Chewable Tablet Or Wafer Patents (Class 424/441)
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Patent number: 6783773Abstract: Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.Type: GrantFiled: October 5, 2001Date of Patent: August 31, 2004Assignee: Beecham Pharmaceuticals (Pte) LimitedInventors: Kevin H. Storm, Creighton P. Conley, John A. Roush
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Patent number: 6780438Abstract: A dietary supplement for mammalian consumption, and particularly human consumption, for the purpose of stimulating the immune system, inhibiting infection and increasing tissue repair and healing. Comprising colostrum, lactoferrin, and with modified citrus pectin as an optional component, the dietary supplement is administered in ‘mucosal delivery format’: a dosage form that promotes effective absorption through the lining of the oral cavity.Type: GrantFiled: July 31, 2002Date of Patent: August 24, 2004Assignee: Lactoferrin Products CompanyInventors: Marcus B. Gohlke, Richard H. Cockrum
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Patent number: 6773716Abstract: Methods and products for delivering a medicament or agent to an individual are provided. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a center comprising a gum base. By chewing the product, the medicament or agent is released from the product. Continuing to chew the product creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.Type: GrantFiled: November 13, 2001Date of Patent: August 10, 2004Assignee: Wm. Wrigley Jr. CompanyInventors: Ronald L. Ream, Michael J. Greenberg, William J. Wokas, Christine L. Corriveau
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Patent number: 6767567Abstract: The invention relates mainly to an element suitable for being ingested, the element including at least one air-passing channel making it possible to avoid choking in the event of being swallowed the wrong way. The present invention applies to the food industry and also to the pharmaceuticals industry.Type: GrantFiled: February 22, 2001Date of Patent: July 27, 2004Inventors: Philippe Douaire, Sandrine Vincensini
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Patent number: 6761911Abstract: The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in animals. Populations of enteropathogenic bacteria may be substantially reduced or eliminated by treatment of animals with an effective amount of the compound Xm(ClO3)n, wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0. The compounds may be administered orally, providing a reduction in the populations of the enteropathogenic bacteria in the alimentary tract of the animal, or they may be applied externally onto the animal to reduce the populations of any such bacteria which may be present as contaminants on the surface of the animal. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic Escherichia coli, and Clostridia species.Type: GrantFiled: October 3, 2002Date of Patent: July 13, 2004Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Robin C. Anderson, David J. Nisbet, Larry H. Stanker
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Patent number: 6761903Abstract: The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a carrier, where the carrier is formed from a combination of a triglyceride and at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous medium, the carrier forms a clear, aqueous dispersion of the triglyceride and surfactants.Type: GrantFiled: June 8, 2001Date of Patent: July 13, 2004Assignee: Lipocine, Inc.Inventors: Feng-Jing Chen, Mahesh V. Patel, David T. Fikstad
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Patent number: 6753009Abstract: The invention relates to an immediate release tablet capable of being chewed or disintegrated in the oral cavity, which comprises a pharmaceutically active ingredient, and a matrix comprising polyethylene oxide having a weight average molecular weight of from about 500,000 to about 10,000,000. The tablet possesses exceptionally good mouthfeel and stability.Type: GrantFiled: March 13, 2002Date of Patent: June 22, 2004Assignee: McNeil-PPC, Inc.Inventors: Joseph Luber, Frank J. Bunick
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Patent number: 6749882Abstract: The present invention relates, in part, to a nicotine-containing composition that can be readily dissolved in a beverage such as coffee. The composition includes nicotine as an active ingredient, a water-soluble filler, and in some instances, a binder. The composition can be provided as a tablet or a powder and is capable of dissolving in the beverage within a very short period of time. The present invention also relates, in part, to a method for preparing a beverage comprising nicotine. The present invention also encompasses compositions including coffee and nicotine including nicotine-coated coffee beans, or a packet containing compositions including desired amounts of coffee and nicotine.Type: GrantFiled: May 17, 2001Date of Patent: June 15, 2004Inventor: Stephen Fortune, Jr.
