Patents by Inventor Mark J. Macielag

Mark J. Macielag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR TREATING CB2 RECEPTOR MEDIATED PAIN
    Publication number: 20090215850
    Abstract: The present invention is directed to a method for treating, ameliorating or preventing CB2 receptor mediated pain in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I): or a form thereof, wherein X1R1, X2R2, X3R3, X4R4 and X5R5 are as defined herein.
    Type: Application
    Filed: February 27, 2008
    Publication date: August 27, 2009
    Inventors: Mingde Xia, Mark J. Macielag, Christopher M. Flores, Kevin Paul Pavlick
  • 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES
    Publication number: 20090156577
    Abstract: The present invention relates to compounds having a structure according to Formula (I) wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
    Type: Application
    Filed: November 11, 2008
    Publication date: June 18, 2009
    Inventors: Benjamin Davis, Eugene B. Grant, III, Shu-Chen Lin, Mark J. Macielag, Michele Ann Weidner-Wells, Xiaoqing Xu, Xiaodong Xu, Bin Zhu
  • C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents
    Publication number: 20090029980
    Abstract: The present invention relates to C-7 isoxazolyl quinoline/naphthyridine derivatives useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said derivatives and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes.
    Type: Application
    Filed: July 28, 2008
    Publication date: January 29, 2009
    Inventors: Mark J. Macielag, Michele A. Weidner-Wells, Shu-Chen Lin
  • METHOD FOR TREATING CB2 RECEPTOR MEDIATED PAIN
    Publication number: 20080234347
    Abstract: The present invention is directed to a method for treating, ameliorating or preventing CB2 receptor mediated pain in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I): or a form thereof, wherein X1R1, X2R2, X3R3, X4R4 and X5R5 are as defined herein.
    Type: Application
    Filed: February 27, 2008
    Publication date: September 25, 2008
    Inventors: Mingde Xia, Mark J. Macielag, Christopher M. Flores, Kevin Paul Pavlick
  • Hexahydro-Cyclooctyl Pyrazole Cannabinoid Modulators
    Publication number: 20080076814
    Abstract: This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
    Type: Application
    Filed: March 20, 2007
    Publication date: March 27, 2008
    Inventors: Mingde Xia, Fina Liotta, Huajun Lu, Meng Pan, Michael P. Wachter, Mark J. Macielag
  • Hexahydro-Cycloheptapyrazole Cannabinoid Modulators
    Publication number: 20080070968
    Abstract: This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
    Type: Application
    Filed: March 20, 2007
    Publication date: March 20, 2008
    Inventors: Fina Liotta, Mingde Xia, Huajun Lu, Meng Pan, Michael P. Wachter, Mark J. Macielag
  • ANTIMICROBIAL OXAZOLIDINONE PRODRUGS
    Publication number: 20080027053
    Abstract: This invention includes oxazolidinone prodrug compounds of Formula (I) and Formula (II) as defined herein. The prodrugs are convertible by natural biological processes into an active ingredient possessed of antimicrobial properties useful in treating bacterial infections in mammals.
    Type: Application
    Filed: July 9, 2007
    Publication date: January 31, 2008
    Inventors: Mark J. Macielag, Manomi A. Tennakoon
  • Cyclohexyl derivatives as selective estrogen receptor modulators
    Patent number: 7183445
    Abstract: The present invention is directed to novel cyclohexyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: February 27, 2007
    Assignee: Janssen Pharmaceutica N.V
    Inventors: Nareshkumar F. Jain, Mark J. Macielag, William V. Murray, Raymond A. Ng, Zhihua Sui
  • 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
    Patent number: 7179805
    Abstract: The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: February 20, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Eugene B. Grant, III, Mark J. Macielag, Xiaoqing Xu, Steven David Paget, Michele Ann Weidner-Wells
  • Benzo[4,5]thieno[2,3-c]pyridine and Benzo[4,5]furo[2,3-c]pyridine Derivatives Useful as Inhibitors of Phosphodiesterase
    Patent number: 6864253
    Abstract: The present invention relates to novel ?-carboline derivatives of the general formula wherein all the variables are as described within the specification, useful as phosphodiesterase inhibitors. The present invention further relates to use of the described derivatives for the treatment of diseases and conditions related to PDE, for example male erectile dysfunction.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: March 8, 2005
    Assignee: Orth-McNeil Pharmaceutical, Inc.
    Inventors: Zhihua Sui, Mark J. Macielag
  • 6-O-acyl ketolide antibacterials
    Patent number: 6825170
    Abstract: 6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: November 30, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Todd C. Henninger, Mark J. Macielag, Manomi A. Tennakoon, Xiaodong Xu
  • 3-descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents
    Patent number: 6825172
    Abstract: 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: wherein R1, W, R3, R4, R5, R6, X, X′, and Z are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: November 30, 2004
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Todd C. Henninger, Mark J. Macielag, Brett A. Marinelli, Bin Zhu
  • Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
    Patent number: 6818646
    Abstract: The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: November 16, 2004
    Inventors: Zhihua Sui, Mark J. Macielag, Jihua Guan, Weigin Jiang, James C. Lanter
  • Neurotrophic pyrrolidines and piperidines, and related compositions and methods
    Patent number: 6809107
    Abstract: This invention provides compounds having the following general structures: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized by neuronal damage.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: October 26, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ramesh M. Kanojia, Alfonzo D. Jordan, Allen B. Reitz, Mark J. Macielag, Boyu Zhao
  • Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone
    Publication number: 20040092505
    Abstract: The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the compounds of the invention are antagonists of follicle stimulating hormone, a hormone associated with the human reproductive system.
    Type: Application
    Filed: April 14, 2003
    Publication date: May 13, 2004
    Inventors: Steven J. Coats, Louis J. Fitzpatrick, Dennis J. Hlasta, Carolina L. Lanter, Mark J. Macielag, Ke Pan, Ralph A. Rivero, Stephen S. Palmer
  • 6-O-carbamate-11,12-lacto-ketolide antimicrobials
    Patent number: 6713455
    Abstract: 6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: wherein R1, R2, R3 R7, and R8 are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: March 30, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Eugene B. Grant, III, Todd C. Henninger, Mark J. Macielag, Deodialsingh Guiadeen
  • Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
    Publication number: 20040044021
    Abstract: The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): 1
    Type: Application
    Filed: August 11, 2003
    Publication date: March 4, 2004
    Inventors: Zhihua Sui, Mark J. Macielag, Jihua Guan, Weigin Jiang, James C. Lanter
  • 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents
    Publication number: 20040018994
    Abstract: 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 29, 2004
    Inventors: Todd C. Henninger, Mark J. Macielag, Brett A. Marinelli, Bin Zhu
  • 6-O-acyl ketolide antibacterials
    Publication number: 20030220272
    Abstract: 6-O-Acyl ketolide antibacterials of the formula: 1
    Type: Application
    Filed: November 21, 2002
    Publication date: November 27, 2003
    Inventors: Todd C. Henninger, Mark J. Macielag, Manomi A. Tennakoon, Xiaodong Xu
  • Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
    Patent number: 6635638
    Abstract: The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: October 21, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Zhihua Sui, Mark J. Macielag, Jihua Guan, Weiqin Jiang, James C. Lanter