Abstract: A refillable container for a stick type cosmetic product comprising a cap, a refill cartridge and a base assembly. The base assembly comprises an outer shell and a button member. The refill cartridge is configured to be detachably received at least partially within a cavity of the outer shell of the base assembly such that the refill cartridge may be removed and replaced from said base assembly by pressing the button member provided in the base assembly.

Abstract: A dropper package for dispensing and applying a fluid product, comprising a container body for storing the fluid product and a dropper assembly coupled to one end of the container body. The dropper assembly comprises a deformable bulb, a tube with its proximal end connected to the deformable bulb, and an applicator tip connected to a distal end of the tube. The applicator tip comprises two main application faces that are opposite to each other and a central through cavity that opens to the outside from both the main application faces. The applicator tip includes a dispensing channel that is in fluid communication with a channel of the tube and terminates in a dispensing orifice that opens into the central through cavity. The dropper package is adapted to apply and dispense the fluid product in a very controlled manner as well as massage the user's keratinous surface.

Abstract: A dispenser for dispensing a liquid product, the dispenser comprising a housing, a pump assembly, a dispensing head, and an inner container. The inner container accommodates the liquid product and is configured to be inserted into a cavity of the housing. The inner container is replaceable and detachably connected to the housing such that the housing, the pump assembly, and the dispensing head can be retained for reuse while the inner container can be replaced with a new inner container. A protrusion is provided on an underside of the inner container that a user can grip to rotate the inner container in a clockwise or anticlockwise direction to disengage the inner container from the housing.

Abstract: An applicator head for applying a fluid product including a cosmetic, care, or pharmaceutical product onto the keratinous substrate. The applicator head includes an applying member elongated along a longitudinal axis. The applying member has tubular body with a closed proximal end and an open distal end. The applying member includes a sidewall and an interior longitudinal cavity having an opening at the open distal end of the applying member. The applying member, at its distal end portion, has a ball socket for rotatably mounting a spherical ball. The spherical ball can discharge the fluid product by rotation. The sidewall includes at least two through feed openings that allow filling of the internal longitudinal cavity with the fluid product when the applying member is dipped in the receptacle. A portion of the spherical ball protrudes from the ball socket beyond the open distal end of the applying member.

Abstract: A packaging and applicator device comprising a container containing a liquid composition for application, an applicator capable of being fastened removably on the container, and a corrector mounted at one end of the applicator. The applicator includes a rod, an applicator endpiece at a distal end of the rod, and a handle member connected to a proximal end of the rod. The applicator endpiece is made of a felt tip that can be impregnated with the composition contained in the container, and wherein the applicator endpiece is used for applying eyeliner. The packaging and applicator device further includes a filter adjacent to the applicator endpiece to supply the liquid composition to the applicator endpiece during application.

Abstract: An applicator head intended to be associated with a cosmetic dispensing package for dispensing and applying a fluid product. The applicator head includes a first applicator member and a second applicator member coupled to one side of the first applicator member. The second applicator member made of a material capable of holding and retaining a thermal charge. An upper surface of the applicator head defines an applicator surface adapted to apply and dispense the fluid product. The applicator surface is angled with respect to a longitudinal axis of the applicator head. A recessed concavity is formed on the applicator surface and a discharge opening is disposed within the recessed concavity. A first portion of the recessed concavity lies on the first applicator member and a second portion of the recessed concavity lies on the second applicator member.

Abstract: A water supply device (10) and a tube connector structure (2) thereof, which are used for an electronic device (100) having a water inlet (101) and a water outlet (102), are disclosed. The tube connector structure (2) includes a connecting plate (21) and two tube connector plugs (22) passing through and fixed to the connecting plate (21). One of the tube connector plugs (22) is connected with the water inlet (101), and the other one of the tube connector plugs (22) is connected with the water outlet (102). Therefore, advantages of rapid connection and disconnection between the water supply device (10) and the tube connector structure (2) and saving time and labor in assembling may be accomplished.

Abstract: A RRAM and its manufacturing method are provided. The RRAM includes an interlayer dielectric layer, a first bottom contact structure, and a second bottom contact structure formed on a substrate. A first memory cell is formed on the first bottom contact structure. The first memory cell includes a first bottom electrode layer which includes a first conductive region. A pattern in which the first conductive region is vertically projected on the first bottom contact structure is a first projection pattern. A second memory cell is formed on the second bottom contact structure. The second memory cell includes a second bottom electrode layer which includes a second conductive region. A pattern in which the second conductive region is vertically projected on the second bottom contact structure is a second projection pattern. The second projection pattern is different from the first projection pattern.

Abstract: A manufacturing method of a memory device are provided. The method includes following steps. A gate stacking structure is formed over a substrate. A first insulating layer, a second insulating layer and a mask material layer are sequentially formed over the substrate to cover the gate stacking structure. An ion implantation process is performed on the mask material layer to form a doped portion in the mask material layer. The doped portion caps on a top portion of the gate stacking structure. A first patterning process is performed on the mask material layer using the doped portion as a shadow mask to remove a bottom portion of the mask material layer extending along a surface of the substrate. A second patterning process is performed to remove the doped portion of the mask material layer and an exposed bottom portion of the second insulating layer surrounding the gate stacking structure.

Abstract: The disclosure features isolated polynucleotides, such as mRNAs, encoding a polypeptide that disrupts immune cell activity, such as T cell or B cell activity, including mRNAs comprising one or more modified nucleobase. The immune cell disruptor polynucleotides encode a polypeptide that comprises a first domain that mediates association of the polypeptide with an immune cell component and a second domain that mediates inhibition of immune cell activity when the polypeptide is expressed in the immune cell. The disclosure also features methods of using the same, for example, for inhibiting immune responses when administered to a subject, such as to inhibit autoimmune reactions.

Abstract: A memory device and a manufacturing method thereof are provided. The memory device includes a gate stacking structure, a first insulating layer, a second insulating layer and a first spacer. The gate stacking structure is disposed over a substrate. The first insulating layer covers a top surface and a sidewall of the gate stacking structure. The second insulating layer covers a surface of the first insulating layer. A top corner region of the gate stacking structure is covered by the first and second insulating layers. The first spacer is located on the sidewall of the gate stacking structure, and covers a surface of the second insulating layer. A topmost end of the first spacer is lower than a topmost surface of the second insulating layer.

Abstract: A cosmetic package for dispensing and applying a fluid product, the cosmetic package comprises a container for accommodating the fluid product and an applicator head coupled to the container. The applicator head comprises a plurality of ball members, an upper plate, a lower plate, and a connector. The lower plate supports the plurality of the ball members on an upper surface thereof. The upper plate covers the lower plate such that a part of the plurality of ball members is exposed to the outside through a plurality of openings of the upper plate. A duct of the upper plate extends through the lower plate and connects to an internal duct of the connector so that the fluid product can move from the internal duct of the connector to the upper plate and can be dispensed through a dispensing orifice formed in the upper plate.

Abstract: A method of manufacturing a memory structure including the following steps is provided. A spacer layer is formed on sidewalls of gate stack structures. A protective material layer covering the spacer layer and the gate stack structures is formed. A mask material layer is formed on the protective material layer. There is a void located in the mask material layer between two adjacent gate stack structures. A first distance is between a top of the protective material layer and a top of the mask material layer. A second distance is between a top of the void and a top of the mask material layer above the void. A third distance is between a bottom of the void and a bottom of the mask material layer below the void. The first distance is greater than a sum of the second and third distances.

