The Polycyclo Ring System Contains Nitrogen As The Only Ring Hetero Atom Patents (Class 548/364.7)
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Patent number: 6933312Abstract: This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4, n W, X and Y are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).Type: GrantFiled: September 23, 2003Date of Patent: August 23, 2005Assignee: Agouron Pharmaceuticals, Inc.Inventors: David A. Price, Matthew D. Selby, Paul A. Stupple
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Patent number: 6933295Abstract: The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or treating diseases. The compounds are factor Xa inhibitors.Type: GrantFiled: July 3, 2002Date of Patent: August 23, 2005Assignee: Bayer AktiengesellschaftInventors: Alexander Straub, Thomas Lampe, Jens Pohlmann, Susanne Röhrig, Stephan Jordan, Elisabeth Perzborn, Karl-Heinz Schlemmer
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Patent number: 6916798Abstract: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.Type: GrantFiled: August 2, 2002Date of Patent: July 12, 2005Assignee: Vertex Pharmaceuticals IncorporatedInventors: Jeremy Green, Michael J. Arnost, Albert Pierce
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Patent number: 6894173Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.Type: GrantFiled: February 10, 2003Date of Patent: May 17, 2005Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Lin-Hua Zhang, Lei Zhu
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Patent number: 6835513Abstract: Improved organophotoreceptors have: (a) a charge transport compound having the formula: where R1 is hydrogen, a branched or linear alkyl group, a branched or linear unsaturated hydrocarbon group, an ether group, or an aryl group; and R2 and R3 independently have a structure of: in which Ar is selected form the group consisting of; R4 is a hydrogen, or an aromatic group; (b) a charge generating compound; and (c) an electrically conductive substrate.Type: GrantFiled: March 6, 2003Date of Patent: December 28, 2004Assignee: Samsung Electronic Co., Ltd.Inventors: Nusrallah Jubran, Zbigniew Tokarski, Kam W. Law
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Patent number: 6831075Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.Type: GrantFiled: August 22, 2002Date of Patent: December 14, 2004Assignee: Cephalon, Inc.Inventors: Jasbir Singh, Rabindranath Tripathy
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Patent number: 6831039Abstract: The invention relates to 3-(heterocyclyl)-substituted benzoylpyrazois of formula (I), wherein the variables have the following meanings: X is O, NH or N-alkyl; R1 is alkyl; R2, R3, R4, R5 are hydrogen, alkyl or alkyl halide; R6 is halogen, nitro, alkyl halide, alkoxy, halogenalkoxy, alkylthio, halogenalkylthio, alkylsulfonyl or halogenalkylsulfonyl; R7 is hydroxy, alkoxy, alkenyloxy, alkylsulfonyloxy, alkylcarboyloxy, alkylthiocarbonyloxy, phenylsulfonyloxy or phenylcarbonyloxy, and the phenyl radical can be substituted; R8, R9 are alkyl; R10 is hydrogen or alkyl; and R11 is hydrogen or alkyl; and to their agriculturally useable salts. The invention also relates to intermediate products and methods for producing the inventive compounds and to the use of these compounds or products containing them for combating undesirable plants.Type: GrantFiled: May 21, 2001Date of Patent: December 14, 2004Assignee: BASF AktiengesellschaftInventors: Ulf Neidlein, Norbert Götz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Klaus Langemann, Guido Mayer, Ulf Misslitz, Matthias Witschel, Martina Otten, Karl-Otto Westphalen, Helmut Walter
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Publication number: 20040242559Abstract: The invention relates to compounds of formula (I): 1Type: ApplicationFiled: April 23, 2004Publication date: December 2, 2004Applicant: Aventis Pharma S.A.Inventors: Antonio Ugolini, Herve Bouchard
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Publication number: 20040220170Abstract: Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.Type: ApplicationFiled: May 1, 2003Publication date: November 4, 2004Inventors: Robert N. Atkinson, Irene Drizin, Robert J. Gregg, Michael F. Gross, Michael E. Kort, Lei Shi
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Publication number: 20040209935Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1Type: ApplicationFiled: May 3, 2004Publication date: October 21, 2004Inventors: Michael Robin Hale, James Walter Janetka, Francois Maltais, Qing Tang
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Patent number: 6797708Abstract: This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.Type: GrantFiled: November 22, 2002Date of Patent: September 28, 2004Assignee: WyethInventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
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Patent number: 6743817Abstract: Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are also disclosed.Type: GrantFiled: September 6, 2001Date of Patent: June 1, 2004Assignee: Neurogen CorporationInventors: George Maynard, LingHong Xie, Stanislaw Rachwal
