Potassium Chloride Patents (Class 424/679)
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Patent number: 5962032Abstract: Pharmaceutical compositions for regulating unitary smooth muscle polarization containing aqueous solutions based on magnesium, potassium, sodium and optionally calcium salts, at least one sugar and at least one amino acid, combined with a copper salt or a zinc salt. The invention further relates to a kit containing at least two of these pharmaceutical compositions.Type: GrantFiled: September 12, 1997Date of Patent: October 5, 1999Inventor: Guy Drouault
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Patent number: 5958464Abstract: A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content is lower than conventional calcium treatments used for this purpose. The propylene glycol gives the cow an energy boost and sweetens the taste so the cow does not object to it as it does to conventional gels and liquids. The B vitamins stimulate the cow's appetite. The minerals replace minerals lost in the milk and also help the cow absorb calcium. The composition of the present invention is in a liquid form and is preferably administered using a 200-300 cc drench gun. The end of the dispensing tube of the drench gun is placed between the teeth and cheek of the cow near the receptors that stimulate the esophageal groove reflex.Type: GrantFiled: November 12, 1997Date of Patent: September 28, 1999Inventor: Jack W. Register
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Patent number: 5955067Abstract: A composition is disclosed which is useful in alleviating, at least in part, symptoms of acne vulgaris, psoriasis or seborrhea, which includes a potassium-based compound a dermatologically acceptable base for the potassium-based compound, which is preferably a potassium salt, and which include potassium acetate, potassium aluminate, potassium arsenite solution, potassium bicarbonate, potassium bisulfate potassium bitartararte, potassium bromide, potassium carbonate, potassium chloride, potassium citrate, potassium gluconate, potassium glycerophosphate, potasium iodate, potassium iodide, potassium manganate, potassium permanganate, potassium phosphate monobasic potassium phosphate dibasic, potassium phosphate tribasic, potassium phosphite or a combination thereof. The composition is topically applied to the areas of a patient's skin which are afflicted with any of acne vulgaris, psoriasis or seborrhea.Type: GrantFiled: July 23, 1996Date of Patent: September 21, 1999Inventors: Eray Oge, Gary Goodwin
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Patent number: 5945449Abstract: A sterile bicarbonate concentrate for use in the present invention relates to a sterile calcium-free bicarbonate concentrate for use in peritoneal dialysis, hemofiltration, cardiac bypass surgery and in electrolyte replacement therapy.Type: GrantFiled: October 31, 1997Date of Patent: August 31, 1999Assignee: Dialysis Solutions Inc.Inventors: Larry Joseph Purcell, Sheldon William Tobe
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Patent number: 5849266Abstract: The invention relates to an oral composition for the treatment and prevention of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.Type: GrantFiled: April 4, 1995Date of Patent: December 15, 1998Assignee: Perio Products Ltd.Inventor: Michael Friedman
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Patent number: 5846572Abstract: A sterile, pyrogen-free fluid replacement solution for intravenous infusion is disclosed that consists essentially of a physiologically acceptable sodium salt, a physiologically acceptable potassium salt, an osmolality control agent, and, optionally, a component selected from the group consisting of a physiologically acceptable calcium salt and a physiologically acceptable magnesium salt.Type: GrantFiled: June 26, 1997Date of Patent: December 8, 1998Assignee: East & Midlothian NHS TrustInventor: Francis George Richard Prior
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Patent number: 5827545Abstract: A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content of 25 grams per dose is lower than conventional calcium treatments used for this purpose. The propylene glycol gives the cow an energy boost and sweetens the taste so the cow does not object to it as it does to conventional gels and liquids. The B vitamins stimulate the cow's appetite. The minerals replace minerals lost in the milk and also help calcium absorption. The composition of the present invention is in a liquid form and is preferably administered using a 200 cc drench gun. The end of the dispensing tube of the drench gun is placed between the teeth and cheek of the cow and inserted all the way to the back of the cheek.Type: GrantFiled: February 8, 1996Date of Patent: October 27, 1998Inventor: Jack W. Register