Abstract: A learning method and a learning device for visual odometry based on an ORB feature of an image sequence are provided. The learning method includes: recording images, and constituting an original data set by means of the plurality of obtained images; performing ORB feature extraction on the images in the original data set to realize extraction of first key features; performing feature extraction and matching on continuous images in the original data set by means of a convolutional neural network, and extracting rich second key features from the sequential images; and inputting the first key features and the second key features extracted from the original data set into a multi-layer long-short-term memory network for training and learning, and generating and outputting estimation of a visual odometer. Rich first key features are extracted from an image sequence, and then a tracking algorithm is used for tracking the features in continuous frames.

Abstract: A cosmetic package comprising a roller for discharging a powder product. The cosmetic package comprises an outer cap, an inner cap, an insert, the roller, a container, and a base plug. The container has an open bottom end which is closed by the base plug. The insert is mounted within the container above a cosmetics accommodating space of the container. A bottom surface of the insert includes two support members for rotatably accommodating two axle projections of the roller such that at least a portion of the roller is disposed rotatably within the cosmetics accommodating space of the container and another portion of the roller extending outside the cosmetics accommodating space from an aperture located at a bottom end of the insert. The inner cap forms a tight seal with the insert and the roller to prevent leakage of powder product from the container.

Abstract: A cosmetic package comprising a roller for discharging a powder product. The cosmetic package comprises an outer cap, an inner cap, an insert, the roller, a container, and a base plug. The container has an open bottom end which is closed by the base plug. The insert is mounted within the container above a cosmetics accommodating space of the container. A bottom surface of the insert includes two support members for rotatably accommodating two axle projections of the roller such that at least a portion of the roller is disposed rotatably within the cosmetics accommodating space of the container and another portion of the roller extending outside the cosmetics accommodating space from an aperture located at a bottom end of the insert. The inner cap forms a tight seal with the insert and the roller to prevent leakage of powder product from the container.

Abstract: A dispenser for dispensing a liquid product, the dispenser comprising a housing, a pump assembly, a dispensing head, and an inner container. The inner container accommodates the liquid product and is configured to be inserted into a cavity of the housing. The inner container is replaceable and detachably connected to the housing such that the housing, the pump assembly, and the dispensing head can be retained for reuse while the inner container can be replaced with a new inner container. A protrusion is provided on an underside of the inner container that a user can grip to rotate the inner container in a clockwise or anticlockwise direction to disengage the inner container from the housing.

Abstract: A dispenser for dispensing a liquid product, the dispenser comprising an inner case, a pump assembly, a dispensing head, a collar, a dialer, and an outer case. The inner case accommodates the liquid product. The outer case removably houses the inner case in a hollow cavity formed therein. The dialer is rotatable on an outer surface of the outer case. The dialer is detachably coupled with the inner case which allows the inner case to be housed within the outer case in a removable manner. The dialer is rotated circumferentially on an outer peripheral surface of the outer case for engaging and disengages the inner case. The collar is designed to house the pump assembly and is engaged on an open upper end of the outer case. The dispensing head is coupled to the pump assembly and comprises a nozzle to dispense the pumped liquid product when actuated.

Abstract: The present invention describes methods of treating, preventing, reducing the likelihood of having, reducing the severity of and/or slowing the progression of a medical condition related to ischemia/reperfusion in a subject using GJA1-20k as a therapeutic agent. The invention further provides a method of protecting a cell from metabolic stress, using GJA1-20k. The invention also provides for a composition and/or gene expression vector comprising GJA1-20k.

Abstract: A cosmetic applicator for applying a product including a cosmetic, care or pharmaceutical product onto the keratinous substrate. The cosmetic applicator comprises an applying member and a shank. The applying member comprises a first application face and a second application face opposite to the first application face, a first peripheral edge, and a second peripheral edge opposite the first peripheral edge. The applying member has a plurality of bulged portions on the second application face and a corresponding plurality of depressed portions on the first application face. The plurality of bulged portions extend from the first peripheral edge towards a central longitudinal axis of the applying member but do not extend up to the second peripheral edge. Each of the plurality of bulged portions has an arched structure, and each of the plurality of depressed portion has a concave bowl structure.