With Preservative Or Stabilizer Patents (Class 549/2)
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Publication number: 20120322845Abstract: The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.Type: ApplicationFiled: December 22, 2010Publication date: December 20, 2012Applicants: Lohmann Therapie-Systeme AG, UCB Pharma GmbHInventors: Hans-Michael Wolff, Christoph Arth, Luc Quere, Walter Müller
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Publication number: 20110102973Abstract: The present invention relates to a stabilised monomer composition comprising at least 50 wt.-%, based on the total weight of the stabilised monomer composition, of a thiophene derivative monomer having the general formula (I) in which R1 and R2 stand, independently of one another, for hydrogen, for an optionally substituted C1-C20-alkyl group or C1-C20-oxyalkyl group, optionally interrupted by 1 to 5 oxygen atoms and/or sulfur atoms, or jointly for an optionally substituted C1-C20-dioxyalkylene group or C6-C20-dioxyarylene group, and 0.001 to 10 wt.-%, based on the total weight of the stabilised monomer composition, of a stabiliser. The present invention also relates to a method for the manufacture of a capacitor, a capacitor obtained by this method, the use of a stabilised monomer composition and to the use of a stabiliser.Type: ApplicationFiled: September 30, 2010Publication date: May 5, 2011Applicant: H.C. Starck Clevios GmbHInventors: Knud Reuter, Klaus Wussow, Udo Merker, Andreas Elschner
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Patent number: 7737269Abstract: The invention relates to a process for the preparation of a cyclodextrin/alpha-lipoic acid complex, wherein in a first step, an alpha-lipoic acid and a cyclodextrin are dissolved in an aqueous alkaline solution having a pH above pH 7, and in a second step an acid is added to lower the pH of the solution to a pH below pH 7.Type: GrantFiled: December 14, 2005Date of Patent: June 15, 2010Assignee: Wacker-Chemie GmbHInventors: Helmut Reuscher, Mark Bauer
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Patent number: 7241903Abstract: A metallocene compound of formula (I): wherein M is zirconium, titanium and hafnium; X is a hydrogen atom, a halogen atom or a hydrocarbon radical; R1 is a linear C1-C20-alkyl radical; R2 is a hydrogen atom or hydrocarbon R3, R4, R5, R6, R7, and R8, are hydrogen atoms or hydrocarbon radicals, A is a sulphur (S) atom or an oxygen (O) atom; Q is a radical of formula (II), (III) or (IV) being bonded to the indenyl at the position indicated by the symbol *; (II), (III), (IV) wherein T1 is a sulphur atom, an oxygen (O) atom or a NR; R9, R10 and R11 are hydrogen atoms or hydrocarbon radicals; T2, T3, T4, T5, and T6 are carbon atoms (C) or nitrogen atoms (N); m1, m2, m3, m4 and m5 are 0 or 1; R12, R13, R14, R15 and R16 are hydrogen atoms or hydrocarbon radicals with the provisos that at least one of R12, R13, R14, R15 and R16 is different from hydrogen atoms, and that no more than two of T2, T3, T4, T5 and T6 are nitrogen atoms.Type: GrantFiled: June 20, 2002Date of Patent: July 10, 2007Assignee: Basell Polyolefine GmbHInventors: Cornelia Fritze, Luigi Resconi, Jörg Schulte, Simona Guidotti
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Patent number: 6911551Abstract: The present invention relates to substituted boron or aluminum spiro compounds and their use in the electronic industry. The compounds of the invention are used as electron transport material, hole blocking material and/or as host material in organic electroluminescence and/or phosphorescence devices, as electron transport material in photocopiers, as electron acceptor or electron transport material in solar cells, as charge transport material in organic ICs (circuits) and in organic solid-state lasers or organic photodetectors.Type: GrantFiled: December 20, 2001Date of Patent: June 28, 2005Assignee: Covion Organic Semiconductors GmbHInventors: Philipp Stössel, Hubert Spreitzer, Heinrich Becker, Jacqueline Drott
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Patent number: 6150536Abstract: The present invention relates to an organic-inorganic hybrid material comprising an organic component and an inorganic component. The organic component comprises a dye that fluoresces in the visible range. In addition, an optically inert component may replace a portion of the organic dye component to increase fluorescence.Type: GrantFiled: July 8, 1999Date of Patent: November 21, 2000Assignee: International Business Machines CorporationInventors: Konstantinos Chondroudis, David Brian Mitzi
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Patent number: 6018056Abstract: The instant invention provides processes for preparing compounds of formula IV, V, and IX, having the structures provided hereinbelow: ##STR1## These compounds are useful intermediates in the further preparation of benzo[b] thiophenes.Type: GrantFiled: April 29, 1998Date of Patent: January 25, 2000Assignee: Eli Lilly and CompanyInventors: Christopher Randall Schmid, Jerry Wayne Misner
