Patents Assigned to University of Rochester
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Publication number: 20240043825Abstract: Methods and systems for creating patterns in tissue growth for tissue engineering are disclosed. In one embodiment, a method for arranging biological cells along predetermined patterns using an ultrasound includes: emitting the ultrasound by an ultrasound transducer; transmitting the ultrasound through a holographic lens toward a plurality of cells; and generating a pressure field in the predetermined patterns. The predetermined pattern includes a plurality of mutually parallel transverse planes. The parallel transverse planes are configured to entrap groups of cells of the plurality of cells. The axial pressure gradients within the parallel transverse planes are smaller than a first predetermined threshold. The lateral pressure gradients within the parallel transverse planes are larger than a second predetermined threshold. In response to generating the pressure field, the groups of entrapped cells are aligned within parallel transverse planes.Type: ApplicationFiled: August 3, 2023Publication date: February 8, 2024Applicants: UNIVERSITY OF WASHINGTON, University of RochesterInventors: Michael R. Bailey, Adam D. Maxwell, Mohamed Abdalla Ghanem, Diane Dalecki
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Publication number: 20240029587Abstract: The invention provides systems and methods for improved simulation of surgical procedures, using models of anatomical organs. The models comprise models of internal components present in the anatomical organ. The models of the internal components are registered to the position which the internal component occupies in the anatomical organ, and in some embodiments the models of the anatomical organ can lose simulated physiological fluids during simulated surgery.Type: ApplicationFiled: October 3, 2023Publication date: January 25, 2024Applicant: University of RochesterInventors: Jonathan STONE, Ahmed E. GHAZI
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Publication number: 20240009350Abstract: The present invention relates to enhancing mechanical properties of tissue such as collagenous or collagen-containing or elastin-containing tissue (e.g., tendons, ligaments, and cartilage) and treating related musculoskeletal and non-musculoskeletal conditions or injuries.Type: ApplicationFiled: May 3, 2023Publication date: January 11, 2024Applicant: University of RochesterInventor: Catherine K. Kuo
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Patent number: 11867602Abstract: A device, system and method for the detection and screening of plastic microparticles in a sample is disclosed. A nanoporous silicon nitride membrane is used to entrap plastic microparticles contained in the sample. The sample may be a water sample, an air sample, or other liquid or gas sample. The entrapped plastic microparticles are then heated or otherwise processed on the nanoporous silicon nitride membrane. An imaging system observes the nanoporous silicon nitride membrane with the entrapped plastic microparticles to determine the type and quantity of the various plastic microparticles that are entrapped on the membrane.Type: GrantFiled: January 19, 2022Date of Patent: January 9, 2024Assignee: University of RochesterInventors: Wayne H. Knox, Gregory Madejski, James Lionel McGrath
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Patent number: 11866702Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.Type: GrantFiled: March 27, 2019Date of Patent: January 9, 2024Assignees: University of Rochester, ProQR Therapeutics II B.V.Inventors: Bart Klein, Janne Juha Turunen, Lenka Van Sint Fiet, Pedro Duarte Morais Fernandes Arantes Da Silva, Julien Auguste Germain Boudet, Yi-Tao Yu, Hironori Adachi, Meemanage De Zoysa
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Patent number: 11860100Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments.Type: GrantFiled: January 25, 2019Date of Patent: January 2, 2024Assignee: UNIVERSITY OF ROCHESTERInventors: Stavros G. Demos, Chi Huang
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Publication number: 20230414083Abstract: A surgical visualization and medical imaging device and related computer based imaging methods and systems are disclosed. The surgical devices of the present invention use indocyanine green dye combined with a plastic, and are used in enhanced surgical imaging in applications such as robotically assisted surgeries. A near infrared light source, such as an 805 nm laser, may be used to excite the surgical device so that the device emits 835 nm light. Both the excitation and emission wavelengths penetrate tissue and blood, and provide enhanced imaging of surgical procedures. The resulting fluorescence image allows a user to readily determine relative tissue depth, to identify tissue inhomogeneity, to detect masses or tissue irregularities, to pinpoint anatomical holes, and to visualize tears.Type: ApplicationFiled: September 1, 2023Publication date: December 28, 2023Applicant: University of RochesterInventors: Paula Jaye Doyle, Jay Evan Reeder, Ronald Wesley Wood