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Patent number: 5776503Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: July 24, 1997Date of Patent: July 7, 1998Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5747071Abstract: An artificial plasma-like substance having at least one water soluble polysaccharide oncotic agent selected from the group consisting of high molecular weight hydroxyethyl starch, low molecular weight hydroxyethyl starch, dextran 40 and dextran 70, and albumin which is buffered by lactate and has a pre-administration pH of between 5 and 6.5 is disclosed. Also disclosed is an artificial plasma-like solution having at least two water soluble polysaccharide oncotic agents one of which is eliminated from the circulation slowly and the other of which is eliminated from the circulation quickly. Supplimentation of the plasma-like solution with certain ions is described. A system for administration of the plasma-like solution to a subject wherein the system comprises a first and second solution each having particular buffers is described. The plasma-like solution including cryoprotective adducts is also disclosed.Type: GrantFiled: June 5, 1995Date of Patent: May 5, 1998Assignee: BioTime, Inc.Inventors: Paul E. Segall, Harold D. Waitz, Hal Sternberg, Judith M. Segall
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Patent number: 5719119Abstract: Parenteral nutrition aqueous solutions are provided which preferably contain glutamine together with other organic nitrogen containing compounds. The respective concentrations of the compounds present in any given such solution are typically approximately multiples of the concentration of the same compounds as found in normal human plasma, and the respective mole ratios of various such compounds in any given such solution relative to one another are approximately the same mole ratio associated with the same compounds as found in normal human plasma. Processes for using such solutions are provided.Type: GrantFiled: April 26, 1993Date of Patent: February 17, 1998Assignee: British Technology Group, Ltd.Inventor: Richard L. Veech
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Patent number: 5698230Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: March 24, 1997Date of Patent: December 16, 1997Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5681569Abstract: This invention relates to a composition, preferably in the form of a beverage, whereby cellular hydration and drinkability are enhanced by the combination of green tea solids with selected levels and types of electrolytes and carbohydrates. The compositions comprise (a) from about 0.01% to about 0.35% flavanols; (b) from about 0.01% to about 0.3% sodium ions; (c) from about 0.005% to about 0.08% potassium ions; (d) from about 0.1% to about 20% of a carbohydrate which provides; (i) from about 0.05% to about 10.0% fructose; (ii) from about 0.05% to about 10.0% glucose; and (e) water.Type: GrantFiled: November 6, 1995Date of Patent: October 28, 1997Assignee: The Procter & Gamble CompanyInventors: James Thaddeus Kuznicki, Lana Sandman Turner
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Patent number: 5670176Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: April 4, 1995Date of Patent: September 23, 1997Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5631025Abstract: An improved peritoneal dialysis solution and methods of administering same to a patient are provided. Pursuant to the present invention, the sodium concentration in the solution is decreased thus causing sodium to be transported from the circulation to the peritoneal cavity. This provides for an improved ultrafiltration profile for the same initial osmolality when compared to standard solutions. Also, the same ultrafiltration profile as standard solutions can be achieved with lower initial osmolalities.Type: GrantFiled: April 18, 1995Date of Patent: May 20, 1997Assignee: Baxter International Inc.Inventors: Ty R. Shockley, Leo Martis, Lee W. Henderson, John Moran, Masaaki Nakayama
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Patent number: 5616324Abstract: A synergistic mixture particularly suitable for the treatment of animals whic consists of at least two of the group consisting of DL.Phenylalanine, Ruta Graveolans and Corydali Bulbosa together with a carrier to make up a required volume, the mixture having a pro-inflammatory effect which accelerates the healing process of inflammation. It is preferred that there is provided mixture of DL.Phenylalanine with one product selected from the group of Ruta Graveolans and Corydalis Bulbosa. In a specific form, the mixture also includes Nicotinic Acid.Type: GrantFiled: May 31, 1995Date of Patent: April 1, 1997Inventors: Antoinette Foster, Don Foster
