Chewable Tablet Or Wafer Patents (Class 424/441)
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Patent number: 7544377Abstract: A chewable oral composition for oral cleansing, breath freshening, and antimicrobial benefits includes fast release Magnolia Bark Extract in combination with a surface active agent. The effectiveness of Magnolia Bark Extract in inhibiting biofilm formation in the oral cavity is increased by a synergistic combination of the rapidly released Magnolia Bark Extract with a surface active agent in a chewable oral cavity delivery agent, such as chewing gum, chewable candy, and a soft tablet. The fast release of the antimicrobial agents is effectuated by encapsulation or coating of the oral cavity delivery agent.Type: GrantFiled: November 17, 2006Date of Patent: June 9, 2009Assignee: GIC Innovations CompanyInventors: Michael W. J. Dodds, James Roy Maxwell, Michael J. Greenberg, Minmin Tian
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Patent number: 7521072Abstract: A delivery system and method for delivering soluble dietary fibers in a chewable tablet form which is palatable and demonstrates a high degree of consumer acceptability.Type: GrantFiled: August 19, 2004Date of Patent: April 21, 2009Assignee: CNS, Inc.Inventor: Jerome J. Licari
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Publication number: 20090092658Abstract: The present invention relates to combinations of a proton pump inhibiting agent and at least one buffering agent that have been found to possess improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties.Type: ApplicationFiled: October 5, 2007Publication date: April 9, 2009Inventors: Warren Hall, Laura Weston, Kay Olmstead, Laura Gallo, Craig Bowe
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Patent number: 7494980Abstract: A method of preventing biofilm formation in an environment including the steps of administering to the environment an effective amount of a peptide having the amino acid sequence NH2-lys-lys-val-val-phe-lys-val-lys-phe-lys-CONH2 [SEQ ID NO: 1] The method is useful in preventing the formation of biofilms in various environments including a home, workplace, laboratory, industrial environment, aquatic environment, animal body or human body. A method of inhibiting the growth of oral microorganisms including the steps of administering to an oral environment an effective amount of a peptide having the amino acid sequence NH2-lys-val-val-phe-lys-val-lys-phe-lys-CONH2 [SEQ ID NO: 1].Type: GrantFiled: March 9, 2004Date of Patent: February 24, 2009Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Kai P Leung, Sean P Concannon
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Patent number: 7491406Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, methyl salicylate, eucalyptol and menthol. The edible films are effective at killing the plaque-producing germs that cause dental plaque, gingivitis and bad breath. The film can also contain pharmaceutically active agents. Methods for producing the films are also disclosed.Type: GrantFiled: October 13, 2005Date of Patent: February 17, 2009Assignee: McNeil-PPC, Inc.Inventors: Sau-Hung Spence Leung, Robert S. Leone, Lori D. Kumar, Neema Kulkarni, Albert F. Sorg
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Patent number: 7485319Abstract: The present invention is a solid dosage form of a doxycycline metal complex. The present invention also includes a process for making a doxycycline metal complex in a solid dosage form. The process comprises the steps of (i) providing an aqueous solution of doxycycline or a physiologically acceptable salt thereof; (ii) admixing a metal salt with the aqueous solution; (iii) admixing a base to increase the pH of the aqueous solution, thereby forming a suspension of doxycycline metal; and (iv) drying the suspension, thereby forming a dry granulation of doxycycline metal complex.Type: GrantFiled: July 22, 2004Date of Patent: February 3, 2009Assignee: Warner Chilcott Company, Inc.Inventors: Tina deVries, Lynn Gold
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Patent number: 7482031Abstract: An anti-cough, anti-tussive, and throat soothing synergistic herbal formulation comprising of an extract of Piper cubeba, Glycyrrhiza glabra, Acorus calamus Alpinia galanga, Zingiber officinale and pharmaceutically acceptable additives as a syrup, lozenges or chewable tablets for preventing cracking of voice, dryness of mouth and toning of voice, vocal cord; the present invention also provides a method of preparation of this formulation.Type: GrantFiled: June 9, 2003Date of Patent: January 27, 2009Assignee: Council of Scientific & Industrial ResearchInventors: Palpu Pushpangadan, Govindarajan Raghavan, Vijayakumar Madhavan, Shanta Mehrotra, Rawat Ajay Kumar Singh, Chandana Venkateshwara Rao