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Patent number: 6746692Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.Type: GrantFiled: April 4, 2002Date of Patent: June 8, 2004Assignee: Beecham Pharmaceuticals (Pte) LimitedInventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
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Patent number: 6743443Abstract: The present invention provides an intraoral quickly disintegrating tablet containing a phosphodiesterase inhibitor having an effect of improving the erectile dysfunction and a method for manufacturing the tablet. The present invention also provides an intraoral quickly disintegrating tablet containing a slightly soluble pharmaceutical agent having an improved solubility and a method for manufacturing the tablet. That is, it is an intraoral quickly disintegrating tablet containing a cyclic GMP phosphodiesterase inhibitor and a saccharide, and a method for manufacturing the tablet.Type: GrantFiled: April 5, 2001Date of Patent: June 1, 2004Assignee: Eisai Co., Ltd.Inventors: Hisao Furitsu, Akira Kato, Takayuki Ohwaki, Masanobu Yasui
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Patent number: 6740339Abstract: Quickly disintegrating solid preparations which contain: a) an active ingredient; b) D-mannitol having an average particle size of 30 &mgr;m to 300 &mgr;m; c) a disintegrating agent; and d) celluloses.Type: GrantFiled: December 17, 2001Date of Patent: May 25, 2004Assignee: Takeda Chemical Industries, Ltd.Inventors: Kazuhiro Ohkouchi, Hiroyoshi Koyama
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Patent number: 6733749Abstract: A lozenge for the treatment of Hemophilus influenzae infections of the mouth throat and nasal passage is disclosed which comprises a lytic enzyme composition specific for Hemophilus influenzae, and a lozenge carrier for delivering said lytic enzyme.Type: GrantFiled: February 27, 2002Date of Patent: May 11, 2004Assignees: New Horizons Diagnostics Corporation, Rockefeller UniversityInventors: Vincent Fischetti, Lawrence Loomis
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Patent number: 6719996Abstract: A pharmaceutical composition for oral administration of an active compound having a bioavailability of 20% or less. The composition comprises, based on its total weight, from 0.01% to about 15% (w/w) of said active compound molecularly dissolved in the composition, from 30 to 80% (w/w) of an edible lipid matrix and from 1 to 20% (w/w) of an edible emulsifier, the ratio between the dose weight of the active compound and its solubility in the composition being equal to or greater than 0.6 ml. The high percentage of fat (30-80%) enables a considerable increase the amount of the drug that is molecularly dispersed in the dosage form, thus allowing a significant reduction in the number of unit doses that must be taken daily-by patients.Type: GrantFiled: December 10, 2001Date of Patent: April 13, 2004Assignee: Hoffmann-La Roche Inc.Inventors: Martin Kuentz, Dieter Roethlisberger
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Patent number: 6716453Abstract: A process for increasing the percentage of active ingredient relative to non-active excipient in a compressible formulation, and also for reducing tablet size, by excluding an amount of the excipient and including in its place a reduced amount of a polysaccharide material.Type: GrantFiled: May 22, 2000Date of Patent: April 6, 2004Assignee: Verion, Inc.Inventors: Jerome W. Harden, Duane Glover, Bruce K. Redding, Jr.