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Patent number: 5540842Abstract: A granular to fine-granular dry mix powder (an artificial kidney perfusion component A of uniform composition) for use in the preparation of an artificial kidney perfusion fluid for bicarbonate dialysis and a method of producing the same.A granular to fine-granular Composition A comprising granules each comprised of a plurality of NaCl grains carrying KCl, CaCl.sub.2, MgCl.sub.2 and sodium acetate adhered to the surface of each grain.NaCl, KCl CaCl.sub.2, MgCl.sub.2 and sodium acetate are mixed in the presence of not less than 10 weight parts of water based on 100 weight parts of sodium acetate and the resultant mixture is heated at not less than 50.degree. C. to bring the sodium acetate into a transiently molten state and mixing acetic acid with the same mixture.Type: GrantFiled: December 13, 1993Date of Patent: July 30, 1996Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Hideyuki Aoyama, Hisao Mukai, Kazuya Murakami
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Patent number: 5536155Abstract: Preservatives for cut flowers which include an extract from eucalyptus leaves as a bactericidal agent. The preservative further includes at least one additive selected from naturally occurring bactericidal substances not found in the extract from eucalyptus leaves, saccharides, disinfectants, water-soluble mineral substances, calcium phosphate compounds, surface active substances and plant hormones. The preservative is effective to keep cut flowers fresh for an extended period of time, does not harmfully effect the flowers, and is safe and has no toxic effect to young children, when it is drunk by mistake.Type: GrantFiled: July 27, 1994Date of Patent: July 16, 1996Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Kouji Futaki, Keiko Shigeno, Keiko Hoshi
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Patent number: 5522726Abstract: The present invention is directed to a method for anesthetizing teeth which does not require an injection into the gum in order to anesthetize a tooth (or teeth) which requires attention. The method comprises the step of applying a composition having a high concentration of potassium to a tooth requiring caries removal or manual manipulation thereof. The composition is adapted to anesthetize the tooth so that the tooth may be drilled or manually manipulated. It has been discovered that the potassium enters the dentinal tubules and odontoblastic fibrils and penetrates the pulpal tissues of the tooth for anesthetizing the tooth without having to inject anesthetics into the gum surrounding the tooth.Type: GrantFiled: October 27, 1994Date of Patent: June 4, 1996Inventor: Milton Hodosh
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Patent number: 5505962Abstract: An improved controlled release tablet formulation for the release of potassium chloride through a differentially permeable membrane from which the release of potassium chloride can be accurately controlled to minimize the likelihood of producing high localized concentrations of potassium within the gastrointestinal tract.Type: GrantFiled: September 16, 1994Date of Patent: April 9, 1996Assignee: Elan Corporation, plcInventor: Randall T. Sparks
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Patent number: 5504072Abstract: Enteral nutritional composition comprising 4-30% lipid component, 65-80% carbohydrate component and 16-25% protein component, based on total caloric content, wherein said protein comprises by weight 14-30% glutamine and 5-33% arginine and said composition has a nonprotein calorie to grams of nitrogen ratio of 150:1 to 80:1.Type: GrantFiled: February 10, 1995Date of Patent: April 2, 1996Assignee: Sandoz Nutrition Ltd.Inventors: Mary K. Schmidl, Candis Kvamme
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Patent number: 5498427Abstract: Perfusion and preservation and/or reperfusion solutions for surgery and organ transplantation, including that of the heart, a feature of which solutions is the inclusion of at least one antioxidant compound, such as a trapping agent for free oxygen radicals, in particular glutathione in the reduced state or N-acetylcysteine, said solutions possessing a zero or greatly reduced partial pressure of oxygen which is maintained substantially at this value up to the time of use. The solution is preferably presented in flexible bags impermeable to oxygen.Type: GrantFiled: August 18, 1994Date of Patent: March 12, 1996Assignee: Pasteur Merieux Serums et VaccinesInventor: Philippe Menasche