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Publication number: 20080286341Abstract: Coated oral dosage forms for the delivery of nicotine in any form to a subject by rapid intraoral delivery of nicotine comprising at least one core, nicotine in any form and/or a nicotine mimicking agent, at least one coating layer and optionally at least one or more other additives, wherein said at last one coating layer is buffered, whereby is used at least one amino acid as buffering agent. Also contemplated are a method for the delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as a method for producing said coated product and use of the same for obtaining a rapid intraoral uptake of nicotine.Type: ApplicationFiled: May 16, 2007Publication date: November 20, 2008Inventors: Sven-Borje Andersson, Gunnar Bergengren, Bengt Bosson, Andreas Hugerth, Fredrik Nicklasson, Roland Olsson
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Publication number: 20080286340Abstract: A pharmaceutical oral formulation for delivering nicotine in any form to a subject by transmucosal uptake in the oral cavity comprising nicotine in any form, wherein said oral formulation is buffered with at least one amino acid, preferably at least one endogenous amino acid. Also contemplated is a method for the oral delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as methods for manufacturing the oral formulation, the use of said oral formulation for obtaining transmucosal uptake of nicotine in the oral cavity of a subject, and use of nicotine for the production of an oral formulation as per above for the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.Type: ApplicationFiled: May 16, 2007Publication date: November 20, 2008Inventors: Sven-Borje Andersson, Gunnar Bergengren, Bengt Bosson, Andreas Hugerth, Fredrik Nicklasson, Roland Olsson
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Patent number: 7452916Abstract: Endothelial nitric oxide production is enhanced by administration of arginine or lysine as a dietary supplement. Enhanced nitric oxide production from arginine supplementation improves vascular function and structure. Additional compounds may be administered with arginine or lysine to further enhance nitric oxide activity, including calcium, vitamin B6, vitamin B12, vitamin C, vitamin B, coenzyme Q, carotene, or glutathione.Type: GrantFiled: December 22, 2004Date of Patent: November 18, 2008Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventor: John P. Cooke
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Publication number: 20080254101Abstract: The present invention provides novel compositions for the delivery of pilocarpine or a pharmaceutically acceptable salt thereof across the oral mucosa, preferably across the buccal mucosa. In particular, the buffer systems in the compositions of the present invention contain an amount of a strong base that is less than the amount of a weak base, thereby increasing the stability of compositions such as chewing gum compositions and raising the pH of saliva to a pH greater than about 7.5 to facilitate the substantially complete conversion of pilocarpine from its ionized to its un-ionized form. Methods for using the compositions of the present invention for treating conditions such as dry mouth are also provided.Type: ApplicationFiled: June 25, 2008Publication date: October 16, 2008Inventor: Nikhilesh N. Singh
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Patent number: 7396546Abstract: An anti-microbial composition is provided. The anti-microbial composition includes a first ingredient obtainable from ginger, a second ingredient obtainable from green tea, an optional third ingredient available from turmeric, and, optionally, an acceptable carrier. Also provided are methods of reducing, treating or preventing at least one symptom or adverse effect of microbial infection in a patient. The methods include the step of administering to the patient prior to expected exposure to a microbe, concurrently with exposure to a microbe, or after exposure to a microbe, an effective amount of a composition of the invention.Type: GrantFiled: February 6, 2003Date of Patent: July 8, 2008Assignee: The Quigley CorporationInventor: Richard A. Rosenbloom
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Publication number: 20080160067Abstract: This document relates to formulations for combating bacterial infections in animals which provide for improved long-acting oral and injectable formulations for systemic delivery of antibiotics, which are designed to achieve high bioavailability.Type: ApplicationFiled: September 5, 2007Publication date: July 3, 2008Inventors: Albert Boeckh, Mark D. Soll, Monica Tejwani-Motwani, Robert P. Waranis, Fangjun Wu
