Patents by Inventor Julius F. Remenar

Julius F. Remenar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODRUGS OF NH-ACIDIC COMPOUNDS
    Publication number: 20190284181
    Abstract: The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
    Type: Application
    Filed: June 29, 2018
    Publication date: September 19, 2019
    Inventors: Laura Cook Blumberg, Julius F. Remenar, Orn Almarsson, Tarek A. Zeidan
  • HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS
    Publication number: 20190276406
    Abstract: Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
    Type: Application
    Filed: May 29, 2019
    Publication date: September 12, 2019
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Pharmaceutical Compositions Having Improved Storage Stability
    Publication number: 20190275155
    Abstract: The present invention relates to a pharmaceutical composition that provides long-term stability of a hydrolytically labile antipsychotic agent
    Type: Application
    Filed: May 29, 2019
    Publication date: September 12, 2019
    Inventors: Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver, Michael J. Palmieri, JR., Zhengzheng Pan
  • Pharmaceutical Compositions Comprising Sorbitan Esters
    Publication number: 20190216805
    Abstract: The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
    Type: Application
    Filed: January 15, 2019
    Publication date: July 18, 2019
    Inventors: Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver
  • Heterocyclic compounds for the treatment of neurological and psychological disorders
    Patent number: 10351529
    Abstract: Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: July 16, 2019
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Pharmaceutical compositions having improved storage stability
    Patent number: 10342877
    Abstract: The present invention relates to a pharmaceutical composition that provides long-term stability of a hydrolytically labile antipsychotic agent.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: July 9, 2019
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver, Michael J. Palmieri, Jr., Zhengzheng Pan
  • HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS
    Publication number: 20190084937
    Abstract: Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
    Type: Application
    Filed: September 14, 2018
    Publication date: March 21, 2019
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Pharmaceutical compositions comprising sorbitan esters
    Patent number: 10226458
    Abstract: The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 12, 2019
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver
  • PRODRUGS OF NH-ACIDIC COMPOUNDS
    Publication number: 20190031648
    Abstract: The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
    Type: Application
    Filed: June 29, 2018
    Publication date: January 31, 2019
    Inventors: Laura Cook Blumberg, Julius F. Remenar, Orn Almarsson, Tarek A. Zeidan
  • Heterocyclic compounds for the treatment of neurological and psychological disorders
    Patent number: 10112903
    Abstract: Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: October 30, 2018
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Prodrugs of NH-acidic compounds
    Patent number: 10040787
    Abstract: The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: August 7, 2018
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Laura Cook Blumberg, Julius F. Remenar, Orn Almarsson, Tarek A. Zeidan
  • Heterocyclic compounds for the treatment of neurological and psychological disorders
    Patent number: 10023537
    Abstract: Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: July 17, 2018
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Process for synthesizing oxidized lactam compounds
    Patent number: 10011569
    Abstract: The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: July 3, 2018
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Pharmaceutical compositions comprising fatty acid esters
    Patent number: 10004807
    Abstract: The present invention relates to an injectable, pharmaceutical composition comprising a C1-6 alkyl ester of a C10-20 fatty acid. In an embodiment, the fatty acid is ethyl oleate, isopropyl oleate, ethyl myristate, or isopropyl myristate. These compositions are useful for the delivery of anti-psychotic drugs.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: June 26, 2018
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Jason M. Perry, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver
  • Pharmaceutical compositions comprising benzyl alcohol
    Patent number: 9999670
    Abstract: The present invention relates to a pharmaceutical composition comprising benzyl alcohol and polyoxyethylene derivatives of sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: June 19, 2018
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Jason M. Perry, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver
  • HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS
    Publication number: 20180162816
    Abstract: Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
    Type: Application
    Filed: January 19, 2018
    Publication date: June 14, 2018
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Pharmaceutical compositions comprising fatty glycerol esters
    Patent number: 9993556
    Abstract: The present invention relates to a pharmaceutical composition comprising glycerol esters of a fatty acid, wherein the compositions are useful for the delivery of anti-psychotic drugs.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: June 12, 2018
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Jason M. Perry, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver
  • Pharmaceutical compositions having improved storage stability
    Patent number: 9861699
    Abstract: The present invention relates to a pharmaceutical composition that provides long-term stability of a hydrolytically labile antipsychotic agent.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: January 9, 2018
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver, Michael J. Palmieri, Jr., Zhengzheng Pan
  • Pharmaceutical Compositions Having Improved Storage Stability
    Publication number: 20180000944
    Abstract: The present invention relates to a pharmaceutical composition that provides long-term stability of a hydrolytically labile antipsychotic agent
    Type: Application
    Filed: September 14, 2017
    Publication date: January 4, 2018
    Inventors: Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver, Michael J. Palmieri, JR., Zhengzheng Pan
  • Process for Synthesizing Oxidized Lactam Compounds
    Publication number: 20170267639
    Abstract: The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:
    Type: Application
    Filed: April 10, 2017
    Publication date: September 21, 2017
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan