose into undesirable intermediate products. A maximum hydrogen sulfide pressure is maintained on quenching to a temperature ranging between 220 and 280.degree. C. by mixing the crude reaction product with carbon disulfide at a temperature sufficient to obtain a homogeneous quenched mixture. The hydrogen sulfide is removed completely only after crystallization of the 2-mercaptobenzothiazole.

Abstract: Tar-like residues from the preparation of 2-mercaptobenzothiazole can be used by heating them at temperatures above 200.degree. C. for at least 1 hour and separating off the aniline and benzothiazole thereby formed.

Abstract: A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H.sub.2 -antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.

Abstract: A process for the purification of crude 2-mercaptobenzothiazole, prepared by reacting aniline, carbon disulfide and sulfur at elevated temperature and pressure is described. The process comprises the reaction of crude 2-mercaptobenzothiazole with 5-20%, preferably 10-12%, molar excess aqueous alkali metal hydroxide having a concentration of 3 to 20% by weight alkali metal hydroxide at 70.degree. to 90.degree. C. for 0.5-4 hours, with vigorous agitation, followed by filtration of the insoluble impurities and acidification of the filtrate with a non-oxidizing mineral acid, such as hydrochloric and sulfuric acids. The precipitated, filtered product is washed with water and collected in 98-100% yield and 95-98.5% purity.