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Publication number: 20080138384Abstract: Disclosed is a hair growth stimulant for oral use comprising at least one member selected from the group consisting of plants of the genus Orthosiphon in the family Lamiaceae, plants of the genus Vitex L. in the family Verbenaceae, and extracts thereof; and a food comprising the hair growth stimulant for oral use.Type: ApplicationFiled: February 12, 2008Publication date: June 12, 2008Inventors: Kouichi Nakaoji, Masahiro Matsuura, Naoko Hayashi, Toyoyuki Nishi
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Publication number: 20080113005Abstract: The present invention relates to a composition comprising extracts of Gramineae plant that improves cell viability under hypoxic conditions by inhibiting apoptosis. Thus, the extract of Triticum aestivum L., one of the Gramineae plant, of the present invention, in particular, prevents damage of brain, heart and kidney in animal models of ischemic diseases, and it also improves memory in an animal model of Alzheimer's disease. Therefore, a composition comprising extracts of Gramineae can be used as therapeutic agents or health care foods for preventing and treating ischemic diseases and degenerative brain diseases.Type: ApplicationFiled: January 4, 2006Publication date: May 15, 2008Applicants: HYPOXI CO., LTD., SUN MOK INSTITUTE EDUCATION FOUNDATIONInventors: Jong Won Lee, Ki-Chul Hwang, Hyung Soo Han, Sun Ha Lim, Hyeong-Kyu Lee, Sang Hyuk Lee, Kyu Won Kim, Hyung Oh Jun, Hyun Jeong Kim, In-Seon Lee, Chae Ha Yang
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Publication number: 20080113004Abstract: Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms.Type: ApplicationFiled: November 7, 2007Publication date: May 15, 2008Inventor: Lawrence R. Bernstein
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Patent number: 7351438Abstract: The invention is a chewing gum formulation in powder form, a process for producing it, and a chewing gum in tablet produced by direct compression of a the chewing gum formulation in powder form that is characterized by a chewability that remains unchanged throughout the chewing period.Type: GrantFiled: May 13, 2003Date of Patent: April 1, 2008Assignee: Gum Base Co. S.p.A.Inventors: Giuseppe Sozzi, Fabio Allasia
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Publication number: 20070274927Abstract: A slow-dissolving troche with polyol molecules is disclosed. It may be an adherent troche, preferably adhered to teeth or gums or cheek with acacia gum, or a lollipop or child's pacifier. Consumers are instructed to use the troches at the end of each day and after each meal, at least four times per day to benefit oral health, particularly caries, gingivitis, periodontitis, ear infections, sinus infections, halitosis and risk of Streptococcus mutans infecting their blood from their mouths. The polyol molecules are preferably xylitol. The troches may be made with a bi-layer tablet press rounded on one side and flat on the other, preferably using acacia gum in the flat side layer for adhesion.Type: ApplicationFiled: May 4, 2007Publication date: November 29, 2007Inventors: Jeffrey T. Haley, Steven Edwards
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Publication number: 20070269492Abstract: Coated oral dosage forms for the delivery of nicotine in any form to a subject by rapid intraoral delivery of nicotine comprising at least one core, nicotine in any form and/or a nicotine mimicking agent, at least one coating layer and optionally at least one or more other additives, wherein said at last one coating layer is buffered, whereby is used at least trometamol as buffering agent. Also contemplated is a method for the delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as a method for producing said coated product and the use of the same for obtaining a rapid intraoral uptake of nicotine.Type: ApplicationFiled: June 1, 2006Publication date: November 22, 2007Inventors: Per Steen, Darek Dymitrowicz, Asa Waltermo, Roland Olsson, Katarina Lindell
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Patent number: 7258868Abstract: Substrates are provided for use in a heating and/or blowing device that dispenses volatile material. The substrates are a porous medium (such as porous ceramic) having their interior pores coated by a polymeric material (such as a polysiloxane). The substrate is impregnated with a volatile such as pyrethrum. The substrate is less susceptible to clogging. Also disclosed are methods of making those substrates in which the polymeric material is wicked into the substrate with a volatile solvent.Type: GrantFiled: January 15, 2004Date of Patent: August 21, 2007Assignee: S.C. Johnson & Son, Inc.Inventors: Kenneth J. Welch, Robert R. Emmrich, Michael J. Aulozzi