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Patent number: 5464619Abstract: This invention relates to a composition, preferably in the form of a beverage, whereby cellular hydration and drinkability are enhanced by the combination of green tea solids with selected levels and types of electrolytes and carbohydrates. The compositions comprise (a) from about 0.01% to about 0.35% flavanols; (b) from about 0.01% to about 0.3% sodium ions; (c) from about 0.005% to about 0.08% potassium ions; (d) from about 0.1% to about 20% of a carbohydrate which provides; (i) from about 0.05% to about 10.0% fructose; (ii) from about 0.05% to about 10.0% glucose; and (e) water.Type: GrantFiled: June 3, 1994Date of Patent: November 7, 1995Assignee: The Procter & Gamble CompanyInventors: James T. Kuznicki, Lana S. Turner
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Patent number: 5459030Abstract: Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the photodecontamination of platelets using 8-methoxypsoralen.Type: GrantFiled: June 2, 1993Date of Patent: October 17, 1995Assignee: Steritech, Inc.Inventors: Lily Lin, Laurence Corash
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Patent number: 5449522Abstract: This invention provides an immunoenhancement or immunepotentiation therapy comprising administration of potassium, insulin, glucose and, optionally, thyroid, a cholinergic agent and bicarbonate. Therapeutic compositions comprising the above components in appropriate dosages are also provided.Type: GrantFiled: August 24, 1993Date of Patent: September 12, 1995Inventor: Albert F. Hill
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Patent number: 5438042Abstract: An enteral nutritional composition comprising 4-30% of a lipid component, 65-80% of a carbohydrate component, and 16-25% of a protein component, based on total caloric content is disclosed. This protein component of this composition comprises, by weight, 14-30% glutamine and 5-33% arginine. The non-protein calorie to grams of nitrogen ratio ranges from 150:1 and 80:1.Type: GrantFiled: October 8, 1993Date of Patent: August 1, 1995Assignee: Sandoz Nutrition Ltd.Inventors: Mary K. Schmidl, Candis Kvamme
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Patent number: 5434191Abstract: A blood substitute employs combinations of fluoro or perfluorochemicals capable in the presence of emulsifying agents of forming emulsions stable at room temperature and possessing enhanced oxygen carrying capacity; the invention enables preparation of an improved blood substitute, with improved O.sub.2 carrying capacity and stability, as well as lessened anaphylactoid reaction.Type: GrantFiled: August 23, 1993Date of Patent: July 18, 1995Assignee: International Therapeutics Inc.Inventors: Walter B. Dandliker, W. Keith R. Watson, Thomas C. Drees
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Patent number: 5425945Abstract: Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric acid uniformly dispersed throughout the maltodextrin coating. This agglomerated psyllium husk has improved mixability and dispersibility in liquids.Type: GrantFiled: March 14, 1994Date of Patent: June 20, 1995Assignee: The Procter & Gamble CompanyInventor: Melvin A. Barbera
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Patent number: 5417987Abstract: A method for enhancing the effect of a toxicant such as chlorine or potassium on bivalve molluscs such as zebra mussels. Application of serotonin or a serotonin agonist in low concentrations inhibits the mussels' ability to close their valves to protect themselves from the effect of any toxicants in the water. Thus administering serotonin or a serotonin agonist for a period of time, followed by administering a toxicant, substantially enhances the effect of the toxicant on the zebra mussels. Thus less of the toxicant need be administered to control zebra mussels. The concentration of serotonin needed to enhance toxicant control of exotic zebra mussels has been found to be at or below the threshold of serotonin activity on native bivalves, at least those native to the lower Mississippi River. Furthermore, serotonin is naturally degraded rapidly by aquatic microorganisms.Type: GrantFiled: September 16, 1993Date of Patent: May 23, 1995Assignees: Board of Supervisors of Louisiana State University, Agricultural and Mechanical CollegeInventors: Thomas H. Dietz, John W. Lynn, Harold Silverman
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Patent number: 5403577Abstract: The invention relates to an oral composition for the treatment and prevenn of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.Type: GrantFiled: June 12, 1992Date of Patent: April 4, 1995Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Michael Friedman