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Publication number: 20040097497Abstract: The present invention relates to certain 4-heteroaryl-3-heteroarylidenyl-2-indolinones compounds and their physiologically acceptable salts which modulate the activity of protein kinases (“PKs”), in particular CDK2. The compounds of the present invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical composition containing these compounds and methods of preparing these compounds are also described.Type: ApplicationFiled: August 27, 2003Publication date: May 20, 2004Applicant: Sugen, Inc.Inventors: Peng Cho Tang, Chung Chen Wei, Ping Huang, Jingrong Cui
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Publication number: 20040087624Abstract: Compounds of formula (I) 1Type: ApplicationFiled: December 10, 2003Publication date: May 6, 2004Inventors: Gerard Martin Paul Giblin, Stephen Vernon Frye, Susan Roomans
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Publication number: 20040087616Abstract: The invention provides compounds of Formula I: 1Type: ApplicationFiled: July 25, 2003Publication date: May 6, 2004Inventors: David W. Piotrowski, Eric Jon Jacobsen, Brad A. Acker, Daniel Patrick Walker, Donn G. Wishka, Vincent E. Groppi
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Publication number: 20040006088Abstract: 1Type: ApplicationFiled: June 17, 2003Publication date: January 8, 2004Applicant: Pfizer Inc.Inventors: Dennis J. Hoover, Bernard Hulin, William H. Martin, Judith L. Treadway
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Patent number: 6653300Abstract: This invention describes novel pyrazole compounds of formula I′: wherein Q′ is —O—, —C(R6′)2—, 1,2-cyclopropanediyl, 1,2-cyclobutanediyl, or 1,3-cyclopropanediyl, and R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T—R3 or L—Z—R3, or Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.Type: GrantFiled: December 19, 2001Date of Patent: November 25, 2003Assignee: Vertex Pharmaceuticals IncorporatedInventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Jeremy Green, David Kay, Ronald Knegtel, Andrew Miller, Ronald Tomlison, Pan Li
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Publication number: 20030207188Abstract: Improved organophotoreceptors have:Type: ApplicationFiled: March 6, 2003Publication date: November 6, 2003Inventors: Nusrallah Jubran, Zbigniew Tokarski, Kam W. Law
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Patent number: 6635771Abstract: Compounds of the formula in which R, R′, R7-R11, X, n1 and n3 are as defined herein. These compounds are useful as intermediates for preparing pharmaceutical compounds having pharmacological activity as chemical inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes.Type: GrantFiled: November 22, 2002Date of Patent: October 21, 2003Assignee: WyethInventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
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Publication number: 20030176439Abstract: The present invention relates to compounds of the formula I, 1Type: ApplicationFiled: June 26, 2002Publication date: September 18, 2003Applicant: Aventis Pharma Dutschland GmbHInventors: Manfred Schudok, Otmar Klingler, Hans-Peter Nestler, Hans Matter, Herman Schreuder, Hauke Szillat
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Publication number: 20030165640Abstract: The present invention provides filters for an electronic display device comprising a squarylium compound represented by the general formula (I): 1Type: ApplicationFiled: January 22, 2003Publication date: September 4, 2003Applicant: Kyowa Yuka Co., Ltd.Inventors: Ikuo Shimizu, Motoharu Kinugasa, Hiroshi Toyoda, Shiho Yamada
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Publication number: 20030144282Abstract: This invention provides substituted indole compounds of the general formula: 1Type: ApplicationFiled: November 22, 2002Publication date: July 31, 2003Applicant: WyethInventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
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Publication number: 20030130328Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: ApplicationFiled: September 26, 2002Publication date: July 10, 2003Inventors: Steven W. Andrews, Julie A. Wurster
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Publication number: 20030092751Abstract: Disclosed is an anti-cancer compound represented by Structural Formula (I): 1Type: ApplicationFiled: August 29, 2002Publication date: May 15, 2003Applicant: SBR Pharmaceuticals Corp.Inventors: Keizo Koya, Lijun Sun, Mitsunori Ono, Guiqing Liang, David James, Hao Li, Zhi-Qiang Xia
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Patent number: 6559173Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: GrantFiled: September 26, 2002Date of Patent: May 6, 2003Assignee: Allergan, Inc.Inventors: Steven W. Andrews, Julie A. Wurster
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Publication number: 20030073849Abstract: The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof and pharmaceutically acceptable formulations comprising said compounds 1Type: ApplicationFiled: March 5, 2002Publication date: April 17, 2003Inventors: Ronald J. Mattson, Derek John Denhart, Jeffrey A. Deskus, Jonathan L. Ditta, Lawrence R. Marcin, James R. Epperson, John D. Catt, Dalton King, Mendi A. Higgins