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Patent number: 7226620Abstract: A compressible tricalcium phosphate agglomerate comprises tricalcium phosphate particles, each having an outer surface, and a binder comprising a polyvinylpyrollidone, carrageenan, or a guar gum, supported on at least a portion of the outer surface of at least a portion of the tricalcium phosphate particles.Type: GrantFiled: May 4, 2005Date of Patent: June 5, 2007Assignee: Rhodia Inc.Inventors: Lewis Roe Hendricks, Jill Marie Jobbins, Wayne Camarco
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Patent number: 7223421Abstract: Taste masked particles and chewable tablets made therefrom are disclosed. The taste masked particles comprise a core containing an active ingredient and a polymeric coating covering said core, said coating comprising a mixture of a) an enteric polymer; and b) an insoluble film forming polymer, the surface of said particle being free of active ingredient. The chewable tablets provide immediate release of the active ingredient.Type: GrantFiled: June 8, 2001Date of Patent: May 29, 2007Assignee: McNeil-PPC, Inc.Inventors: Daniel McTeigue, Narenda Parikh, David W. Wynn, Ravivaj S. Pillai
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Patent number: 7208186Abstract: The present invention involves a novel chewing gum formulation and a method of making the same. The chewing gum formulation is used to form a final chewing gum composition which contains an active ingredient which is released from the chewing gum as the gum is masticated in the mouth of the user. The chewing gum made from the chewing gum composition of the present invention is initially a compressed body, such as a tablet, which quickly dissociates into a multiplicity of small pieces upon initial chewing followed by a reformation of the pieces into a coherent mass of chewing gum after a few seconds of chewing. Both the chewing gum formulation and the chewing gum composition are in the form of a free-flowing particulate which is capable of being directly compressed at high speed by a standard tableting machine into chewing gum tablets.Type: GrantFiled: April 24, 2003Date of Patent: April 24, 2007Assignee: SPI Pharma, Inc.Inventors: Gary T. Norman, Arun F. Amin
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Patent number: 7166294Abstract: The present invention provides a method for controlling ectoparasites of small rodents, thereby preventing the transmission of diseases by arthropod vectors.Type: GrantFiled: October 28, 2002Date of Patent: January 23, 2007Assignees: Centers for Disease Control and Prevention, Aventis CropScience S.A.Inventors: Gary O. Maupin, Marc C. Dolan, Patrick D. Lowder
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Patent number: 7125560Abstract: The invention is directed to a pharmaceutical composition of topiramate, an anticonvulsant which is useful for treating epilepsy. More specifically, the present invention provides a solid dosage formulation of topiramate intended primarily for use by pediatric patients, or for patients who have difficulty swallowing tablets. Processes for preparing the pharmaceutical composition are also described.Type: GrantFiled: December 30, 2003Date of Patent: October 24, 2006Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Madhav S. Thakur, Pramod M. Kotwal, Irwin S. Gibbs
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Patent number: 7118765Abstract: The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.Type: GrantFiled: October 18, 2002Date of Patent: October 10, 2006Assignee: SPI Pharma, Inc.Inventors: Gary Telfer Norman, Kalyan S. Nuguru, Arun F. Amin, Sarath Chandar
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Patent number: 7105176Abstract: A process is described for producing solid preparations of at least one water-soluble, sparingly water-soluble or water-insoluble active compound suitable for the food and animal feed sectors or for pharmaceutical and cosmetic applications. In addition, the invention relates to oily suspensions in which these preparations are present as disperse phase, and to the use of these preparations as additive to animal feeds, foods, pharmaceuticals and cosmetic preparations.Type: GrantFiled: November 19, 2001Date of Patent: September 12, 2006Assignee: BASF AktiengesellschaftInventors: Helmut Auweter, Heribert Bohn, Erik Lüddecke, Willy Hinz, Frank Runge, Angelika-Maria Pfeiffer
