Patents by Inventor Michael P. Wachter

Michael P. Wachter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds
    Patent number: 5315012
    Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
    Type: Grant
    Filed: September 9, 1993
    Date of Patent: May 24, 1994
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Peter J. Connolly, Michael P. Wachter
  • Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors
    Patent number: 5250561
    Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: October 5, 1993
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Peter J. Connolly, Michael P. Wachter
  • Substituted N-biphenylyl lactams
    Patent number: 5246940
    Abstract: This invention relates to novel N-biphenylyl lactam compounds having a substituted methylidene or methyl moiety adjacent to the lactam nitrogen, and pharmaceutically acceptable salts thereof.The compounds are angiotensin II receptor antagonists, and are useful in treating hypertension (lowering high blood pressure), congestive heart failure, elevated ocular pressure, cerebral stroke, angina, cardiac insufficiency, myocardial infarction or diabetic nephropathy.The invention also relates to a pharmaceutical composition comprising a compound of the invention, a method of treating a physiological condition in a mammal that is mediated by angiotensin II which comprises administering to the mammal an effective amount of a compound of the invention, and novel processes for preparing the compounds of the invention.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: September 21, 1993
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: William V. Murray, Michael P. Wachter
  • Pharmacologically active N-1 and C-5 heterocyclic pyrazoles and method for synthesizing the same
    Patent number: 5242940
    Abstract: N-1 and C-5 heterocyclic pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.
    Type: Grant
    Filed: December 17, 1991
    Date of Patent: September 7, 1993
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Wachter, William V. Murray
  • Substituted triazoles as angiotensin II inhibitors
    Patent number: 5240953
    Abstract: This invention relates to novel bis-biphenyl substituted 3-mercapto-1,2,4-tetrazoles and to pharmaceutically acceptable salts thereof.The compounds are angiotensin II receptor antagonists, and are useful in treating hypertension (lowering high blood pressure), congestive heart failure, elevated ocular pressure, cerebral stroke, angina, cardiac insufficiency, myocardial infection or diabetic nephropathy.The invention also relates to pharmaceutical composition comprising a compound of the invention, a method of treating a physiological condition in a mammal that is mediated by angiotensin II which comprises administering to the mammal an effective amount of a compound of the invention, and novel processes for preparing the compounds of the invention.
    Type: Grant
    Filed: January 30, 1992
    Date of Patent: August 31, 1993
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Victor T. Bandurco, William V. Murray, Michael P. Wachter, Charles F. Schwender
  • Diaryl-substituted pyrazole compounds and drugs and cosmetics obtained therefrom
    Patent number: 5206242
    Abstract: Compounds of formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen or methyl,A is en ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo,L is a saturated or unsaturated five-membered or six-membered heterocyclic structure which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.6 -alkyl, or C.sub.1 -C.sub.4 -alkanoyl and has from 1 to 3 heteroatoms from the group consisting of N, O and S, the second and third heteroatoms being a nitrogen atom,R.sup.3 is hydrogen, a hydroxy or C.sub.1 -C.sub.6 -alkoxy group,R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy,R.sup.5 is hydrogen or methoxy or tert-butyl,R.sup.6 is hydrogen, methyl, nitrile or a C.sub.2 -C.sub.10 -ketal group or the radical --CHR.sup.7 OR.sup.8 --CHR.sup.7 --NR.sup.9 R.sup.10, --COR.sup.11, --SR.sup.12, ##STR2## in which R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: April 27, 1993
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Heiner Wuest, Bernd Janssen, William V. Murray, Michael P. Wachter, Stanley Bell
  • Diaryl-substituted heterocyclic compounds, their preparation and drugs and cosmetics obtained therefrom
    Patent number: 5196532
    Abstract: Compounds of formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen or methyl, A is an ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo,L is a saturated or unsaturated five-membered or six-membered heterocyclic structure which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.6 -alkyl, or C.sub.1 -C.sub.4 -alkanoyl and has from 1 to 3 heteroatoms from the group consisting of N, O and S, the second and third heteroatoms being a nitrogen atom,R.sup.3 is hydrogen, a hydroxy or C.sub.1 -C.sub.6 -alkoxy group,R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy,R.sup.5 is hydrogen or methoxy or tert-butyl,R.sup.6 is hydrogen methyl, nitrile or a C.sub.2 -C.sub.10 -ketal group or the radical --CHR.sup.7 OR.sup.8 --CHR.sup.7 --NR.sup.9 R.sup.10, --COR.sup.11, --SR.sup.12, ##STR2## in which R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.
