Abstract: Systems and methods for cleaning a heat recovery steam generator system including tubes and fins associated therewith using deep cleaning alignment equipment are described. The deep cleaning alignment equipment primarily includes at least one wedge and at least one wand. The wedge may be an elongate wedge configured to maximize the surface area that contacts the tubes and fins, which in turn minimizes the amount of stress about any specific point of the tubes or the fins. Additionally, the wedge may be made of a variety of different materials. The wedge may include multiple pieces that can be releasably secured together. The wedge may also have at least one opening formed therein to assist in removal of the wedge from the system.

Abstract: Described herein are biodegradable drug delivery conjugates and anti-cancer conjugates for effectively delivering anti-cancer agents to a subject. The conjugates include a single first cleavable peptide linker covalently connected to two polymeric segments, wherein at least one PD-L1 inhibitor is covalently bonded to each polymeric segment (referred to herein as “a PD-L1 inhibitor polymer conjugate”). Also described herein is the use of the PD-L1 inhibitor polymer conjugates in combination with anticancer agents to treat or prevent cancer.

Abstract: Dosing unit for dosing liquids, having a fluid unit for selectively providing an overpressure and a negative pressure on a working gas, which is accommodated in a fluid channel which is connected at a first end region to the fluid unit and which includes a second end region, having a first valve unit and having a second valve unit, which are arranged spaced apart from one another along the fluid channel and are each designed for selectively blocking or releasing the fluid channel, wherein a fluid reservoir is delimited by the first and second valve units, the fluid reservoir storing a working gas. The dosing unit further includes a control unit for controlling the valve units, the fluid reservoir being assigned a pressure sensor which is designed to provide a pressure signal as a function of a working gas pressure and is electrically connected to the control unit.

Abstract: A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment, including either suspending or adjusting turn schedule based on various types of patient movement. Compliance with Head-of-Bed protocols can also be performed based on actual patient position instead of being inferred from bed elevation angle.

Abstract: A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment, including either suspending or adjusting turn schedule based on various types of patient movement. The sensor can include one or more of bi-axial or tri-axial accelerometers, magnetometers and altimeters as well as resistive, inductive, capacitive, magnetic and other sensing devices, depending on whether the sensor is located on the patient or the support surface, and for what purpose.

Abstract: Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. The methods involve combining tissue with a processing solution in a processing vessel and applying resonant acoustic energy thereto. In some instances, the tissue is processed in the absence of processing solution. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue homogenization, tissue cleansing, and tissue decontamination, and assessment of microbial load.

Abstract: Dosing unit for dosing liquids, having a fluid unit for selectively providing an overpressure and a negative pressure on a working gas, which is accommodated in a fluid channel which is connected at a first end region to the fluid unit and which includes a second end region, having a first valve unit and having a second valve unit, which are arranged spaced apart from one another along the fluid channel and are each designed for selectively blocking or releasing the fluid channel in order to form in the fluid channel a fluid reservoir which is delimited by the two valve units and is provided for storing working gas, having a control unit for controlling the valve units, the fluid reservoir being assigned a pressure sensor which is designed to provide a pressure signal as a function of a working gas pressure and is electrically connected to the control unit.

Abstract: A system includes a photovoltaic module having photovoltaic cells, each having a width, and a roofing shingle having an exposure zone and a headlap zone. A plurality of slots extends from the exposure zone to the headlap zone and define tooth portions. A first one of the tooth portions has a first side defined by a first slot and a second side defined by a second slot adjacent to the first slot. The first tooth portion has a first width that is the photovoltaic cell width multiplied by a first positive integer. A second tooth portion has a first side defined by a third slot and a second side defined by a fourth slot adjacent to the third slot. The second tooth portion has a second width that is the photovoltaic cell width multiplied by a second positive integer different than the first positive integer.

Abstract: A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[2-fluorophenyl)methyl]oxy}phenyl-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.

Abstract: A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment, including either suspending or adjusting turn schedule based on various types of patient movement. The sensor can include one or more of bi-axial or tri-axial accelerometers, magnetometers and altimeters as well as resistive, inductive, capacitive, magnetic and other sensing devices, depending on whether the sensor is located on the patient or the support surface, and for what purpose.

Abstract: Systems and methods for detecting design redundancies and conflicts of a product or process are disclosed in the present application. A system for detecting redundancies and conflicts may parse a plurality of descriptions of functions to identify objects, verbs, and modifiers corresponding to descriptions of the plurality of descriptions. The system may determine lexical relationships between the identified objects, verbs, and modifiers based on lexical relationships. The system may determine dependencies of hierarchal relationships within the function model, and detect redundancies and conflicts based on the lexical relationships and the hierarchal relationships.

Abstract: A heart valve prosthesis for replacing a native mitral valve includes a self-expanding frame with a plurality of anchoring members disposed along the lower region. A valve body is positioned within the self-expanding frame and includes a plurality of leaflets configured to allow blood flow through the self-expanding frame in only one direction. A skirt surrounds the self-expanding frame and is spaced apart therefrom for contacting surrounding tissue and impeding blood flow around the self-expanding frame. The skirt may be reinforced with wires to help maintain a desired shape. The leaflets in the valve body are preferably connected to the self-expanding frame through one or more intermediate components such that the valve body is spaced radially inwardly from an inner surface of the self-expanding frame.

Abstract: A method for replacing a native heart valve includes advancing a delivery catheter having a valve prosthesis disposed along a distal end portion thereof, wherein the valve includes an inner frame having an hourglass shape and an outer sealing frame connected to and surrounding the inner frame. A valve body is mounted within the inner frame and includes a plurality of leaflets. The leaflets have longitudinal curvatures when in an open position, wherein the curvatures are shaped for conforming to the curved interior surface of the inner frame. This combination of features reduces the possibility of blood stagnating between the leaflets and inner frame, which reduces the possibility of thrombus formation.

Abstract: A solenoid-operated valve assembly that reduces the jet flow of fluid or gas in an axially exiting valve. The valve assembly comprises a spool valve, a valve member housing, and a flow path. The spool valve comprises a fluid communication channel, a tail, and an inlet seat. The valve member housing comprises at least one inlet, at least one nozzle flow director, and at least one outlet. The flow path begins at the at least one inlet and exits at the at least one outlet. The at least one nozzle flow director is within the flow path. The spool valve moves axially within the valve member housing between a closed position and an open position. The inlet seat closes the at least one flow path at the inlet when the spool valve is in the closed position. A method of operation of the solenoid-operated valve assembly is also provided.

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment, including either suspending or adjusting turn schedule based on various types of patient movement. The sensor can include bi-axial or tri-axial accelerometers, as well as resistive, inductive, capacitive, magnetic and other sensing devices, depending on whether the sensor is located on the patient or the support surface, and for what purpose.

Abstract: Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof. Also provided herein are novel intermediates used in this process and their preparation.