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Patent number: 6709670Abstract: Preparations to be applied to the oral or nasal cavity which contain aminoethanesulfonic acid and a mucosal stimulant. When these preparations are applied to the oral or nasal cavity, aminoethanesulfonic acid can be quickly and efficiently absorbed via the activated oral or nasal mucosa. The administration of these preparations quickens recovery from fatigue.Type: GrantFiled: January 2, 2002Date of Patent: March 23, 2004Assignee: Nippon Chemical Works Co., Ltd.Inventors: Toshiki Tanaka, Yasushi Furuta
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Patent number: 6699496Abstract: An enzyme in a dosage form for oral use in mammals is provided, wherein the enzyme has an activity of converting fat in a food material into 1,3-diglyceride and/or 1-monoglyceride. The enzyme has never been used conventionally for oral dosing to mammals. The enzyme in an oral dosage form can effectively decrease the body fat and/or internal fat in mammals in the course of general dietary life.Type: GrantFiled: December 3, 1999Date of Patent: March 2, 2004Assignee: Amano Enzyme Inc.Inventors: Yuzo Kojima, Hiroyasu Andoh
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Patent number: 6680071Abstract: This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (&mgr;receptor) agonist, such as fentanyl, or a salt thereof, characterized in that the composition is in the form of a fast-dispersing dosage form designed to release the active ingredient rapidly in the oral cavity. A process for preparing such a composition and the use of such a composition as an analgesic, for the treatment of chronic pain and/or breakthrough pain, as an anesthetic premedication, for the induction of anesthesia, as a sedative and/or for the treatment of anxiety are also provided.Type: GrantFiled: January 14, 2002Date of Patent: January 20, 2004Assignee: R. P. Scherer Technologies, Inc.Inventors: Edward Stewart Johnson, Jon Lacy
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Patent number: 6669952Abstract: A composition is provided comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which the plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. Also provided is a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.Type: GrantFiled: March 30, 2001Date of Patent: December 30, 2003Assignee: Solae, LLCInventors: Doyle H. Waggle, Susan M. Potter, E. C. Henley
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Patent number: 6667050Abstract: The present invention relates to a chewable, palatable oral contraceptive tablet, comprising an oral contraceptive agent, a chewable carrier suitable for human consumption, and not comprising a ferrocene compound, as well as use of these tablets in a method of human female oral contraception, and in a method of enhancing compliance with a human female oral contraceptive regimen.Type: GrantFiled: June 12, 2001Date of Patent: December 23, 2003Assignee: Galen (Chemicals) LimitedInventors: Roger M. Boissonneault, Tina M. deVries
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Patent number: 6663849Abstract: A method of making antacid coated chewing gum products comprises the steps of providing chewing gum cores; providing a coating syrup comprising a bulk sweetener, calcium carbonate and a binding agent; and applying the coating syrup to the cores and drying the syrup to produce a sugarless coating on the cores. The coating on the cores produces a high viscosity in saliva when the gum is chewed, in that 4.5 grams of said coating dispersed in 30 ml of water has a Brookfield viscosity at 23° C. of at least 1.6 centipoise.Type: GrantFiled: September 1, 2000Date of Patent: December 16, 2003Assignee: Wm. Wrigley Jr. CompanyInventors: Daniel J. Zyck, Michael J. Greenberg, David G. Barkalow, Scott W. Marske, Philip W. Urnezis, Philip Mazzone
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Patent number: 6660299Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin. Preferably, the dosage is provided by a bilayer tablet.Type: GrantFiled: July 24, 2001Date of Patent: December 9, 2003Assignee: Beecham Pharmaceuticals LimitedInventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
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Patent number: 6656493Abstract: Improved edible films for mucoadhesion are provided. The films include at least three types film forming agents other than pullulan, such as maltodextrins, hydrocolloids and fillers. Medicaments and other additive agents can also be incorporated into the edible films. In this regard, the edible films can be utilized to deliver or release the medicaments into an oral cavity, thereby providing effective oral treatment with respect to, for example, oral cleansing and breath freshening.Type: GrantFiled: July 30, 2001Date of Patent: December 2, 2003Assignee: Wm. Wrigley Jr. CompanyInventors: Michael R. Dzija, David G. Barkalow, Albert H. Chapdelaine, Daniel J. Zyck