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Patent number: 11845143Abstract: A pre-objective two-degree-of-freedom galvanometer scanning system including two galvo mirrors (111,112) with an optical relay (120) between the mirrors (111,112) and a microscope objective (130) with a curved image plane (140) is presented. The second galvo mirror (112) is located in the aperture stop before the objective. The optical system enables scanning in both directions over the full, curved field for creating custom refractive structures across the 6.5 mm optical zone of contact lenses using femtosecond micro-modification.Type: GrantFiled: July 6, 2018Date of Patent: December 19, 2023Assignee: University of RochesterInventors: Daniel R. Brooks, Jonathan D. Ellis
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Publication number: 20230393118Abstract: In some embodiments, the invention provides tissue-on-a-chip and organ-on-a-chip devices with integrated, on-board photonic integrated circuit optical sensors that allow real-time detection of analytes released from cells disposed on either side of a porous, ultrathin membrane within the device. The invention further provides modular devices for studying cells and interactions between and among cell types. The devices and methods using them are useful for, among other thing, modeling the biological and physiological interactions of cells of different tissue types, allowing high-throughput screening of drug candidates, and informing safety and efficacy in a virtual clinical trial.Type: ApplicationFiled: November 8, 2021Publication date: December 7, 2023Applicant: University of RochesterInventors: John S. COGNETTI, Benjamin L. MILLER, Hani A. AWAD, Raquel E. AJALIK
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Publication number: 20230396031Abstract: At least one beam of pump pulses is combined in a nonlinear process with a plurality of monochromatic beams, each containing signal pulses of a unique wavelength. This produces an ensemble of beams of pulses having wavelengths of medium length. Then, all of the pulses in all of the beams in the ensemble are subject to second harmonic generation, optical parametric amplification, sum-frequency generation, or combinations to reduce the wavelengths of those pulses to ultraviolet wavelengths, thereby creating driver pulses. Driver beams made up of those reduced-wavelength driver pulses can then be focused upon a fuel pellet.Type: ApplicationFiled: May 25, 2023Publication date: December 7, 2023Applicant: University of RochesterInventors: Jonathan D. Zuegel, Christophe Dorrer
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Patent number: 11833081Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or ocular tissues is performed to address various types of vision correction, and the laser induced changes to the refractive index avoid ablation and removal of the optical polymer materials while minimizing scattering losses.Type: GrantFiled: May 14, 2019Date of Patent: December 5, 2023Assignees: University of Rochester, Clerio Vision, Inc., Arizona Board of Regents on Behalf of the University of ArizonaInventors: Leonard Zheleznyak, Corey Leeson, Jonathan D. Ellis, Theodore Foos, Sam C. Butler
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Publication number: 20230384595Abstract: A lightguide comprised of a transmission medium having a first curved outer surface and a second curved outer surface and in at least one cross-section of the lightguide. The first curved outer surface and the second curved outer surface are substantially concentric around a point. The transmission medium having a gradient index of refraction that decreases as function of increasing distance from the point, the gradient index extending from the first curved surface to the second curved surface. At least one light extraction element disposed to extract light from the transmission medium and direct the light generally toward the point. Both the lightguide and the gradient index profiles may be spherical or cylindrical.Type: ApplicationFiled: October 14, 2021Publication date: November 30, 2023Applicant: University of RochesterInventors: Nicholas S. Kochan, Tianyi Yang, Greg R. Schmidt
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Publication number: 20230371403Abstract: Superconductive materials and methods of making the same are described, in which the superconductive materials are grown on a crystalline substrate having lattice parameters that impart a strain on the superconductive materials that reduces an applied pressure at which the superconductive materials exhibit superconductivity.Type: ApplicationFiled: July 29, 2021Publication date: November 16, 2023Applicants: University of Rochester, THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA,Inventors: Liyanagamage R. Dias, Ashkan Salamat
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Patent number: 11808774Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: January 25, 2021Date of Patent: November 7, 2023Assignees: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
