With Preservative Or Stabilizer Patents (Class 549/2)
  • Publication number: 20120322845
    Abstract: The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.
    Type: Application
    Filed: December 22, 2010
    Publication date: December 20, 2012
    Applicants: Lohmann Therapie-Systeme AG, UCB Pharma GmbH
    Inventors: Hans-Michael Wolff, Christoph Arth, Luc Quere, Walter Müller
  • Publication number: 20110102973
    Abstract: The present invention relates to a stabilised monomer composition comprising at least 50 wt.-%, based on the total weight of the stabilised monomer composition, of a thiophene derivative monomer having the general formula (I) in which R1 and R2 stand, independently of one another, for hydrogen, for an optionally substituted C1-C20-alkyl group or C1-C20-oxyalkyl group, optionally interrupted by 1 to 5 oxygen atoms and/or sulfur atoms, or jointly for an optionally substituted C1-C20-dioxyalkylene group or C6-C20-dioxyarylene group, and 0.001 to 10 wt.-%, based on the total weight of the stabilised monomer composition, of a stabiliser. The present invention also relates to a method for the manufacture of a capacitor, a capacitor obtained by this method, the use of a stabilised monomer composition and to the use of a stabiliser.
    Type: Application
    Filed: September 30, 2010
    Publication date: May 5, 2011
    Applicant: H.C. Starck Clevios GmbH
    Inventors: Knud Reuter, Klaus Wussow, Udo Merker, Andreas Elschner
  • Patent number: 7737269
    Abstract: The invention relates to a process for the preparation of a cyclodextrin/alpha-lipoic acid complex, wherein in a first step, an alpha-lipoic acid and a cyclodextrin are dissolved in an aqueous alkaline solution having a pH above pH 7, and in a second step an acid is added to lower the pH of the solution to a pH below pH 7.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: June 15, 2010
    Assignee: Wacker-Chemie GmbH
    Inventors: Helmut Reuscher, Mark Bauer
  • Patent number: 7241903
    Abstract: A metallocene compound of formula (I): wherein M is zirconium, titanium and hafnium; X is a hydrogen atom, a halogen atom or a hydrocarbon radical; R1 is a linear C1-C20-alkyl radical; R2 is a hydrogen atom or hydrocarbon R3, R4, R5, R6, R7, and R8, are hydrogen atoms or hydrocarbon radicals, A is a sulphur (S) atom or an oxygen (O) atom; Q is a radical of formula (II), (III) or (IV) being bonded to the indenyl at the position indicated by the symbol *; (II), (III), (IV) wherein T1 is a sulphur atom, an oxygen (O) atom or a NR; R9, R10 and R11 are hydrogen atoms or hydrocarbon radicals; T2, T3, T4, T5, and T6 are carbon atoms (C) or nitrogen atoms (N); m1, m2, m3, m4 and m5 are 0 or 1; R12, R13, R14, R15 and R16 are hydrogen atoms or hydrocarbon radicals with the provisos that at least one of R12, R13, R14, R15 and R16 is different from hydrogen atoms, and that no more than two of T2, T3, T4, T5 and T6 are nitrogen atoms.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: July 10, 2007
    Assignee: Basell Polyolefine GmbH
    Inventors: Cornelia Fritze, Luigi Resconi, Jörg Schulte, Simona Guidotti
  • Patent number: 6911551
    Abstract: The present invention relates to substituted boron or aluminum spiro compounds and their use in the electronic industry. The compounds of the invention are used as electron transport material, hole blocking material and/or as host material in organic electroluminescence and/or phosphorescence devices, as electron transport material in photocopiers, as electron acceptor or electron transport material in solar cells, as charge transport material in organic ICs (circuits) and in organic solid-state lasers or organic photodetectors.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: June 28, 2005
    Assignee: Covion Organic Semiconductors GmbH
    Inventors: Philipp Stössel, Hubert Spreitzer, Heinrich Becker, Jacqueline Drott
  • Patent number: 6150536
    Abstract: The present invention relates to an organic-inorganic hybrid material comprising an organic component and an inorganic component. The organic component comprises a dye that fluoresces in the visible range. In addition, an optically inert component may replace a portion of the organic dye component to increase fluorescence.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: November 21, 2000
    Assignee: International Business Machines Corporation
    Inventors: Konstantinos Chondroudis, David Brian Mitzi
  • Patent number: 6018056
    Abstract: The instant invention provides processes for preparing compounds of formula IV, V, and IX, having the structures provided hereinbelow: ##STR1## These compounds are useful intermediates in the further preparation of benzo[b] thiophenes.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: January 25, 2000
    Assignee: Eli Lilly and Company
    Inventors: Christopher Randall Schmid, Jerry Wayne Misner
  • Patent number: 5824808
    Abstract: A cyclic phenol sulfide represented by the following formula (1) is described: ##STR1## wherein X represents a hydrogen atom, a hydrocarbon group, or an acyl group; Y.sub.1 represents a hydrogen atom, a hydrocarbon group, a halogenated hydrocarbon group, --COR.sup.1, --OR.sup.2, --COOR.sup.3, --CN, --CONH.sub.2, --NO.sub.2, --NR.sup.4 R.sup.5, a halogen atom, --SO.sub.4 R.sup.6, or --SO.sub.3 R.sup.7, in which R.sup.11, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 each represents a hydrogen atom or a hydrocarbon group; n is an integer of 3 or more; and m is an integer of 1 to 7, provided that the plural m's of the S.sub.m 's are the same or different; the plural X's are the same or different; and the plural Y.sub.1 's are the same or different. A process for producing the cyclic phenol sulfide is also described.