    Type: Grant
    Filed: June 18, 1991
    Date of Patent: March 23, 1993
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Heiner Wuest, Bernd Janssen, William V. Murray, Michael P. Wachter, Stanley Bell
  • Substituted n-biphenylyl lactams
    Patent number: 5182288
    Abstract: This invention relates to novel N-biphenylyl lactam compounds having a substituted methylidene or methyl moiety adjacent to the lactam nitrogen, and pharmaceutically acceptable salts thereof.The compounds are angiotensin II receptor antagonists, and are useful in treating hypertension (lowering high blood pressure), congestive heart failure, elevated ocular pressure, cerebral stroke, angina, cardiac insufficiency, myocardial infarction or diabetic nephropathy.The invention also relates to a pharmaceutical composition comprising a compound of the invention, a method of treating a physiological condition in a mammal that is mediated by angiotensin II which comprises administering to the mammal an effective amount of a compound of the invention, and novel processes for preparing the compounds of the invention.
    Type: Grant
    Filed: November 13, 1991
    Date of Patent: January 26, 1993
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: William V. Murray, Michael P. Wachter
  • Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
    Patent number: 5164381
    Abstract: 1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: November 17, 1992
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Wachter, Michael P. Ferro
  • Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
    Patent number: 5134155
    Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
    Type: Grant
    Filed: August 8, 1991
    Date of Patent: July 28, 1992
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Peter J. Connolly, Michael P. Wachter
  • Phenylhydrazones, the manufacture thereof and therapeutic and cosmetic compositions prepared therefrom
    Patent number: 5072042
    Abstract: Phenylhydrazones of formula I ##STR1## in which R.sup.1 to R.sup.6 and m and n have the meanings stated above, and the manufacture thereof. The substances are suitable for combating disease and for cosmetic use.
    Type: Grant
    Filed: February 8, 1990
    Date of Patent: December 10, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Janssen, Hans-Heiner Wuest, William V. Murray, Michael P. Wachter, Stanley Bell
  • Diaryl-substituted heterocyclic compounds, drugs and cosmetics obtained therefrom
    Patent number: 5061705
    Abstract: Compounds of formula I ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen or methyl, A is an ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo, L is a saturated or unsaturated five-membered or six-membered heterocyclic structure which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.6 -alkyl, or C.sub.1 -C.sub.4 -alkanoyl and has from 1 to 3 heteroatoms from the group consisting of N, O and S, the second and third heteroatoms being a nitrogen atom,R.sup.3 is hydrogen, a hydroxy or C.sub.1 -C.sub.6 -alkoxy group,R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy,R.sup.5 is hydrogen or methoxy or tert-butyl,R.sup.6 is hydrogen, methyl, nitrile or a C.sub.2 -C.sub.10 -ketal group or the radical --CHR.sup.7 OR.sup.8 --CHR.sup.7 --NR.sup.9 R.sup.10, --COR.sup.11, --SR.sup.12, ##STR2## in which R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.
    Type: Grant
    Filed: February 8, 1990
    Date of Patent: October 29, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans H. Wuest, Bernd Janssen, William V. Murray, Michael P. Wachter, Stanley Bell
  • Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides
    Patent number: 5051518
    Abstract: 2- and 3-substituted (1',5'-diaryl-3'-pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: September 24, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: William V. Murray, Michael P. Wachter
  • 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins
    Patent number: 4910198
    Abstract: The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: March 20, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Wachter, Donald S. Karanewsky
  • Regioselective synthesis of a 1,5-disubstituted pyrazole
    Patent number: 4898952
    Abstract: A highly regioselective synthesis of pyrazoles from a mono-substituted hydrazine and a .beta.-dicarbonyl compound wherein a carboxylic acid moiety is present on the substituent attached to one of the carbonyls.
    Type: Grant
    Filed: February 6, 1989
    Date of Patent: February 6, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: William V. Murray, Michael P. Wachter
  • Process of preparing 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins
    Patent number: 4855426
    Abstract: The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: August 8, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Wachter, Donald S. Karanewsky
  • 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
    Patent number: 4826868
    Abstract: 1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.
    Type: Grant
    Filed: April 29, 1987
    Date of Patent: May 2, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Wachter, Michael P. Ferro
  • Amido substituted naphthalenes and intermediates thereof
    Patent number: 4814487
    Abstract: The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.
    Type: Grant
    Filed: May 7, 1987
    Date of Patent: March 21, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: William V. Murray, Michael P. Wachter
  • Epoxides useful as antiallergic agents
    Patent number: 4783483
    Abstract: Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R.sup.1 =H or CH.sub.3 ; R.sup.2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R.sup.4 and R.sup.5 =alkyl; n=O or 1; and R.sup.3 is as described.
    Type: Grant
    Filed: December 29, 1986
    Date of Patent: November 8, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Ferro, Michael P. Wachter
  • 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins and use in treatment of ulcers
    Patent number: 4761413
    Abstract: The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: August 2, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Wachter, Donald S. Karanewsky