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Patent number: 7101579Abstract: The present invention provides a chewing gum composition containing an active ingredient. The preferred chewing gum composition comprises a plurality of granules comprising a mixture of a powdered chewing gum base and a selected amount of a powdered active ingredient, said powdered chewing gum base and powdered active ingredient being mixed together within said granules. Additives may be mixed in the granules or may coat the granules. The preferred form is a tablet containing a controlled dosage form of the active ingredient.Type: GrantFiled: March 8, 2004Date of Patent: September 5, 2006Assignee: Deseret Laboratories, Inc.Inventors: Narayan K. Athanikar, Scott A. Gubler
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Patent number: 7078052Abstract: Methods and chewing gums for delivering a medicament or agent to an individual are provided. The chewing gum includes a medicament or agent. The medicament or agent is present within the chewing gum composition (the water soluble portion and/or insoluble base portion). It has been found that by chewing the gum, the medicament or agent is released from the chewing gum. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.Type: GrantFiled: December 22, 2003Date of Patent: July 18, 2006Assignee: Wm. Wrigley Jr. CompanyInventors: Ronald L. Ream, Christine L. Corriveau, William J. Wokas, Thomas M. Tongue, Jr., Michael J. Greenberg
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Patent number: 7078053Abstract: Fumaric acid is added in amounts sufficient to reduce the burn sensation commonly associated with propionic acid derivatives.Type: GrantFiled: August 5, 2003Date of Patent: July 18, 2006Assignee: McNeil-PPC, Inc.Inventors: Frank J. Bunick, Feng Lin
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Patent number: 7041311Abstract: The present invention is directed to products that promote saliva generation in the mouth through the use of various food grade acceptable acids. The products that enhance saliva production are preferably foods that are consumed in the mouth over a period of time of a minute or longer such as chewing gums, breath films, toothpaste and lozenges.Type: GrantFiled: February 28, 2003Date of Patent: May 9, 2006Assignee: International Flavors & Fragrances Inc.Inventors: Brian T. Grainger, Derek Richard Farley, Ana Paula Ventura da Costa Lopes
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Patent number: 7029699Abstract: The present invention relates to a compressed, chewable tablet containing at least one active ingredient, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and compressed into convex-shaped tablet having a hardness of about 2 to about 11 kp/cm2 and friability less than 1%.Type: GrantFiled: August 22, 2002Date of Patent: April 18, 2006Inventors: Ronni L. Robinson, James R. Damon, James R. Mossop, Michael D. Palmer
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Patent number: 7018630Abstract: A Bacillus natto culture is treated with chitosan, and then filtered, concentrated, and dried. According to this method, a Bacillus natto culture extract containing nattokinase and 1 ?g or less of vitamin K2/g dry weight is obtained.Type: GrantFiled: January 22, 2004Date of Patent: March 28, 2006Assignee: Japan Bio Science Laboratories, Inc.Inventor: Shinsaku Takaoka
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Patent number: 7014862Abstract: Oral compositions, suitable for chewing, comprising a gel-forming polysaccharide isolated from psyllium seed husks and an excipient that is fast dissolving in the oral cavity, provide good aesthetics and acceptable mouthfeel as perceived by the consumer. The oral compositions are useful for normalizing bowel function, reducing human serum cholesterol levels and treatment of other gastrointestinal disorders.Type: GrantFiled: February 18, 2003Date of Patent: March 21, 2006Assignee: The Procter & Gamble CompanyInventors: Graham John Myatt, Christopher Neil Harrison, Paul Alfred Cimiluca, Theresa Marie Kajs
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Patent number: 6962715Abstract: A method of manufacturing a bioactive fluid dose on an ingestible sheet, comprising the steps of advancing the ingestible sheet to a dispense position, and activating a fluid ejector to dispense essentially a drop of a bioactive fluid onto the ingestible sheet.Type: GrantFiled: October 24, 2001Date of Patent: November 8, 2005Assignee: Hewlett-Packard Development Company, L.P.Inventors: Brian Craig Lee, Steven W. Steinfield, Winthrop D. Childers, Mark A. Van Veen, Mohammad M. Samii
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Patent number: 6953588Abstract: This invention is directed to a multi-vitamin and mineral supplement tailored to men and post-menopausal women, pre-menopausal women, and athletes which supplies the right amount of the right micronutrients at the right time to assure adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to lifestyle factors and common inadequate dietary patterns. The multi-vitamin and mineral supplement is comprised of vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin B12, biotin, pantothenic acid, iron, iodine, magnesium, zinc, selenium, copper, chromium, potassium, choline, lycopene, and co-enzyme Q-10.Type: GrantFiled: October 25, 2002Date of Patent: October 11, 2005Assignee: Cooper Concepts, Inc.Inventors: Kenneth H. Cooper, Ishwarlal Jialal, Scott Montgomery Grundy, Walter Churchill Willett, Jacob Selhub
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Patent number: 6939560Abstract: The present invention provides a pharmaceutical composition which is substantially free of unpleasant tastes and orally administrable which comprises: (a) an active medicament, (b) an inner coating layer comprising an oil substance having a melting point at a range of from about 50° C. to about 100° C., (c) an outer coating layer comprising at least a polymeric substance.Type: GrantFiled: December 15, 2000Date of Patent: September 6, 2005Assignee: Pharmacia & Upjohn CompanyInventors: Robert W. Shen, Gerald A. Walter
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Patent number: 6932979Abstract: The soluble, rubber-containing, coated chewable tablet contains chewable components, syrup components and fat or wax components and optionally fillers. It can be prepared by a process in which pulverulent chewable components are mixed with the molten fat or wax components. The mixture, with the addition of at least one syrup component, then becomes a crumbly material, which is then cooled to below 0° C., then milled to a particle size of not more than 5 mm and, after cooling to below 10° C., compressed to give tablets which are coated in a known manner. The finished product—due to compression of the cooled granules—presumably has a partially granular structure in which the moisture has been initially immobilized by the low temperature. After compression, this moisture becomes mobile as a result of heating (in particular during the coating process) and migrates or diffuses—initially at the surface—into the water-soluble ingredients present.Type: GrantFiled: April 7, 2003Date of Patent: August 23, 2005Assignee: Dr. Gergely & Co.Inventors: Gerhard Gergely, Irmgard Gergely, Thomas Gergely
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Patent number: 6923988Abstract: The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals and diagnostic agents.Type: GrantFiled: May 1, 2003Date of Patent: August 2, 2005Assignee: Lipocine, Inc.Inventors: Mahesh V. Patel, Feng-Jing Chen
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Patent number: 6911214Abstract: A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof.Type: GrantFiled: September 4, 2001Date of Patent: June 28, 2005Assignee: Abbott LaboratoriesInventors: Laman Alani, Donald P. Gauwitz, Dilip Kaul, John M. Lipari, Soumojeet Ghosh, Kennan C. Marsh, Richard H. Whelan, Vanik D. Petrossian
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Patent number: 6911215Abstract: The invention is a dietary supplement for animals, especially dogs, for treating arthritis and joint discomfort. A biscuit form of the supplement may be in the form of a conventional carrier composition of, for example, typical dog biscuit materials including cereal grains, vegetables or animal meat, fat and by-products. Typically, the biscuit contains about 89-97 weight percent (wt. %) of the conventional carrier composition. Optional vitamins and minerals may also be added to the carrier material, typically in about the 1-5 wt. % range. Importantly, the biscuit of the present invention contains about 3-7 wt. % of an arthritis-treating combination, namely, glucosamine sulfate, vitamin C and an array of intracellular ions namely potassium, sodium and iodine. The glucosamine component is present by weight at approximately the same level as the vitamin C, and at approximately 10 (ten) times the level of the sum of the above-named intracellular ions.Type: GrantFiled: November 18, 2002Date of Patent: June 28, 2005Assignee: Nutri-Vet, LLCInventor: Andrew Myers
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Patent number: 6902738Abstract: Topical oral dosage forms containing bismuth compounds are described, which are useful for treating H. pylori and other bacterial infections that cause gastrointestinal disorders and halitosis, as well as for treating ocular and dermal wounds. Methods of employing topical oral dosage forms for treating bacterial infections that cause gastrointestinal disorders and halitosis, and for treating ocular and dermal wounds, are also described.Type: GrantFiled: March 19, 2002Date of Patent: June 7, 2005Assignee: Josman Laboratories, Inc.Inventors: Scott A. Gubler, Narayan K. Athanikar
