Patents by Inventor Michael P. Wachter

Michael P. Wachter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydro-indazole cannabinoid modulators
    Patent number: 7452997
    Abstract: This invention is directed to a tetrahydro-indazole cannabinoid modulator compound of formula I: and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: November 18, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Bharat Lagu, Fina Liotta, Meng Pan, Michael P. Wachter, Mingde Xia Xia
  • Hexahydro-Cyclooctyl Pyrazole Cannabinoid Modulators
    Publication number: 20080076814
    Abstract: This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
    Type: Application
    Filed: March 20, 2007
    Publication date: March 27, 2008
    Inventors: Mingde Xia, Fina Liotta, Huajun Lu, Meng Pan, Michael P. Wachter, Mark J. Macielag
  • Hexahydro-Cycloheptapyrazole Cannabinoid Modulators
    Publication number: 20080070968
    Abstract: This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
    Type: Application
    Filed: March 20, 2007
    Publication date: March 20, 2008
    Inventors: Fina Liotta, Mingde Xia, Huajun Lu, Meng Pan, Michael P. Wachter, Mark J. Macielag
  • Acetylenic compounds useful in treating inflammatory disorders
    Patent number: 7338952
    Abstract: This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: March 4, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Scott Beers, Elizabeth A. Malloy, Michael P. Wachter
  • METHOD OF USE FOR SUBSTITUTED DIPIPERIDINE CCR2 ANTAGONISTS
    Publication number: 20070219245
    Abstract: The present invention is directed to a method for use of substituted dipiperidine compounds of Formula (I) or a salt, isomer, prodrug, metabolite or polymorph thereof, which are CCR2 antagonists, for preventing, treating or ameliorating syndromes, disorders or diseases related to CCR2 activation in a subject in need thereof.
    Type: Application
    Filed: March 13, 2007
    Publication date: September 20, 2007
    Inventors: Cuifen Hou, Yin Liang, Keith T. Demarest, Druie E. Cavender, Michael P. Wachter, Mingde Xia
  • Substituted imidazoles useful in the treatment of inflammatory diseases
    Patent number: 7041686
    Abstract: This invention relates to substituted imidazoles of Formula I pharmaceutical compositions containing them, methods of using them and intermediates useful in their manufacture. The compounds of the invention modulate the production of a number of inflammatory cytokines and are useful in the treatment of diseases associated with the overproduction of inflammatory cytokines.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: May 9, 2006
    Inventors: Scott Beers, Michael P. Wachter
  • Acetylenic compound useful in treating inflammatory disorders
    Patent number: 7022703
    Abstract: This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: April 4, 2006
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Scott Beers, Elizabeth A. Malloy, Michael P. Wachter
  • Substituted imidazoles useful in the treatment of inflammatory diseases
    Publication number: 20040214816
    Abstract: This invention relates to substituted imidazoles of Formula I 1
    Type: Application
    Filed: October 17, 2001
    Publication date: October 28, 2004
    Inventors: Scott Beers, Michael P. Wachter
  • Substituted imidazoles useful in the treatment of inflammatory diseases
    Patent number: 6521655
    Abstract: This invention relates to a series of substituted imidazoles of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: February 18, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Scott A. Beers, Elizabeth A. Malloy, Michael P. Wachter, Wei Wu
  • Substituted amino acids as neutral sphingomyelinase inhibitors
    Patent number: 6306911
    Abstract: This invention relates to a series of substituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules that bind to neutral sphingomyelinase and inhibit its activity.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: October 23, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael P. Wachter, Praful Lalan
  • Substituted imidazoles useful in the treatment of inflammatory diseases
    Patent number: 6214830
    Abstract: This invention relates to a series of substituted imidazoles of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: April 10, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Scott A. Beers, Elizabeth A. Malloy, Michael P. Wachter, Wei Wu
  • 2-substituted imidazoles useful in the treatment of inflammatory diseases
    Patent number: 6040320
    Abstract: This invention relates to substituted imidazoles of Formula I ##STR1## pharmaceutical compositions containing them, methods of using them and intermediates useful in their manufacture. The compounds of the invention modulate the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with the production of inflammatory cytokines.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: March 21, 2000
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Scott A. Beers, Elizabeth A. Malloy, Michael P. Wachter, Wei Wu
  • Substituted imidazoles useful in the treatment of inflammatory disease
    Patent number: 5965583
    Abstract: This invention relates to a series of substituted imidazoles of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: October 12, 1999
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Scott A. Beers, Elizabeth A. Malloy, Michael P. Wachter, Wei Wu
  • Arylpyrazoles as leukotriene inhibitors
    Patent number: 5869674
    Abstract: Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: February 9, 1999
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Ferro, Michael P. Wachter
  • Arylpyrazoles as leukotriene inhibitors
    Patent number: 5843958
    Abstract: Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: December 1, 1998
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Ferro, Michael P. Wachter
  • Substituted triazoles as angiotensin II inhibitors
    Patent number: 5508419
    Abstract: This invention relates to novel bis-biphenyl substituted 3-mercapto-1,2,4-tetrazoles and to pharmaceutically acceptable salts thereof.The compounds are angiotensin II receptor antagonists, and are useful in treating hypertension (lowering high blood pressure), congestive heart failure, elevated ocular pressure, cerebral stroke, angina, cardiac insufficiency, myocardial infarction or diabetic nephropathy.The invention also relates to a pharmaceutical composition comprising a compound of the invention, a method of treating a physiological condition in a mammal that is mediated by angiotensin II which comprises administering to the mammal an effective amount of a compound of the invention, and novel processes for preparing the compounds of the invention.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: April 16, 1996
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Victor T. Bandurco, William V. Murray, Michael P. Wachter, Charles F. Schwender
  • Diaryl-substituted heterocyclic compounds, drugs and cosmetics obtained therefrom
    Patent number: 5475017
    Abstract: Compounds of formula I ##STR1## and compounds of formula Ia ##STR2## and their physiologically tolerated salts, processes for their preparation and drugs and cosmetics prepared therefrom.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: December 12, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Heiner Wuest, Bernd Janssen, William V. Murray, Michael P. Wachter, Stanley Bell
  • Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole intermediate compounds
    Patent number: 5387693
    Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: February 7, 1995
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Peter J. Connolly, Michael P. Wachter
  • Substituted triazoles as angiotensin II inhibitors
    Patent number: 5347011
    Abstract: This invention relates to novel bis-biphenyl substituted 3-mercapto-1,2,4-tetrazoles and to pharmaceutically acceptable salts thereof.The compounds are angiotensin II receptor antagonists, and are useful in treating hypertension (lowering high blood pressure), congestive heart failure, elevated ocular pressure, cerebral stroke, angina, cardiac insufficiency, myocardial infarction or diabetic nephropathy.The invention also relates to a pharmaceutical composition comprising a compound of the invention, a method of treating a physiological condition in a mammal that is mediated by angiotensin II which comprises administering to the mammal an effective amount of a compound of the invention, and novel processes for preparing the compounds of the invention.
    Type: Grant
    Filed: June 7, 1993
    Date of Patent: September 13, 1994
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Victor T. Bandurco, William V. Murray, Michael P. Wachter, Charles F. Schwender
  • Diaryl-substituted heterocyclic compounds, their preparation and drigs and cosmetics obtained therefrom
    Patent number: 5338749
    Abstract: Compounds of formula I ##STR1## and compounds of formula Ia ##STR2## where the substituents are as defined in the specification.
    Type: Grant
    Filed: November 6, 1992
    Date of Patent: August 16, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Heiner Wuest, Bernd Janssen, William V. Murray, Michael P. Wachter, Stanley Bell