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Patent number: 6646006Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes.Type: GrantFiled: February 1, 2002Date of Patent: November 11, 2003Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: John P. Cooke, Victor J. Dzau, Gary H. Gibbons
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Patent number: 6641836Abstract: A composition and method for enhancing immune response and improving the overall health of canines is provided which includes feeding the canines a dietary composition containing an effective amount of garlic in an amount of from about 1 to 10 g/kg diet. The dietary composition, when fed to canines, provides antioxidant, anticancer, and immunomodulatory benefits. The canines are fed the composition containing an effective amount of garlic in a quantity and frequency appropriate for their nutritional needs resulting in an enhanced immune response by increased lymphocyte blastogenesis and improves the overall health of the animal.Type: GrantFiled: April 30, 2001Date of Patent: November 4, 2003Assignee: The Procter & Gamble CompanyInventors: Michael G. Hayek, Stefan Patrick Massimino, Katherine P. Boebel
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Patent number: 6627214Abstract: Fumaric acid is added in amounts sufficient to reduce the burn sensation commonly associated with propionic acid derivatives.Type: GrantFiled: May 4, 1999Date of Patent: September 30, 2003Assignee: McNeil-PPC, Inc.Inventors: Frank J. Bunick, Feng Lin
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Patent number: 6627221Abstract: The invention relates to a solid pharmaceutical form of administration containing a diphosphonic acid or a physiologically compatible salt thereof as the active substance, wherein the active substance is present in granulate form, optionally together with pharmaceutical adjuvants in the inner phase, and the outer phase contains a lubricant in the form of less than 5% by weight of stearic acid relative to the total weight of the form of administration.Type: GrantFiled: July 20, 2001Date of Patent: September 30, 2003Assignee: Hoffmann-La Roche Inc.Inventors: Rolf-Dieter Gabel, Walter Preis, Heinrich Woog
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Patent number: 6620791Abstract: The invention provides edible compositions such as solid particulate sweeteners, boiled sweets, chocolate and chewing gum, wherein the compositions comprise at least 10% on a dry weight basis of one or more substances having an endothermic heat of solution of at least −30 kJ/kg and at least 10% on a dry weight basis of a substantially amorphous solid trehalose. The one or more substances having an endothermic heat of solution may comprise dextrose monohydrate or a crystalline sugar alcohol. The invention also provides processes suitable for the production of such edible compositions, wherein the processes comprise the step of dry mixing amorphous trehalose particles in an amount of at least 10% based on the dry weight of the composition with one or more other edible ingredients to form a dry mixture.Type: GrantFiled: April 16, 2002Date of Patent: September 16, 2003Assignee: British Sugar PLCInventors: Julian Michael Cooper, Wei Tian
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Patent number: 6613346Abstract: Products and methods of delivering medicaments are provided. The product includes a chewing gum center including a compressible powder that is compressed around the center. The powder includes a medicament that may or may not be encapsulated.Type: GrantFiled: June 28, 2001Date of Patent: September 2, 2003Assignee: Wm. Wrigley, Jr. CompanyInventors: Donald Seielstad, Henry Tyrpin, Kevin Broderick, James Maxwell, David Record
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Patent number: 6610325Abstract: This pharmaceutical medicine comprises an iron salt, not less than two polyols, a binding agent, a lubricating agent, and a flavoring agent. The dose of elemental iron is not less than 5 mg, and preferably 10 mg to 15 mg per tablet. The proportion of one of the polyols on its own is not less than 10%, and preferably not less than 20% of the total mass of the tablet, the overall proportion of the polyols being not less than 50% and preferably not less than 75%. One of the two polyols is xylitol, comprising not less than 10%, and preferably not less than 20%. The other polyol is sorbitol and/or mannitol.Type: GrantFiled: October 23, 2000Date of Patent: August 26, 2003Assignee: Laboratoire InnotheraInventors: Catherine Meignant, Stephanie Verdier
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Patent number: 6605296Abstract: A food supplement with advantageous physiological effects containing the following essential constituents in a support material (e.g. dairy products, margarine, fruit juice, plant juice, yeast, pectin or olive oil): lecithin, red wine extract and D-alpha-tocopherolacetate in amount ranging from 0.05 to 10.0 parts by weight.Type: GrantFiled: June 14, 2000Date of Patent: August 12, 2003Assignee: Numico Research B.V.Inventor: Franz Stuckler