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Publication number: 20230330116Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistence to the treatment, prevention, and diagnosis of diseases/symptoms induced by multiple myeloma. Embodiments include methods of treating a bone related disease, comprising the steps of: administering to a subject at least one therapeutically effective dose of a compound disclosed herein.Type: ApplicationFiled: March 30, 2023Publication date: October 19, 2023Applicants: Indiana University Research and Technology Corporation, University of Rochester, The United States of America As Represented by the Department of Veterans Affairs Office of GeneralInventors: Teresita M. Bellido, G. David Roodman, Jesus Delgado-Calle, Robert K. Boeckman, Frank H. Ebetino
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Patent number: 11789207Abstract: A device for attaching at least one optical fiber to a chip includes at least one nanowaveguide disposed on a substrate of a chip to be attached to an at least one off-chip fiber respectively. At least one oxide taper mode converter is disposed around a nanowaveguide end and in optical communication with and modally coupled to each of the at least one nanowaveguide respectively, and adapted such that each corresponding fiber of at least one off-chip fiber corresponds to a cleaved fiber end each cleaved fiber end to be fused to each oxide taper mode converter respectively to optically couple and mode match each cleaved fiber end to each of the nanowaveguide ends of each of the at least one nanowaveguide via the oxide taper mode converter by a modal coupling. A method for attaching at least one optical fiber to a chip is also described.Type: GrantFiled: September 10, 2020Date of Patent: October 17, 2023Assignee: University of RochesterInventors: Jaime Cardenas, Juniyali Nauriyal
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Patent number: 11782192Abstract: A GRIN optic having an optical axis (z-direction) and a GRIN profile varying in the x and y-directions, the profile having one or more discontinuities extending in the x-y direction. The discontinuities may form a non-closed shape or have a non-smooth rectilinear shape. The GRIN optic may have plane-parallel surfaces. A method of designing a GRIN optic which includes mapping discretized elements in the light output specification to array elements of a linear GRIN array elements, identifying for each array element, a base refractive index n0, a gradient magnitude ?, and a gradient direction ?G capable of directing a beamlet from the light source to a corresponding location in the light output specification, and constructing a piecewise-continuous freeform GRIN profile of the GRIN optic by integrating the discrete linear GRIN array elements into a continuous refractive index profile.Type: GrantFiled: February 3, 2021Date of Patent: October 10, 2023Assignee: University of RochesterInventors: David H. Lippman, Greg R. Schmidt
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Patent number: 11776428Abstract: The invention provides systems and methods for improved simulation of surgical procedures, using models of anatomical organs. The models comprise models of internal components present in the anatomical organ. The models of the internal components are registered to the position which the internal component occupies in the anatomical organ, and in some embodiments the models of the anatomical organ can lose simulated physiological fluids during simulated surgery.Type: GrantFiled: December 27, 2018Date of Patent: October 3, 2023Assignee: University of RochesterInventors: Jonathan Stone, Ahmed E. Ghazi
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Publication number: 20230301203Abstract: Compositions of matter and methods of identifying and making compositions of matter are disclosed. Some embodiments disclose making and chemically and/or compositionally tuning superconducting hydride materials. Some embodiments disclose an apparatus for making and compositionally tuning superconducting materials. Some embodiments disclose a composition of matter including a solid hydride exhibiting superconductivity at a temperature of at least 150 kelvin at an ambient pressure below 180 gigapascals, or at a temperature of at least 261 kelvin. In one or more embodiments, the superconductor includes a covalent metal hydride having at least three different chemical elements wherein an inter-atomic distance between the hydrogen in the covalent metal hydride is in a range of 1.1-2 angstroms. In yet further examples, the superconductor is formed using molecular exchange and compression of a Van der Waals solid.Type: ApplicationFiled: July 20, 2021Publication date: September 21, 2023Applicants: University of Rochester, THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADAInventors: Liyanagamage R. Dias, Ashkan Salamat
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Publication number: 20230285299Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.Type: ApplicationFiled: April 14, 2023Publication date: September 14, 2023Applicant: UNIVERSITY OF ROCHESTERInventors: John Elfar, Kuang-Ching Tseng, Mark Noble