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Publication number: 20030069290Abstract: The invention provides compounds of Formula I: compounds of the Formula I: 1Type: ApplicationFiled: August 14, 2002Publication date: April 10, 2003Inventors: Donn G. Wishka, Jason K. Myers, Bruce N. Rogers, Eric Jon Jacobsen, David W. Piotrowski, Jeffrey W. Corbett, Alice L. Bodnar, Vincent E. Groppi,
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Patent number: 6541499Abstract: The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.Type: GrantFiled: January 21, 2000Date of Patent: April 1, 2003Assignee: Eli Lilly and CompanyInventors: Jolie A Bastian, Nickolay Y Chirgadze, Michael L Denney, Matthew J Fisher, Robert J Foglesong, Richard W Harper, Mary G Johnson, Valentine J Klimkowski, Ho-Shen Lin, Michael P Lynch, Jefferson R McCowan, Shawn C Miller, Jeffrey T Mullaney, Michael E Richett, Daniel J Sall, Gerald F Smith, Kumiko Takeuchi, Jennifer M Tinsley, Michael R Wiley, Minsheng Zhang
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Patent number: 6521638Abstract: Compounds of formula (I) wherein R1, R2, A, q are as defined herein, and salts thereof, have affinity for dopamine receptors, in particular the D3 receptor, and thus have potential in the treatment of conditions wherein modulation of the D3 receptor is beneficial, e.g. as antipsychotic agents.Type: GrantFiled: June 8, 2001Date of Patent: February 18, 2003Assignee: SmithKline Beecham p.l.c.Inventors: Christopher Norbert Johnson, Geoffrey Stemp
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Publication number: 20030004344Abstract: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.Type: ApplicationFiled: January 2, 2002Publication date: January 2, 2003Inventors: Patrick Y.S. Lam, Charles G. Clark, Renhau Li, Donald J.P. Pinto
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Patent number: 6465659Abstract: Reaction of pyrazolones and methyleneindolines with orthoformic esters is an advantageous one-step process for preparing asymmetrical methine dyes.Type: GrantFiled: March 5, 2002Date of Patent: October 15, 2002Assignee: Bayer AktiengesellschaftInventors: Josef-Walter Stawitz, Karl-Heinz Reinhardt, Christoph Thiebes
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Patent number: 6462069Abstract: Amino-pyrazole compounds that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the activity cyclin-dependent kinases, thereby modulating and/or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.Type: GrantFiled: April 17, 2001Date of Patent: October 8, 2002Assignee: Agouron Pharmaceuticals, Inc.Inventors: Siegfried Heinz Reich, Michael B. Wallace
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Patent number: 6455525Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.Type: GrantFiled: October 31, 2000Date of Patent: September 24, 2002Assignee: Cephalon, Inc.Inventors: Jasbir Singh, Rabindranath Tripathy
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Publication number: 20020128489Abstract: Reaction of pyrazolones and methyleneindolines with orthoformic esters is an advantageous one-step process for preparing asymmetrical methine dyes.Type: ApplicationFiled: March 5, 2002Publication date: September 12, 2002Inventors: Josef-Walter Stawitz, Karl-Heinz Reinhardt, Christoph Thiebes
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Patent number: 6429205Abstract: This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.Type: GrantFiled: July 13, 2000Date of Patent: August 6, 2002Assignee: Bristol-Meyers Squibb Pharma CompanyInventors: Irina C. Jacobson, Mimi L. Quan
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Publication number: 20020103381Abstract: The present invention provides a method for the synthesis of compounds of Formula I: 1Type: ApplicationFiled: November 30, 2000Publication date: August 1, 2002Inventor: Armen M. Boldi
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Patent number: 6417189Abstract: The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.Type: GrantFiled: April 17, 2000Date of Patent: July 9, 2002Assignee: GPI NIL Holdings, Inc.Inventors: Yong-Qian Wu, Wei Huang, Gregory S. Hamilton
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Patent number: 6410533Abstract: The present invention provides compounds having useful antibacterial activity and pharmaceutical compositions comprising one or more of these compounds. The invention further relates to a method of treating a bacterial infection in a patient, comprising administering to the patient an effective mount of one or more of the antibacterial compounds of the invention.Type: GrantFiled: February 10, 2000Date of Patent: June 25, 2002Assignee: Genzyme CorporationInventors: Bradford H. Hirth, Andrew Janjigian, Fred Vinick
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Patent number: 6376519Abstract: Compounds of the formula wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula II: wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.Type: GrantFiled: June 16, 2000Date of Patent: April 23, 2002Assignee: Temple University-of the Commonwealth of Higher EducationInventors: E. Premkumar Reddy, M. V. Ramana Reddy
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Publication number: 20020045654Abstract: This invention provides a compound of the formula: 1Type: ApplicationFiled: April 24, 2001Publication date: April 18, 2002Inventors: Kazuo Ando, Tomoki Kato, Akiyoshi Kawai, Tomomi Nonomura
