Abstract: A method is disclosed for determining the percent volume of fat in an organ (advantageously, the liver) of a living subject. Radiation (advantageously shear waves of known frequency and amplitude) is directed into the liver. The speed with which the radiation propagates within the liver, and the attenuation of the amplitude of the radiation caused by the liver, are measured. From these measured quantities, the percent volume of fat in the liver can be determined. The determination can be carried out by calculation, or by using a nomogram.
Abstract: A heat transfer device and method are disclosed. The device includes a working region (i.e., working substance) made from a first superconducting material having a superconducting state and a normal state when magnetized. The first superconducting material has a first energy gap while in the superconducting state. A substrate (i.e., cold reservoir) is connected to the working region at a first tunnel junction. The substrate may be a metallic substrate. A heat sink (i.e., hot reservoir) is connected to the working region at a second tunnel junction. The heat sink is made from a second superconducting material having a second energy gap that is larger than the first energy gap. In a particular example, the heat transfer device includes a metallic substrate is made from Copper, a working region made from Tantalum, a heat sink made from Niobium, and the first and second tunnel junctions are made from Tantalum Oxide.
Type:
Grant
Filed:
October 4, 2019
Date of Patent:
September 20, 2022
Assignees:
University of Rochester, Consiglio Nazionale delle Ricerche—CNR
Inventors:
Andrew N. Jordan, Francesco Giazotto, Sreenath K. Manikandan
Abstract: A method, system and devices to selectively control modal vibrations in an elastic panel with a number of force actuators distributed throughout the surface of the elastic panel to excite/depress the response of one or more vibrational resonant modes included in a prescribed subset. The force actuators are disposed such that prescribed modal excitation/depression may be realized when the actuators are driven by a common source signal.
Type:
Grant
Filed:
October 3, 2019
Date of Patent:
September 6, 2022
Assignee:
THE UNIVERSITY OF ROCHESTER
Inventors:
Michael Charles Heilemann, Mark Frederick Bocko, David Allan Anderson
Abstract: Ultrasound imaging at high spatial resolution that makes use of both magnitude and phase of echoes in an image reconstruction process that applies unique constraints to a fitting of echoes from the object of interest to echoes from an array of known scatterers.
Abstract: The present invention relates to isolated peptides suitable for disrupting an epithelial barrier, transepithelial dmg or vaccine formulations, drug delivery vehicles for delivering these formulations, and methods of using of these formulations for disrupting an epithelial barrier.
Type:
Application
Filed:
June 2, 2020
Publication date:
August 11, 2022
Applicant:
University of Rochester
Inventors:
Benjamin L. Miller, Lisa A. Beck, Matthew G. Brewer
Abstract: An ultrasound study in which the reflected echoes are analyzed to determine a physical characteristic of scatterers within the volume of interest, the acoustic attenuation within the volume of interest, and the echo amplitude. These data are used to diagnose the disease state and the progression of disease.
Abstract: A GRIN optic having an optical axis (z-direction) and a GRIN profile varying in the x and y-directions, the profile having one or more discontinuities extending in the x-y direction. The discontinuities may form a non-closed shape or have a non-smooth rectilinear shape. The GRIN optic may have plane-parallel surfaces. A method of designing a GRIN optic which includes mapping discretized elements in the light output specification to array elements of a linear GRIN array elements, identifying for each array element, a base refractive index n0, a gradient magnitude ?, and a gradient direction ?G capable of directing a beamlet from the light source to a corresponding location in the light output specification, and constructing a piecewise-continuous freeform GRIN profile of the GRIN optic by integrating the discrete linear GRIN array elements into a continuous refractive index profile.
Abstract: Systems and methods for assessing multi-layer structures in which a spectrum array is generated from low coherence interferometry and input into a statistical estimator, which determines the thickness and layer number based on the inputted spectrum and other information, including information about a source intensity noise, Poisson noise, and dark noise associated with the low coherence interferometry.
Type:
Grant
Filed:
April 30, 2019
Date of Patent:
August 2, 2022
Assignees:
University of Rochester, The University of Arizona
Inventors:
Jinxin Huang, Jannick P. Rolland, Eric Clarkson, Matthew Kupinski
Abstract: A device, system and method for the detection and screening of plastic microparticles in a sample is disclosed. A nanoporous silicon nitride membrane is used to entrap plastic microparticles contained in the sample. The sample may be a water sample, an air sample, or other liquid or gas sample. The entrapped plastic microparticles are then heated or otherwise processed on the nanoporous silicon nitride membrane. An imaging system observes the nanoporous silicon nitride membrane with tic entrapped plastic microparticles to determine the type and quantity of the various plastic microparticles that are entrapped on the membrane.
Type:
Application
Filed:
January 19, 2022
Publication date:
July 21, 2022
Applicant:
University of Rochester
Inventors:
Wayne H. Knox, Gregory Madejski, James Lionel McGrath
Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical tissues is performed in combination with corneal lenticular surgery to achieve overall desired vision corrections.
Abstract: A hybrid integrated thermal sensor device includes a magnetic tunnel junction (MTJ) device electrically coupled in series with at least one CMOS transistor and disposed between a voltage rail terminal and a ground terminal. An output terminal is electrically coupled to a drain of the at least one CMOS transistor. The MTJ operates in an anti-parallel state and the output terminal provides a voltage indicative of a temperature of the MTJ device based on an MTJ antiparallel resistance. A distributed sensor network for real-time thermal mapping of an integrated circuit (IC) is also described.
Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or ocular tissues is performed to address various types of vision correction.
Type:
Grant
Filed:
May 14, 2019
Date of Patent:
June 28, 2022
Assignees:
University of Rochester, Clerio Vision, Inc.
Inventors:
Leonard Zheleznyak, Cory Leeson, Jonathan D. Ellis, Theodore Foos, Sam C. Butler
Abstract: An integrated optical device includes a substrate. A waveguide includes a lithium niobate. A TiO2 coating is disposed at least in part over a longitudinal surface of the waveguide as a coated waveguide supported by the substrate. A silicon oxide substantially can cover and surround the waveguide in cross section over a longitudinal direction of said waveguide as an optical cladding. A method for substantially eliminating optical damage in lithium niobate devices is also described.
Abstract: A method to image an in vivo object in an eye includes illuminating an object in the eye by a light source; configuring one or more detectors to receive light from a conjugate plane behind a confocal plane of the object, the conjugate plane acting as a light screen; receiving at the one or more detectors a backscattered light from the light source which has been refracted at least in part by the object before being backscattered from the light screen to provide a detector data; and processing the detector data over a time period by a computer to generate information about the object.
Type:
Grant
Filed:
October 22, 2019
Date of Patent:
May 24, 2022
Assignee:
University of Rochester
Inventors:
Raul Andres Guevara-Torres, Jesse Schallek, Aby Joseph
Abstract: This invention relates to methods to determine vaccine candidate strains that can be used to induce broadly cross-reactive immunity against pathogens, related vaccines, and related methods.
Abstract: The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.
Type:
Grant
Filed:
February 2, 2018
Date of Patent:
March 22, 2022
Assignees:
Georgetown University, University of Rochester
Inventors:
Mark E. Mapstone, Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema