Abstract: The person invention relates to a method for the electro-decarboxylation of at least one diene with carbon dioxide CO2 in the presence of hydrogen H2, forming at least one unsaturated dicarboxylic acid, wherein the reaction is carried out in a reactor comprising at least one cathode as the working electrode for the cathodic activation of CO2, at least one anode as the counterelectrode for the anodic oxidation of H2, with a volumetric ration of hydrogen H2 to carbon dioxide CO2 between 1:1 and 1:3, a total pressure pg in the reactor between 2 and 4 MPa, particularly preferably between 3 and 4 MPa, and an average current density j between 5 and 15 mA/cm2, particularly preferably between 10 and 12.5 mA/cm2.

Abstract: Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.

Abstract: A curing agent for epoxy resins has N-benzylethane-1,2-diamine and N,N?-dibenzylethane-1,2-diamine in a weight ratio in the range from 65/35 to 95/5. The curing agent is easy to prepare, thins epoxy resins particularly well, and enables low-emission epoxy resin products that have good workability and a long pot-life, cure reliably and surprisingly fast and can be walked on after a short time, in particular even in cold conditions. Coatings of particularly high mechanical grade, with a high surface quality and a minimal tendency to yellowing, can thus be produced. Epoxy resins of this type are particularly suitable for coating floors.

Abstract: A catalyst for catalytic oxidation of furfural to prepare maleic acid is composed of a carbon nitride doped with a potassium salt. A method for preparing the catalyst includes mixing the potassium salt, a precursor of the carbon nitride and a solvent to obtain a mixture, and drying and calcining the mixture to obtain the catalyst. A use of the catalyst in catalytic oxidation of furfural to prepare maleic acid, wherein the maleic acid is prepared by the step of oxidizing furfural in a solvent in the presence of the catalyst. The invention has the advantages that by using the method provided by the invention to prepare maleic acid, the conversion rate of furfural can be 99% or more and the yield of maleic acid can be up to 70.40%.

Abstract: The strength of a proppant or sand control particulate may be improved by coating the proppant to form a composite. The composite has enhanced compressive strength between about 34 to about 130 MPa and minimizes the spelling of fines at closure stresses in excess of 5,000 psi. Conductivity of fractures is further enhanced by forming a pack of the composites in the fracture.

Abstract: A reaction product of the co-dehydration of a sugar alcohol and a reactant polyol having a number average hydroxyl functionality less than 4.0 is disclosed. In some aspects the sugar alcohol comprises mannitol, sorbitol, xylitol, erythritol, or mixtures thereof. In some preferred aspects the sugar alcohol comprises sorbitol. In some aspects the reactant polyol has an average molecular weight of from 40 to 500 Daltons. In some aspects, the reaction product may be suitable for the manufacture of polyisocyanurate foam. In some aspects the reaction product may be mixed with diluent polyols, such as diols, glycols, ethylene glycol, diethylene glycol, dipropylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol and mixtures thereof.

Abstract: Efficient methods for the production of long-chain unsaturated dicarboxylic compounds are disclosed. Unsaturated dicarboxylic compounds may be prepared from a reaction mixture containing unsaturated carboxylic compounds in the presence of one or more catalysts. In addition to the unsaturated dicarboxylic compounds, alkene compounds may also be produced. The alkene compounds may be removed from the reaction mixture under reduced pressure. The method may also use a wiped-film still as a means to remove the alkene compounds from the reaction mixture. Reaction conditions may be monitored and/or controlled through the use of one or more electronic system(s) in communication with a variety of sensors and controllable devices.

Abstract: The invention relates to compounds and use thereof in the diagnosis and/or in treatment of medical disorders. In some embodiments, the compounds may be used for detecting a cancer. The compound may include a di-acid moiety. In some embodiments the di-acid moiety comprises a di-carboxylic acid and in some embodiments the di-acid moiety comprises a di-tetrazole.

Abstract: A self-metathesis process for the production of unsaturated dicarboxylic fatty diacids and/or unsaturated dicarboxylic fatty diesters, wherein unsaturated carboxylic fatty acids and/or esters of unsaturated carboxylic fatty acids are reacted in the presence of at least one defined ruthenium based catalyst compound. A catalyst enhancer compound selected from a sacrificial catalyst or a non-catalyst enhancer may also be used. The process exhibits improved reaction times and/or the catalyst can be used at very low concentrations.

Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.

Abstract: A method for preparing a carboxylic acid, includes the steps of: providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate is selected from the group made of 2,5-furandicarboxylic acid, fumaric acid, adipic acid, itaconic acid, citric acid, glutaric acid, maleic acid, malonic acid, oxalic acid and fatty acids having more than 10 carbon atoms; acidifying the magnesium carboxylate with hydrogen chloride (HCl), thereby obtaining a solution including carboxylic acid and magnesium chloride (MgCl2); optionally a concentration step, wherein the solution including carboxylic acid and MgCl2 is concentrated; and precipitating the carboxylic acid from the solution including the carboxylic acid and MgCl2, thereby obtaining a carboxylic acid precipitate and a MgCl2 solution.

Abstract: Described herein are compounds and methods of catalyzing ethenolysis reactions, optionally on an industrial scale. In certain embodiments, the catalysts bear cyclic alkyl amino carbene (CAAC) ligands with an ortho substituent, such as a methyl substituent, on an N-aryl ring. When used to catalyze ethenolysis reactions, certain such compounds produce a turnover number greater than 50,000.

Abstract: The present invention relates to novel non-aqueous gels of natural oils and their derivatives and provides a novel process for the gelation of natural oils and their derivatives that does not require the addition of gellants or the irreversible heat bodying of the oil. The gels and method of the present invention are applicable to a wide range of natural oils, and the method is easily tailored to provide thermoreversible gels of any desired viscosity. The natural oil based gels of the present invention and the method of their preparation have many advantages over the prior art. The natural oil based gels provided have exemplary properties and find use in a variety of applications.

Abstract: Novel natural oil derived ink vehicles are provided by a two step process that does not require the addition of gelants or the irreversible heat bodying or polymerization of the oil. The gelled natural oil may be used as the vehicle/carrier in the ink formulation or alternatively used as a carrier or dispersant for additives in ink formulations. The gelled ink vehicles disclosed have many advantages over ink vehicles disclosed in the prior art.

Abstract: The present invention provides an oil-soluble deodorant composition that is highly safe, efficienctly eliminates odors of ammonia, amines and the like and is free of an irritant odor and the like. The present invention relates to an oil-soluble deodorant composition containing at least one of a dimer acids and a trimer acids as an active ingredient.

Abstract: Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.

Abstract: The invention relates to radiation curable compositions comprising a liquid 0/s(acyl)phosphine photo initiators of formula (I): wherein each of Ar1, Ar2 and Ar3 is independently a substituted or unsubstituted aryl group. The invention also relates to stabilized forms of liquid bis(acyl)phosphines of formula (I) and radiation curable composition comprising said stabilized photoinitiators. The radiation curable compositions are selected from the group consisting of an optical fiber coating composition and a coating composition capable of radiation cure on concrete and a coating composition capable of radiation cure on metal.

Abstract: A fraction separated from crude crocetin by preparative HPLC, and identified using LC/MS and NMR as crocetinic acid, markedly regressed the proliferation and increased apoptosis in pancreatic cancer cells. Purified crocetinic acid showed more potency than 15 commercial or crude crocetin using proliferation and apoptosis as markers. Purified crocetinic acid also showed significant anti-tumorigenic activity against pancreatic cancer cells in a mouse model of pancreatic cancer. Given crocetinic acid's low toxicity, crocetinic acid could be used as a chemotherapeutic or chemopreventative agent for pancreatic cancer.

Abstract: The disclosure provides anionic Gemini surfactants comprising at least two carbonyl moieties and at least two aliphatic moieties. In some aspects, at least two of the aliphatic moieties comprise at least seven carbon atoms and at least one pair of conjugated carbon-to-carbon double bonds. The anionic Gemini surfactants are polymerizable and may be used to prepare triply periodic multiply continuous lyotropic phase and polymers thereof that substantially retain triply periodic multiply continuous lyotropic phase structure.

Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.

Abstract: The invention relates to a process for preparing chiral octenoic acid derivatives, which constitute important intermediates in the preparation of medicament active ingredients, and also to novel intermediates which are used in the process for preparing the octenoic acid derivatives mentioned.