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Patent number: 6602518Abstract: Products and methods of delivering medicaments are provided. The product includes a consumable center and a compressible powder that is compressed around the center. The powder includes a medicament that may or may not be encapsulated.Type: GrantFiled: January 15, 2002Date of Patent: August 5, 2003Assignee: Wm. Wrigley Jr. CompanyInventors: Donald Seielstad, Henry Tyrpin, Kevin Broderick, James Maxwell, David Record
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Patent number: 6596298Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, methyl salicylate, eucalyptol and menthol. The edible films are effective at killing the plaque-producing germs that cause dental plaque, gingivitis and bad breath. The film can also contain pharmaceutically active agents. Methods for producing the films are also disclosed.Type: GrantFiled: September 14, 1999Date of Patent: July 22, 2003Assignee: Warner-Lambert CompanyInventors: Sau-Hung Spence Leung, Robert S. Leone, Lori D. Kumar
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Patent number: 6592896Abstract: A novel composition for treating symptoms such as symptoms of a common cold, a sore throat, congestion, laryngitis, mucous membrane inflammation and sialorrhea is disclosed. The composition includes ingredients to obtainable from turmeric extract, ginger root powder, and horseradish root powder. This composition can be orally administered a patient. The composition may further include ingredients obtainable from slippery elm bark powder and green tea. This composition may further include a pharmaceutically acceptable carrier for oral administration. A method of administering this composition orally to a patient to treat symptoms of a common cold, a sore throat, congestion, laryngitis, mucositis, sialorrhea and mucous membrane inflammation is also disclosed. To treat these symptoms, the composition is administered to a patient suffering one to fifteen times daily, as needed. To achieve the best effect, the composition should be held in the mouth of a patient for 5 to 60 minutes.Type: GrantFiled: August 6, 2001Date of Patent: July 15, 2003Assignee: The Quigley CorporationInventor: Richard Allen Rosenbloom
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Patent number: 6582738Abstract: A process for preparing a chewing gum tablet includes cooling a chewing gum composition to a temperature at which the gum composition is brittle, and grinding the cooled, brittle gum composition to form a chewing gum powder. The gum composition can be cooled by mixing it with a coolant, such as solid carbon dioxide, prior to grinding. The chewing gum powder is mixed with an active composition comprising a nutritional supplement, such as one or more vitamins, minerals, or herbs, to form a nutritional supplement-containing powder. The mixture of gum powder and the nutritional supplement, along with other optional additives, is then granulated to form nutritional supplement-containing granules. These granules are then compressed to form chewing gum tablets.Type: GrantFiled: November 27, 2001Date of Patent: June 24, 2003Assignee: Deseret Laboratories, Inc.Inventor: Scott A. Gubler
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Patent number: 6582753Abstract: A process and product is taught for producing vitreous molten mass from sweeteners by means of an extruder, in particular a double screw extruder. The sweetener is introduced into an inlet zone of the extruder, is extruded in a melting zone at an increased temperature, in a vacuum zone at a reduced pressure and increased temperature, and finally in a cooling zone at a reduced temperature, forming a vitreous molten mass.Type: GrantFiled: January 19, 2001Date of Patent: June 24, 2003Assignee: SĂ¼dzucker AGInventors: Ingrid Willibald-Ettle, Ondrej Mikla
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Patent number: 6582720Abstract: The present invention provides a gastric and/or duodenal adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach and/or duodenum and one or more of ingredients selected from water insoluble polymers, polyglycerin fatty acid esters, lipids and waxes, with a polymer having adhesive capacity onto the surface of the mucosa of a digestive tract under acid conditions and separates from the mucosa of the digestive tract in neutral or alkaline conditions. This composition adheres only to the mucosa of the stomach and/or duodenum and releases the medicament over long hours so that sufficient effects are available by a small amount of the medicament.Type: GrantFiled: September 7, 2000Date of Patent: June 24, 2003Assignee: Kowa Co., Ltd.Inventors: Toshio Inagi, Hiroyuki Shirai, Norikazu Yamaguchi, Takeshi Nishino
