Abstract: A particulate filtration device is suggested, comprising an inlet for an inflow of a gas stream which is particle-laden, an outlet for an outflow of the gas stream having a significantly reduced particulate load, a main filter section, which is arranged within a flow path of the gas stream between the inlet and the outlet and which comprises a filtration medium, and a prefilter chamber, which is arranged upstream of the main filter section and which comprises an inertial filter element, having several perforations, wherein the perforations of the inertial filter element are arranged within the flow path of the gas stream in such a way that when the flow path of the gas stream is passing through the perforations, an inertial separation of the particulates from the mean flow path of the gas stream is achieved.

Abstract: Apparatuses, systems, and methods for prosthetic valves. Embodiments of prosthetic valves may include sealing bodies configured for an anchor to at least partially pass through. The pass through may allow for the sealing body to seal to a portion of a patient's heart in the event of a miscapture of a leaflet by the anchor. Embodiments may include modular valve systems and prosthetic valves including anchors for coupling to chordae, trabeculae, or papillary structures of a patient's heart. Embodiments may include prosthetic valves including anchors for engaging calcification of a patient's native valve.

Abstract: Embodiments of a prosthetic heart valve comprise an annular main body, an atrial cap extending radially outwardly from the atrial end of the main body, and a plurality of ventricular anchors extending outwardly from the ventricular end of the main body. Each ventricular anchor can have a proximal end portion connected to the ventricular end, an intermediate portion extending away from the atrial end and then back toward the atrial so as to define a first bend, and a free distal end portion that extends from the intermediate portion. The distal end portion can comprise a first section, a second section, and a second bend between the first and second sections, the first section extending from the intermediate portion in a direction toward the atrial end and radially away from the main body.

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

Abstract: A system includes a photovoltaic module having photovoltaic cells, each having a width, and a roofing shingle having an exposure zone and a headlap zone. A plurality of slots extends from the exposure zone to the headlap zone and define tooth portions. A first one of the tooth portions has a first side defined by a first slot and a second side defined by a second slot adjacent to the first slot. The first tooth portion has a first width that is the photovoltaic cell width multiplied by a first positive integer. A second tooth portion has a first side defined by a third slot and a second side defined by a fourth slot adjacent to the third slot. The second tooth portion has a second width that is the photovoltaic cell width multiplied by a second positive integer different than the first positive integer.

Abstract: Multiple, separately administrated computer systems storing slices of the cipher text of a Personally Identifiable Information (PII) data item that is represented by a token. The token is used as a substitute of the data item. The data item is encrypted using a public key. To recover the data item, a complete set of the slices is retrieved from the separate computer systems and decrypted using the private key corresponding to the public key. Instances and circumstances of the usages of the data item can be recorded under the token in a blockchain ledger in connection with the retrieval and/or decryption of the cipher text. A data item owner may use the data item and the public key to recreate the cipher text, retrieve the token stored with the cipher text in the separate computer systems, and then query the ledger for a usage history of the data item.

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

Abstract: A poppet valve device is proposed, comprising a valve stem, a poppet, having a sealing surface and being formed separately from the valve stem, wherein the poppet is actuatable via the valve stem, and wherein, following an imaginary line parallel to a longitudinal direction of the valve stem along the closing direction of the poppet, the sealing surface is passed before a front end of the valve stem is passed.

Abstract: This disclosure provides crystalline forms of trofinetide and trofinetide hydrate, pharmaceutical compositions comprising crystalline forms of trofinetide and trofinetide hydrate, methods of making crystalline forms of trofinetide or trofinetide hydrate, and methods of treating a disease, condition, or disorder in a subject comprising administering a composition comprising crystalline forms of trofinetide or trofinetide hydrate to the subject.

Abstract: A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment, including either suspending or adjusting turn schedule based on various types of patient movement. Compliance with Head-of-Bed protocols can also be performed based on actual patient position instead of being inferred from bed elevation angle.

Abstract: A system includes a photovoltaic module having photovoltaic cells, each having a width, and a roofing shingle having an exposure zone and a headlap zone. A plurality of slots extends from the exposure zone to the headlap zone and define tooth portions. A first one of the tooth portions has a first side defined by a first slot and a second side defined by a second slot adjacent to the first slot. The first tooth portion has a first width that is the photovoltaic cell width multiplied by a first positive integer. A second tooth portion has a first side defined by a third slot and a second side defined by a fourth slot adjacent to the third slot. The second tooth portion has a second width that is the photovoltaic cell width multiplied by a second positive integer different than the first positive integer.

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

Abstract: A particulate filtration device is suggested, comprising an inlet for an inflow of a gas stream which is particle-laden, an outlet for an outflow of the gas stream having a significantly reduced particulate load, a main filter section, which is arranged within a flow path of the gas stream between the inlet and the outlet and which comprises a filtration medium, and a prefilter chamber, which is arranged upstream of the main filter section and which comprises an inertial filter element, having several perforations, wherein the perforations of the inertial filter element are arranged within the flow path of the gas stream in such a way that when the flow path of the gas stream is passing through the perforations, an inertial separation of the particulates from the mean flow path of the gas stream is achieved.

Abstract: Apparatuses and methods for loading and deploying implants from delivery apparatuses. The apparatuses in certain embodiments may comprise crimping devices for compressing an implant for insertion into a portion of a delivery apparatus. The apparatuses in certain embodiments may comprise features of delivery apparatuses allowing for improved loading and deployment of an implant from the delivery apparatuses.

Abstract: A poppet valve device is proposed, comprising a valve stem, a poppet, having a sealing surface and being formed separately from the valve stem, wherein the poppet is actuatable via the valve stem, and wherein, following an imaginary line parallel to a longitudinal direction of the valve stem along the closing direction of the poppet, the sealing surface is passed before a front end of the valve stem is passed.

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: A modeling system may generate a function model and a corresponding functional complexity score (FCS) for display on a graphical user interface (GUI). The FCS may be calculated by looping through each level of the function model and determining a score based on both hierarchical relationships and functional relationships within the function model at each level. The modeling system may constantly monitor for additional inputs representative of an additional function or changes to current functions and automatically update the FCS displayed on the GUI based on the additional inputs.