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Publication number: 20020038028Abstract: Compounds of the formula 1Type: ApplicationFiled: November 21, 2001Publication date: March 28, 2002Inventors: Daniel Yohannes, Mark W. Bundesmann
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Publication number: 20020035262Abstract: Compounds of the formula 1Type: ApplicationFiled: November 21, 2001Publication date: March 21, 2002Inventors: Daniel Yohannes, Mark W. Bundesmann
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Patent number: 6335357Abstract: A 1-aryl-3-cyano-5-(het)arylalkylaminopyrazole derivative represented by the general formula (1): process of making, intermediate thereof and pesticide therewith.Type: GrantFiled: October 7, 1999Date of Patent: January 1, 2002Assignee: Mitsubishi Chemical CorporationInventors: Shuko Okui, Nobuo Kyomura, Toshiki Fukuchi, Ken Tanaka
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Patent number: 6329531Abstract: The invention relates to compounds of formula (I): Fm(—A1)(—Bn)(—Wo) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600-1200 nm; A is a &bgr;-amyloid plaque binding biomolecule; B is a &bgr;-amyloid plaque binding colorant; and W is a &bgr;-amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo an din vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a constrasting agent in fluoresecence and transillumination diagnosis in the NIR range. Diagnostic agents containing said componenets are also disclosed.Type: GrantFiled: November 18, 1999Date of Patent: December 11, 2001Assignee: Schering AGInventors: Jonathan Turner, Thomas Dyrks, Wolfhard Semmler, Kai Licha, Bjorn Riefke
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Patent number: 6281356Abstract: Disclosed are substituted pyrroles having the formula These compounds and their pharmaceutically acceptable salts are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds.Type: GrantFiled: December 15, 2000Date of Patent: August 28, 2001Assignee: Hoffmann-La Roche Inc.Inventors: Nader Fotouhi, Norman Kong, Allen John Lovey
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Patent number: 6277847Abstract: This invention relates to herbicidal compounds of formula (I), methods of making such herbicidal compounds and methods of using such herbicidal compounds. It has been found that compounds of formula (I) are useful as pre-emergent and post-emergent herbicides. Formula (I) is as follows: where Q, X, Y, n, and R are as described herein. This invention is also directed to intermediates used in the preparation of such herbicidal compounds.Type: GrantFiled: March 30, 2000Date of Patent: August 21, 2001Assignee: FMC CorporationInventors: George Theodoridis, Scott D. Crawford
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Patent number: 6242422Abstract: This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.Type: GrantFiled: October 22, 1998Date of Patent: June 5, 2001Assignee: Idun Pharmacueticals, Inc.Inventors: Donald S. Karanewsky, Vincent J. Kalish, Edward D. Robinson, Brett R. Ullman
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Patent number: 6218418Abstract: Compounds which are 3-amino-pyrazole derivatives represented by formula (I): where R is a C3-C6 cycloalkyl group, which may optionally be substituted by a straight or branched C1-C6 alkyl group, and R1 is a straight or branched C1-C6 alkyl group or a C2-C4 alkenyl, cycloalkyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl and arylalkenyl, which may be optionally substituted; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.Type: GrantFiled: September 22, 2000Date of Patent: April 17, 2001Assignees: Pharmacia & Upjohn S.p.A, Pharmacia & Upjohn Co.Inventors: Paolo Pevarello, Paolo Orsini, Gabriella Traquandi, Mario Varasi, Edward L. Fritzen, Martha A. Warpehoski, Betsy S. Pierce, Maria Gabriella Brasca
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Patent number: 6207829Abstract: A process is provided for the preparation of a compound of formulae (IA) (sidenafil) and (IB) comprising reacting a compound of formula (IIA) and (IIB) respectively in the presence of —OR, wherein R in the case of formation of compound (IA) is CH2CH3 and R in the case of formation of compound (IB) is CH2CH2CH3, where X is a leaving group:Type: GrantFiled: October 8, 1999Date of Patent: March 27, 2001Assignee: Pfizer Inc.Inventors: Peter James Dunn, Philip Charles Levett
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Patent number: 6187929Abstract: A dye represented by the following formula (1); Formula (1) wherein A represents an acidic nucleus, L1, L2 and L3 represent a methine group, n represents 0, 1 or 2, Z represents a nonmetalic atom group necessary to form a heterocyclic group by bonding with a nitrogen atom included in the above formula (1), Y represents a substituent represented by the following formula (2) or a heterocyclic group; Formula (2) wherein R1 and R2 represent an alkyl group, and R1 and R2 may form a ring by bonding with each other, R3 represents a hydrogen atom or an electron withdrawing group: said dye represented by the above formula (1) has at least one carboxy group or one alkylsulfonamide group in an aromatic ring portion of its molecular structure.Type: GrantFiled: June 14, 1999Date of Patent: February 13, 2001Assignee: Konica CorporationInventors: Mitsuhiro Fukuda, Motoaki Sugino, Akira Onishi