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Patent number: 6579535Abstract: Chewable tablets and particulate food and pharmaceutical products are disclosed which are made from agglomerates comprising an alcohol sugar such as mannitol and a high intensity sweetener such as Aspartame from which agglomerate tablets may be directly compressed, and processes for making the agglomerates and tablets. The tablets or particulate product containing the agglomerate may contain active ingredients blended with the agglomerate or as part of the agglomerate structure. Tablets and particulate products according to the invention can contain active ingredients such as pharmaceuticals (e.g., antacids, analgesics, cough medicine, drugs, etc.) breath sweeteners, vitamins and dietary supplements, to name a few. The high intensity sweetener containing agglomerates can also be used to make solid food mix type products such as sugar free ice tea mixes.Type: GrantFiled: March 19, 2001Date of Patent: June 17, 2003Assignee: Advanced Technology Pharmaceuticals CorporationInventors: William Valentine, William K. Valentine
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Patent number: 6579534Abstract: A composition is provided comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which the plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. Also provided is a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.Type: GrantFiled: April 4, 2001Date of Patent: June 17, 2003Assignee: Solae, LLCInventors: Doyle H. Waggle, Susan M. Potter, Edna C. Henley
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Patent number: 6576677Abstract: The present invention provides a composition alleviated in a bitter taste or the like of a medicament. The present invention relates to a composition comprising a basic medicament having an unpleasant taste and polyvinylpyrrolidone and/or copolyvidone; or a method for alleviating an unpleasant taste of a basic medicament having the unpleasant taste by adding polyvinylpyrrolidone and/or copolyvidone. The present invention further provides a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (3) propylene glycol and/or D-sorbitol; a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (4) an antioxidant; and a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (5) a colorant or flavor containing a sulfuric acid or sulfurous acid group.Type: GrantFiled: April 28, 2000Date of Patent: June 10, 2003Assignee: Eisai Co., Ltd.Inventors: Koji Ukai, Tsutomu Harada
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Patent number: 6576253Abstract: The present invention provides food bars for consumption by pregnant women, lactating women or women of childbearing potential that are attempting to become pregnant containing one or more vitamins and/or minerals, DHA, one or more DHA taste-masking agents and, optionally, one or more anti-constipation and regularity-maintaining agents, methods for preparing these food bars, and methods for supplementing the dietary requirements of pregnant women, lactating women or women of childbearing potential that are attempting to become pregnant.Type: GrantFiled: February 19, 2002Date of Patent: June 10, 2003Assignee: PBM Pharmaceuticals, Inc.Inventors: Paul B. Manning, Jack H. Schramm, James W. McGrath, Jr.
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Patent number: 6572886Abstract: The invention relates to lozenges comprising a sweetening component and a binder, wherein more than 50% of the sweetening component consists of dextrose, this percentage being expressed by weight, based on the total weight of the sweetening component. The invention further relates to a process for the preparation of such lozenges.Type: GrantFiled: January 16, 2001Date of Patent: June 3, 2003Assignee: Roquette FreresInventors: Guillaume Ribadeau-Dumas, VĂ©ronique Beaudier
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Patent number: 6572876Abstract: A composition is provided comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which the plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. Also provided is a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.Type: GrantFiled: March 22, 2001Date of Patent: June 3, 2003Assignee: Solae, LLCInventors: Doyle H. Waggle, Susan M. Potter, E. C. Henley
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Patent number: 6569463Abstract: The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutrionals, cosmeceuticals and diagnostic agents.Type: GrantFiled: March 6, 2001Date of Patent: May 27, 2003Assignee: Lipocine, Inc.Inventors: Mahesh V. Patel, Feng-Jing Chen
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Patent number: 6565873Abstract: The present invention relates to a controlled release system useful for site specific delivery of biologically active ingredients or sensory markers, over an extended period of time, targeting biological surfaces comprising the oral cavity and mucous membranes of various tissues, as well as the controlled release of the biological active ingredients or sensory markers. The controlled release system of the present invention is a nano-particle, having an average particle diameter of from about 0.01 microns to about 10 microns, which comprises a biodegradable solid hydrophobic core and a bioadhesive/mucoadhesive positively charged surface. The invention also relates to the use of the nano-particles of the present invention in consumer oral hygiene products, such as toothpaste or mouthwash, for treatment and prevention of periodontal disease. The nano-particles of the present invention are particularly effective for targeted controlled delivery of biological active ingredients into the periodontal pocket.Type: GrantFiled: October 25, 2000Date of Patent: May 20, 2003Assignee: Salvona LLCInventors: Adi Shefer, Shmuel David Shefer
