Patents by Inventor Mark J. Macielag

Mark J. Macielag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazo[1,2-?]pyridine sulfonamides as TRPM8 modulators
    Patent number: 8618150
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: December 31, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, James J. McNally, Jay M. Matthews
  • PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS
    Publication number: 20130310358
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
    Type: Application
    Filed: July 25, 2013
    Publication date: November 21, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Steven J. Coats, Haiyan Bian, Peter J. Connolly, Giles Bignan, Chaozhong Cai, Scott L. Dax, Bart L. DeCorte, Shu-Chen Lin, Li Liu, Mark J. Macielag, Philip M. Pitis, Yue-Mei Zhang, Bin Zhu, Wei He
  • Amino-pyrrolidine-azetidine diamides as monoacylglycerol lipase inhibitors
    Patent number: 8575363
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R1, and R2 are defined herein.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: November 5, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Yue-Mei Zhang, Peter J. Connolly, Shu-Chen Lin, Mark J. MacIelag
  • PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLCEROL LIPASE INHIBITORS
    Publication number: 20130244998
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.
    Type: Application
    Filed: May 2, 2013
    Publication date: September 19, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Peter J. Connolly, Haiyan Bian, Xun Li, Li Liu, Mark J. Macielag, Mark E. McDonnell
  • AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130244997
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
    Type: Application
    Filed: May 1, 2013
    Publication date: September 19, 2013
    Applicant: Janssen Pharmaceutica NV
    Inventors: Haiyan Bian, Kristen Chevalier, Jose Clemente, Peter J. Connolly, Christopher M. Flores, Shu-Chen Lin, Li Liu, John Mabus, Mark J. Macielag, Mark E. McDonnell, Philip M. Pitis, Yue-Mei Zhang, Sui-Po Zhang, Bin Zhu
  • BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS
    Publication number: 20130245085
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Application
    Filed: April 30, 2013
    Publication date: September 19, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, Xiaoqing Xu
  • AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130237517
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
    Type: Application
    Filed: April 29, 2013
    Publication date: September 12, 2013
    Applicant: Janssen Pharmaceutica NV
    Inventors: Haiyan Bian, Kristen Chevalier, Jose Clemente, Peter J. Connolly, Christopher M. Flores, Shu-Chen Lin, Li Liu, John Mabus, Mark J. Macielag, Mark E. McDonnell, Philip M. Pitis, Yue-Mei Zhang, Sui-Po Zhang, Bin Zhu
  • Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors
    Patent number: 8513423
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: August 20, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Peter J. Connolly, Haiyan Bian, Xun Li, Li Liu, Mark J. Macielag, Mark E. McDonnell
  • Pyrimidine compounds as delta opioid receptor modulators
    Patent number: 8513271
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: August 20, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Steven J. Coats, Haiyan Bian, Peter J. Connolly, Gilles Bignan, Chaozhong Cai, Scott L. Dax, Bart L. DeCorte, Shu-Chen Lin, Li Liu, Mark J. Macielag, Philip M. Pitis, Yue-Mei Zhang, Bin Zhu, Wei He
  • Benzimidazole derivatives useful as TRPM8 channel modulators
    Patent number: 8450497
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: May 28, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, Xiaoqing Xu
  • PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130102584
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.
    Type: Application
    Filed: October 20, 2011
    Publication date: April 25, 2013
    Inventors: Peter J. Connolly, Haiyan Bian, Xun Li, Li Liu, Mark J. Macielag, Mark E. McDonnell
  • Hexahydro-cycloheptapyrazole cannabinoid modulators
    Patent number: 8378117
    Abstract: This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: February 19, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Fina Liotta, Mingde Xia, Huajun Lu, Meng Pan, Michael P. Wachter, Mark J. Macielag
  • 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS
    Publication number: 20120302541
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
    Type: Application
    Filed: October 28, 2010
    Publication date: November 29, 2012
    Inventors: Steven J. Coats, Haiyan Bian, Chaozhong Cai, Bart L. DeCorte, Li Liu, Mark J. Macielag, Scott L. Dax, Philip M. Pitis, Peter J. Connolly, Wei He
  • Pyrazines as delta opioid receptor modulators
    Patent number: 8293750
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: October 23, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Peter J. Connolly, Shu-Chen Lin, Mark J. Macielag, Yue-Mei Zhang
  • Benzimidazole derivatives useful as TRPM8 channel modulators
    Patent number: 8242157
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: August 14, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michele C. Jetter, Mark J. Macielag, Mingde Xia, Xiaoqing Xu
  • PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS
    Publication number: 20120202824
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.
    Type: Application
    Filed: April 20, 2012
    Publication date: August 9, 2012
    Inventors: Peter J. CONNOLLY, Shu-Chen Lin, Mark J. Macielag, Yue-Mei Zhang
  • SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20120190674
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
    Type: Application
    Filed: February 28, 2012
    Publication date: July 26, 2012
    Inventors: Shawn T. Branum, Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Michele C. Jetter, Yi Liu, Donald Ludovici, Mark J. Macielag, Jay M. Matthews, James J. McNally, Laura M. Reaney, Ronald K. Russell, Ning Qin, Christopher Teleha, Kenneth M. Wells, Scott C. Youells, Mark A. Youngman
  • IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20120149699
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Inventors: Mark J. Macielag, Mingde Xia, James J. McNally, Jay M. Matthews
  • Pyrazines as delta opioid receptor modulators
    Patent number: 8183371
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: May 22, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Peter J. Connolly, Shu-Chen Lin, Mark J. Macielag, Yue-Mei Zhang
  • AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20120101081
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R1, and R2 are defined herein.
    Type: Application
    Filed: October 20, 2011
    Publication date: April 26, 2012
    Inventors: Yue-Mei Zhang, Peter J. Connolly, Shu-Chen Lin, Mark J. MacIelag