Abstract: The invention relates to a method for producing ?,?-unsaturated dicarboxylic acids and the corresponding saturated dicarboxylic acids, whereby the corresponding cycloalkene and acrylic acid are reacted with a ruthenium catalyst by way of a metathesis reaction at high substrate concentrations until the reaction takes place in substance, the resulting dicarboxylic acid being precipitated.

Abstract: The invention relates to a method for producing 1,2-dodeca-2,10-diene diacid and 1,12-dodecanoic acid whereby cyclooctene and acrylic acid are reacted with a ruthenium catalyst by way of a metathesis reaction at high substrate concentrations until the reaction takes place in substance, the resulting unsaturated dicarboxylic acid being precipitated and being hydrated in a second reaction step.

Abstract: A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of a metathesis catalyst to form self-/cross-metathesis products comprising: cyclohexadiene; at least one olefin; and one or more acid-, ester-, or salt-functionalized alkene; and reacting cyclohexadiene to produce at least one cycloalkane or cycloalkane derivatives.

Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.

Abstract: The patent application relates to a method of producing a monomer component from a genetically modified polyhydroxyalkanoate (PHA) biomass, wherein the biomass is heated in the presence of a catalyst to release a monomer component from the PHA.

Abstract: The present invention provides processes and intermediates for preparing cinacalcet base and pharmaceutically acceptable salts thereof.

Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.

Abstract: The invention relates to a process for preparing chiral octenoic acid derivatives, which constitute important intermediates in the preparation of medicament active ingredients, and also to novel intermediates which are used in the process for preparing the octenoic acid derivatives mentioned.

Abstract: An improved process for preparing ammonium salts from fumaric or succinic acid, is described. The method consists of neutralizing the corresponding acid carbonate or ammonium bicarbonate at a molar stoichiometric or greater than the stoichiometric ratio of 4-5% in a saturated aqueous solution of the synthesized salt at a temperature not exceeding 40° C., followed by separation of the product and drying at a temperature not exceeding 70° C. After separation of the ammonium salts, the filtrate can be re-used. Isolation of the product is usually carried out by cooling the reaction mixture to a temperature of 15-18C°. The product comes out in almost crystalline form. Saturated aqueous solution of the synthesized salt is formed by the interaction of carbonate or ammonium bicarbonate with the appropriate acid at a temperature not exceeding 40° C. It is possible to obtain cleaner salt concentration weighing more than 99% and not yielding lower than 98%.

Abstract: The invention relates to radiation curable compositions comprising a liquid 0/s(acyl)phosphine photo initiators of formula (Ï): wherein each of Ar1, Ar2 and Ar3 is independently a substituted or unsubstituted aryl group. The invention also relates to stabilized forms of liquid bis(acyl)phosphines of formula (I) and radiation curable composition comprising said stabilized photoinitiators. The radiation curable compositions are selected from the group consisting of an optical fiber coating composition and a coating composition capable of radiation cure on concrete and a coating composition capable of radiation cure on metal.

Abstract: The subject invention provides deuterated rasagiline, its salts and uses.

Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.

Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.

Abstract: A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of a metathesis catalyst to form self-/cross-metathesis products comprising: cyclohexadiene; at least one olefin; and one or more acid-, ester-, or salt-functionalized alkene; and reacting cyclohexadiene to produce at least one cycloalkane or cycloalkane derivatives.

Abstract: Salts and/or co-crystals of (+)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]-phenol or of (?)-3-[2-(dimethylamino)methyl-1-hydroxy-cyclohexyl]phenol, present in crystalline form, with cinnamic acid, C8- to C10-alkane-monocarboxylic acids, C6- to C10-alkanedicarboxylic acids, C15- to C17-alkane-monocarboxylic acids, fumaric acid, tartaric acid, mandelic acid, hippuric acid and/or embonic acid, a process for their production, and the use of such salts and/or co-crystals as medicaments.

Abstract: Compounds represented by the following general formula (1a) or (1b). A complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active beta-substituted carbonyl compound synthesis and catalyst for asymmetric 1, 2 addition reaction being composed of the complex. A method of production of an optically active beta-aryl compound from an alpha, beta-unsaturated compound and an aryl-boronic acid derivative and method of production of an optically active aryl alcohol compound from an aldehyde compound and aryl boronic acid derivatives using the catalyst. A complex comprising a center metal of palladium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for asymmetric allylic substitution reaction being composed of the complex.

Abstract: The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, chiral cis-diacid of formula II, aziridine of formula XI and a monocyclic compound of formula III.