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Patent number: 6565876Abstract: A composition is disclosed suitable for the prevention and/or treatment of cardiovascular and neurocerebral disorders, tissue anoxic forms, muscular energy deficits, inflammatory-type abnormalities, alterations of blood coagulation such as thrombosis, and tissue proliferation forms, that may take the form of a dietary supplement, dietetic support or of an actual medicine, which comprises as characterizing active ingredients: (a) propionyl L-carnitine or a pharmacologically acceptable salt thereof; and (b) an inositol phosphate, particularly the inositol hexaphosphate (IP6).Type: GrantFiled: December 21, 2000Date of Patent: May 20, 2003Assignee: Sigma-Tau HealthScience S.p.A.Inventor: Claudio Cavazza
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Patent number: 6565877Abstract: A taste masked composition which comprises a bitter tasting drug, a combination of two enteric polymers comprising, a methacrylic acid copolymer and a phthalate polymer is described. The composition of the present invention is prepared by dissolving the active ingredient, the methacrylic acid copolymer and the phthalate polymer in a solvent and recovering the composition from the solution thereof.Type: GrantFiled: June 5, 2000Date of Patent: May 20, 2003Assignee: Ranbaxy Laboratories LimitedInventors: Gour Mukherji, Sandhya Goel, Vinod Kumar Arora
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Patent number: 6562372Abstract: A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a suspension and then the formed suspension is spray-dried. The powder containing tocotrienol, which has excellent storage stability and free flowability, can be used in preparing a tablet which comprises the powder compressed into a tablet form.Type: GrantFiled: April 5, 2000Date of Patent: May 13, 2003Assignee: Fuji Chemical Industry Co., Ltd.Inventors: Shinichiro Yokoi, Nobukazu Tanaka, Yoshiharu Horita, Terumasa Hosokawa, Takeshi Shishido, Heiji Ikushima
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Patent number: 6558692Abstract: Methods and products for delivering a medicament or agent to an individual are provided. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.Type: GrantFiled: January 11, 2001Date of Patent: May 6, 2003Assignee: Wm. Wrigley Jr. CompanyInventors: Ronald L. Ream, Michael J. Greenberg, William J. Wokas, Christine L. Corriveau
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Patent number: 6555093Abstract: The composition comprises a mixture of olive oil (Olea europea L.) and parsley oil (Petroselinum sativum Hoffm., Petroselinum crispum Mill., Carum petroselinum Benth & Hooker), in a ratio of olive oil: parsley oil, by weight, comprised between 1 and 7. Additionally the composition may contain other vegetable oils, mint oil, menthol and chlorophyll. These compositions may be presented in several forms including sweets, chewing-gum, dentifrice paste, mouthwashes and pharmaceutical compositions, especially as soft gelatine capsules, for which purpose they incorporate the suitable additives, vehicles and excipients for its processing in the desired form of presentation. The composition is suitable for the treatment of halitosis.Type: GrantFiled: November 28, 2001Date of Patent: April 29, 2003Assignee: Biocosmetics, S.L.Inventor: Maria Alvarez Hernandez
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Patent number: 6555127Abstract: Methylphenidate or other drugs are provided in a formulation for oral administration that releases the drug in two or more pharmacokinetic spikes, by combining different release forms in a single formulation. In a preferred embodiment for methylphenidate, the first pharmacokinetic spike is achieved by the release of taste-masked methylphenidate which is not enterically coated, while a second pharmacokinetic spike is achieved by the release of methylphenidate in a finely divided form from enterically coated pellets or microparticles formulated for rapid release following dissolution of the enteric coating. A critical aspect of the formulation is the inclusion of excipients that create a burst release following the initial rapid release and uptake. The formulation can be administered as a paste, jelly, suspension, or fast dissolving wafer. To manipulate the dose, the formulation can be provided, for example, as a paste packaged in a tube similar to those used to dispense toothpaste.Type: GrantFiled: January 19, 2001Date of Patent: April 29, 2003Assignee: Pharmaceutical Discovery CorporationInventor: Solomon S. Steiner