    Type: Grant
    Filed: March 11, 1996
    Date of Patent: October 20, 1998
    Assignees: Cosmo Research Institute, Cosmo Oil Co., Ltd.
    Inventors: Takashi Hori, Hitoshi Kumagai, Mitsuharu Hasegawa, Yoko Sato, Hiroshi Munakata, Yoshihiro Sugawa
  • Patent number: 5723407
    Abstract: A sulfonylsemicarbazide derivative of the general formula (I) is effective as a preservative agent for preserving the freshness of a flower, which can prolong the vase life of the flower petals of cut flowers where the flowers can be enjoyed. ##STR1## wherein R.sup.1 represents a (C.sub.3 -C.sub.4)-alkyl group, a substituted or unsubstituted phenyl group, a pyridyl group, a thio-phenyl group or others, R.sup.2 and R.sup.3 each independently represent a hydrogen atom, a lower alkyl group, an alkoxalyl group, an alkoxyalkyl group, a group of the formula --C(X)--X--R.sup.4 where X means an oxygen atom or a sulfur atom and R.sup.4 means an alkyl group, or other, or R.sup.2 and R.sup.3 may form a heterocyclic ring having 4 to 5 carbon atoms or a group of the formula --N.dbd.CR.sup.5 (R.sup.6), as taken with the --N atom to which R.sup.2 and R.sup.3 are attached.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: March 3, 1998
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Naoki Midou, Kuniomi Matsumoto, Michiaki Iwata, Kunihiko Kurihara, Kunitaka Tachibana
  • Patent number: 5446069
    Abstract: Disclosed are compounds of formula ##STR1## wherein F represents: ##STR2## or a pharmaceutically acceptable salt. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflamation.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: August 29, 1995
    Assignee: Schering Corporation
    Inventors: Neng-Yang Shih, Pietro Mangiaracina, Michael J. Green, Ashit K. Ganguly
  • Patent number: 5225436
    Abstract: Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflammation.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: July 6, 1993
    Assignee: Schering Corporation
    Inventors: Neng-Yang Shih, Pietro Mangiaracina, Michael J. Green, Ashit K. Ganguly
  • Patent number: 5049673
    Abstract: The present invention discloses a new class of calcium specific fluorescent indicator dyes having visible excitation and emission wavelengths. The new fluorescent indicator dyes combine at least one tricyclic chromophore with a tetracarboxylate parent CA.sup.2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of BAPTA to give a rhodamine-like or fluorescein-like fluorophore. Binding of calcium.sup.2+ increases the fluorescence of the new compounds by up to 40-fold. The calcium.sup.2+ dissociation constants are in the range 0.37-2.3 microM, so that the new indicators give better resolution of high [CA.sup.2+ ] levels than were previously obtainable with predecessor compounds such as quin-2 or fluo-2. The visible excitation wavelengths of the new compounds are more convenient for fluorescent microscopy and flow cytometry than the UV required by previous indicators.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: September 17, 1991
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Akwasi Minta
  • Patent number: 4425281
    Abstract: A composition of matter of the formula ##STR1## where M is Cu(I) or Ag(I); R.sup.1 is C.sub.1 -C.sub.6 fluoroalkyl, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.6 heterocycle containing O, S or N or C.sub.6 -C.sub.10 aryl; R.sup.2 is H or C.sub.1 -C.sub.6 alkyl, with the proviso that R.sup.1 and R.sup.2 together with the carbons to which they are attached may be joined together to form a C.sub.6 ring; L is an unsaturated hydrocarbon containing at least one non-aromatic unsaturation; x and y are 1 or 2; and n is from 1 to 8.
    Type: Grant
    Filed: July 13, 1981
    Date of Patent: January 10, 1984
    Assignee: Exxon Research and Engineering Co.
    Inventor: Gerald Doyle