Abstract: A process for the oxidation of alcohol and/or aldehyde groups with a peroxo compound in the presence of a heterogeneous rhenium based catalyst, and a co-catalyst. The process of the invention may, for example, be applied to the manufacture of maleic acid which can be dehydrated to lead to maleic anhydride.

Abstract: The present invention provides crystalline and amorphous salts of O-desmethylvenlafaxine and processes for preparing said salts of O-desmethylvenlafaxine. The present invention further provides pharmaceutical compositions comprising said salts of O-desmethylvenlafaxine.

Abstract: A polyalkenyl succinic anhydride is prepared with low amounts of resinous or chlorinated byproducts in a two-step process whereby a polyalkene is first reacted with an unsaturated organic acid in a thermal ene reaction, followed with exposure to a gaseous halogen in presence of an additional amount of the unsaturated organic acidic reagent. The foregoing process produces a polyisobutenyl succinic anhydride having a high ratio of succinic anhydride functional groups to polyisobutenyl backbone groups. Such a polyisobutenyl succinic anhydride is particular suitable for the production of oil-soluble hydrocarbyl succinimides that have good dispersant properties when added to lubricating oil compositions.

Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.

Abstract: The invention relates to a method for producing 1,2-dodeca-2,10-diene diacid and 1,12-dodecanoic acid whereby cyclooctene and acrylic acid are reacted with a ruthenium catalyst by way of a metathesis reaction at high substrate concentrations until the reaction takes place in substance, the resulting unsaturated dicarboxylic acid being precipitated and being hydrated in a second reaction step.

Abstract: The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fumarate and imaging media comprising hyperpolarised 13C-fumarate for use in said method.

Abstract: The present invention relates to olefin metathesis processes for the manufacture of a compound of the formula (I) which is a novel useful intermediate in the synthesis of pharmaceutically active compounds.

Abstract: Novel compositions comprising anionic-cationic complexes as conditioning agents for use in products that improve the appearance and feel of skin and hair are well known. This invention describes the use of additional cationic surfactant in combination with an anionic-cationic complex made from a fatty alkyl dialkylamine and a “dicarboxylic acid”, preferably a dimer acid. This combination provides exceptional conditioning for hair, improving both wet and dry combing. It also makes very stable oil-in-water emulsions, and adds a slippery feel and lubricity to shaving and skin cleaning products.

Abstract: The present invention provides a disinfectant comprising as an active ingredient maleic acid and/or maleic anhydride.

Abstract: Method of preparation of maleimides by thermal cyclization of maleamic acids in the presence of a catalyst consists in that reaction of a substituted maleic anhydride with a primary amine is performed in an organic solvent in the presence of betaine at a temperature of 100 to 180° C., at a ratio of the primary amine to the substituted maleic anhydride of 0.6:1.6. Maleimides, obtained in this way, are further purified by extraction, and finally, they are crystallized. As a catalyst, there may be also used betaine in a mixture with inorganic and organic acids, or betaine may be deposited on a solid carrier, or possibly, betaine may be deposited on a carrier in combination with inorganic acids.

Abstract: Described are methods of making organic compounds by metathesis chemistry. The methods of the invention are particularly useful for making industrially-important organic compounds beginning with starting compositions derived from renewable feedstocks, such as natural oils. The methods make use of a cross-metathesis step with an olefin compound to produce functionalized alkene intermediates having a pre-determined double bond position. Once isolated, the functionalized alkene intermediate can be self-metathesized or cross-metathesized (e.g., with a second functionalized alkene) to produce the desired organic compound or a precursor thereto. The method may be used to make bifunctional organic compounds, such as diacids, diesters, dicarboxylate salts, acid/esters, acid/amines, acid/alcohols, acid/aldehydes, acid/ketones, acid/halides, acid/nitriles, ester/amines, ester/alcohols, ester/aldehydes, ester/ketones, ester/halides, ester/nitriles, and the like.

Abstract: A compound represented by the general formula below or a salt thereof is a useful intermediate in the production of a [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound that has excellent cell adhesion inhibitory effect and cell invasion inhibitory effect and therefore is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases induced by the adhesion and invasion of leukocytes, such as inflammatory bowel diseases (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R1 and R2 independently represent hydrogen or a protecting group for an amino group, or R1 and R2 bond together to form an optionally substituted pyrrole ring.