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Patent number: 5330746Abstract: The invention relates to an oral composition for plaque prevention or tooth hypersensitivity comprising either an antibacterial agent or a hypersensitivity agent embedded in a sustained release carrier such as an acrylic polymer, and a method for the use of said compositions in preventing dental caries, periodontal disease, and tooth hypersensitivity.Type: GrantFiled: June 21, 1989Date of Patent: July 19, 1994Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Petro Products Ltd.Inventors: Michael M. Friedman, Amnon Sintov
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Patent number: 5304724Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the bicarbonate and glutathione are freeze-dried, packaged and separately stored in lyophilized powder form until just preceding the operation, at which time the lyophilized powder containing the bicarbonate and glutathione is dissolved directly into a conventional I.V. solution.Type: GrantFiled: February 19, 1992Date of Patent: April 19, 1994Assignee: Entravision, Inc.Inventor: Walter A. Newton
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Patent number: 5294606Abstract: This invention relates to an isotonic energy composition including the carbohydrates, fructose and maltodextrin, the electrolytes, zinc, chromium, calcium, potassium, magnesium, sodium, and the nutrients vitamin C, citric acid and beta carotene. The electrolytes zinc and chromium are delivered in the form of an organic complex. The invention also relates to a method to use the composition.Type: GrantFiled: November 24, 1992Date of Patent: March 15, 1994Assignee: Reliv' International Inc.Inventor: Carl Hastings
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Patent number: 5290766Abstract: An aqueous cardioplegic solution providing significantly improved cardiac function after a period of exposure to cardioplegia, contains NaCl in the range of 70-110 mM; KCl in the range of 10-16 mM; CaCl.sub.2 in the range of 0.5-1.0 mM; MgCl.sub.2 in the range of 8-16 mM; NaHCO.sub.3 in the range of 10-20 mM; D-Glucose in the range of 5-15 mM; L-Aspartic acid in the range of 5-20 mM; and Lactobionic acid in the range of 0-15 mM.Type: GrantFiled: February 18, 1992Date of Patent: March 1, 1994Assignee: The National Heart Foundation of New ZealandInventor: Yee S. Choong
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Patent number: 5283068Abstract: A procaine acid addition salt, wherein the acid is attached to the diethylamino nitrogen, is complexed with a biologically active organic acid such as a vitamin acid, essential unsaturated fatty acid, C.sub.4 to C.sub.6 hydroxycarboxylic acid or alpha amino acid in stoichiometric ratios of organic acid to procaine acid addition salt to form a double salt complex wherein the organic acid attaches to the p-amino nitrogen. Such double salt complexes protect the procaine molecule from cholinesterase hydrolysis when orally administered to warm blooded animals allowing the complex to be carried intact to the site of damaged cells and across the cell membrane where the double salt complex is disassociated in the cell releasing the organic acid and procaine for cellular repair and regeneration. Procaine hydrochloride is the preferred procaine salt. Preferred acids are citric and vitamin acids including nicotinic acid, ascorbic acid, biotin and folic acid.Type: GrantFiled: September 25, 1992Date of Patent: February 1, 1994Inventor: Robert Koch
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Patent number: 5271947Abstract: A method for reducing the proliferation of dust mites in substrates inhabited by dust mites is accomplished by contacting the substrates such as bedding materials, rugs and upholstered furniture with a sufficient amount of finely divided salt which functions as an acaricide against dust mites, thereby killing the dust mites.Type: GrantFiled: July 24, 1991Date of Patent: December 21, 1993Inventors: Annette Miller, Jeffrey D. Miller
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Patent number: 5238684Abstract: Disclosed here are novel compositions and methods which can be used as a blood substitute to ameliorate adverse physiological effects of blood loss. The novel compositions comprise fluids containing water, electrolytes, glycerol, and additional energy sources.Type: GrantFiled: October 3, 1991Date of Patent: August 24, 1993Assignee: University of FloridaInventors: Melvin J. Fregly, R. Malcolm Privette, Robert Cade