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Patent number: 5824808Abstract: A cyclic phenol sulfide represented by the following formula (1) is described: ##STR1## wherein X represents a hydrogen atom, a hydrocarbon group, or an acyl group; Y.sub.1 represents a hydrogen atom, a hydrocarbon group, a halogenated hydrocarbon group, --COR.sup.1, --OR.sup.2, --COOR.sup.3, --CN, --CONH.sub.2, --NO.sub.2, --NR.sup.4 R.sup.5, a halogen atom, --SO.sub.4 R.sup.6, or --SO.sub.3 R.sup.7, in which R.sup.11, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 each represents a hydrogen atom or a hydrocarbon group; n is an integer of 3 or more; and m is an integer of 1 to 7, provided that the plural m's of the S.sub.m 's are the same or different; the plural X's are the same or different; and the plural Y.sub.1 's are the same or different. A process for producing the cyclic phenol sulfide is also described.Type: GrantFiled: March 11, 1996Date of Patent: October 20, 1998Assignees: Cosmo Research Institute, Cosmo Oil Co., Ltd.Inventors: Takashi Hori, Hitoshi Kumagai, Mitsuharu Hasegawa, Yoko Sato, Hiroshi Munakata, Yoshihiro Sugawa
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Patent number: 5723407Abstract: A sulfonylsemicarbazide derivative of the general formula (I) is effective as a preservative agent for preserving the freshness of a flower, which can prolong the vase life of the flower petals of cut flowers where the flowers can be enjoyed. ##STR1## wherein R.sup.1 represents a (C.sub.3 -C.sub.4)-alkyl group, a substituted or unsubstituted phenyl group, a pyridyl group, a thio-phenyl group or others, R.sup.2 and R.sup.3 each independently represent a hydrogen atom, a lower alkyl group, an alkoxalyl group, an alkoxyalkyl group, a group of the formula --C(X)--X--R.sup.4 where X means an oxygen atom or a sulfur atom and R.sup.4 means an alkyl group, or other, or R.sup.2 and R.sup.3 may form a heterocyclic ring having 4 to 5 carbon atoms or a group of the formula --N.dbd.CR.sup.5 (R.sup.6), as taken with the --N atom to which R.sup.2 and R.sup.3 are attached.Type: GrantFiled: February 13, 1996Date of Patent: March 3, 1998Assignee: Meiji Seika Kaisha, Ltd.Inventors: Naoki Midou, Kuniomi Matsumoto, Michiaki Iwata, Kunihiko Kurihara, Kunitaka Tachibana
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Patent number: 5446069Abstract: Disclosed are compounds of formula ##STR1## wherein F represents: ##STR2## or a pharmaceutically acceptable salt. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflamation.Type: GrantFiled: March 29, 1993Date of Patent: August 29, 1995Assignee: Schering CorporationInventors: Neng-Yang Shih, Pietro Mangiaracina, Michael J. Green, Ashit K. Ganguly
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Patent number: 5225436Abstract: Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflammation.Type: GrantFiled: October 15, 1991Date of Patent: July 6, 1993Assignee: Schering CorporationInventors: Neng-Yang Shih, Pietro Mangiaracina, Michael J. Green, Ashit K. Ganguly
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Patent number: 5049673Abstract: The present invention discloses a new class of calcium specific fluorescent indicator dyes having visible excitation and emission wavelengths. The new fluorescent indicator dyes combine at least one tricyclic chromophore with a tetracarboxylate parent CA.sup.2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of BAPTA to give a rhodamine-like or fluorescein-like fluorophore. Binding of calcium.sup.2+ increases the fluorescence of the new compounds by up to 40-fold. The calcium.sup.2+ dissociation constants are in the range 0.37-2.3 microM, so that the new indicators give better resolution of high [CA.sup.2+ ] levels than were previously obtainable with predecessor compounds such as quin-2 or fluo-2. The visible excitation wavelengths of the new compounds are more convenient for fluorescent microscopy and flow cytometry than the UV required by previous indicators.Type: GrantFiled: October 30, 1987Date of Patent: September 17, 1991Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Akwasi Minta
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Patent number: 4425281Abstract: A composition of matter of the formula ##STR1## where M is Cu(I) or Ag(I); R.sup.1 is C.sub.1 -C.sub.6 fluoroalkyl, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.6 heterocycle containing O, S or N or C.sub.6 -C.sub.10 aryl; R.sup.2 is H or C.sub.1 -C.sub.6 alkyl, with the proviso that R.sup.1 and R.sup.2 together with the carbons to which they are attached may be joined together to form a C.sub.6 ring; L is an unsaturated hydrocarbon containing at least one non-aromatic unsaturation; x and y are 1 or 2; and n is from 1 to 8.Type: GrantFiled: July 13, 1981Date of Patent: January 10, 1984Assignee: Exxon Research and Engineering Co.Inventor: Gerald Doyle