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Nutritional composition, methods of producing said composition and methods of using said composition
Patent number: 6899891Abstract: Nutritional compositions comprising at least one of aloe vera, hydrolyzed collagen, garcinia cambogia, chromium polynicotinate, chromium picolinate, chromium cruciferate, conjugated linoleic acid, fiber and natural amino acids are disclosed. Nutritional compositions comprising aloe vera, hydrolyzed collagen, garcinia cambogia tea, fenugreek tea, coleus forskohli tea, chromium polynicotinate, chromium picolinate, chromium cruciferate, conjugated linoleic acid, fiber and natural amino acids are also disclosed. Methods for preparing and using these compositions are additionally provided.Type: GrantFiled: November 29, 2001Date of Patent: May 31, 2005Inventor: Harry J. Siskind -
Patent number: 6878386Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.Type: GrantFiled: April 6, 2000Date of Patent: April 12, 2005Assignee: Beecham Pharmaceuticals (Pte) LimitedInventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
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Patent number: 6872405Abstract: The present invention relates to a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent, which is obtained by uniformly mixing the saccharide with a low melting point in the tablet so that a bridge will be formed between said drug and/or said diluent particles by the product of melting and then solidification of this saccharide with a low melting point.Type: GrantFiled: May 8, 2002Date of Patent: March 29, 2005Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yuuki Takaishi, Takao Mizumoto, Yoshinori Masuda
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Patent number: 6869614Abstract: A gum, lollipop and lozenge having at least two separate components, with at least one of such components containing amounts of herbal, medicinal and/or mineral elements or combinations thereof.Type: GrantFiled: August 21, 2003Date of Patent: March 22, 2005Inventor: Jack Barreca
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Patent number: 6846495Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.Type: GrantFiled: December 20, 1999Date of Patent: January 25, 2005Assignee: The Procter & Gamble CompanyInventors: Douglas Joseph Dobrozsi, Jerry William Hayes, II, Kishor Jivanlal Desai, Brian James Robbins
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Patent number: 6827945Abstract: A nutritional supplement for providing, and for promoting the health of salivary glands and/or supporting normal or healthy swallowing includes ingredients obtainable from turmeric, ginger, and horseradish. The nutritional supplement may also be used to treat symptoms such as symptoms of a common cold, sore throat, congestion, mucositis, laryngitis, mucous membrane inflammation and sialorrhea, as well as inflammation and viral infectin, or to inhibit or exterminate a virus. This nutritional supplement can be orally administered a person. The nutritional supplement may further include optional ingredients such as ingredients obtainable from slippery elm bark powder and green tea, as well as other optional ingredients. This nutritional supplement may further include a pharmaceutically acceptable carrier for oral administration.Type: GrantFiled: April 23, 2003Date of Patent: December 7, 2004Assignee: The Quigley CorporationInventor: Richard A. Rosenbloom
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Patent number: 6814978Abstract: The invention relates to a process for preparing a soft tablet capable of being chewed or disintegrated in the oral cavity. The tablet is prepared by forming a tablet having a friability of less than about 2% from a mixture comprising a pharmaceutically active ingredient, an excipient in the form of a hydrate, and a water-swellable excipient, and then applying sufficient energy, preferably in the form of heat, to the tablet for a sufficient time to decrease the hardness of the tablet by at least about 20%.Type: GrantFiled: December 29, 2000Date of Patent: November 9, 2004Assignee: McNeil-PPC, Inc.Inventors: Frank J. Bunick, Joseph Luber
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Patent number: 6790453Abstract: Encapsulation compositions in which an encapsulate (A) is encapsulated in a matrix (B) may be prepared by: (i) mixing matrix (B) with a liquid plasticizer and encapsulate (A) in an extruder, to obtain a melted mixture of encapsulate (A) and matrix (B); and (ii) extruding the melted mixture, to obtain an extruded mixture.Type: GrantFiled: March 14, 2002Date of Patent: September 14, 2004Assignee: McCormick & Company, Inc.Inventors: Michael A. Porzio, Dmitriy Zasypkin