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Patent number: 5236712Abstract: Disclosed here are novel compositions and methods which can be used to reduce or prevent adverse physiological effects of physical exercise or environmental exposure. The novel compositions comprise fluids containing water, sugar, electrolytes, and a substance which is non-toxic to man or animals, can be rapidly absorbed through the gastrointestinal tract, prevents decreases in blood volume, and acts as an energy source.Type: GrantFiled: October 3, 1991Date of Patent: August 17, 1993Assignee: University of FloridaInventors: Melvin J. Fregly, R. Malcolm Privette, Robert Cade
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Patent number: 5232698Abstract: Psyllium husk-containing drink mix compositions comprising small particle size psyllium husk and edible, water soluble salts. The edible, water soluble salts are present at a level sufficient to reduce the gellation rate of the psyllium husk when dispersed in an aqueous solution.Type: GrantFiled: June 12, 1992Date of Patent: August 3, 1993Assignee: The Proctor & Gamble CompanyInventor: Lee A. Hord
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Patent number: 5221537Abstract: Irrigating solutions with thiol or disulfide containing compounds in physiologically acceptable salt solutions are described. The irrigating solutions are useful during surgery, particularly ophthalmic, neural, cardiovascular or otic surgery, to stabilize the affected tissue. Methods for their preparation and use are described.Type: GrantFiled: July 13, 1992Date of Patent: June 22, 1993Inventors: Gerald Hecht, Michael E. Stern, Romulus K. Brazzell
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Patent number: 5200200Abstract: Methods are provided for preparing just before administration unit doses of therapeutic solutions which contain redox active unstable and/or diffusable metabolites such as a ketoacid, a sulfhydryl-contining amino acid, or carbon dioxide. The method involves preparing and storing an aqueous solution of stable components which may or may not contain carbon dioxide. A dry powder comprised of unstable components is also prepared and stored separately. These separate component compositions are packaged in, for example, individual chambers of a common scaled container which is so constructed as to permit the opening, by externally applied manual means or the like, of a passageway between such chambers at the time when usage is contemplated. Thus, a fresh solution in desired full dosage form is preparable just befor administration. Improved container structures for practice of this method are also provided.Type: GrantFiled: April 16, 1990Date of Patent: April 6, 1993Inventor: Richard L. Veech
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Patent number: 5147650Abstract: Disclosed here are novel compositions and methods which can be used to reduce or prevent adverse physiological effects of physical exercise or environmental exposure. The novel compositions comprise fluids containing water, sugar, electrolytes, and a substance which is non-toxic to man or animals, can be rapidly absorbed through the gastrointestinal tract, prevents decreases in blood volume, and acts as an energy source.Type: GrantFiled: December 31, 1990Date of Patent: September 15, 1992Assignee: University of FloridaInventors: Melvin J. Fregly, R. Malcolm Privette, Robert Cade
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Patent number: 5139789Abstract: Cardioplegia solutions having potassium and chloride ion concentrations selected to give a product approximately equal to the product of the potassium and chloride ion concentrations in blood and blood substitutes have been shown to prevent heart cell swelling during cardioplegia.Type: GrantFiled: October 17, 1990Date of Patent: August 18, 1992Assignees: Virginia Commonwealth University, Center for Innovative TechnologyInventor: Clive M. Baumgarten
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Patent number: 5132118Abstract: A method and composition for the preventive and curative treatment of exercise-induced pulmonary hemorrhage in animals. The method comprises administration to the animal of a mixture of urea, alkaline potassium salts and magnesium salts. The composition comprises a mixture of urea, alkaline potassium salts, and magnesium salts, and if required, a pharmaceutically acceptable carrier.Type: GrantFiled: November 29, 1990Date of Patent: July 21, 1992Inventor: John A. Mills
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Patent number: 5130230Abstract: A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water, electrolytes at physiological concentration, dextran 40 at a concentration sufficient for the blood substitute to achieve a colloidal suspension having a fluid osmotic pressure essentially equivalent to mammalian plasma, HEPES buffer at a physiological pH, dextrose, magnesium ion at a concentration of about 0.01M and potassium ion at a concentration greater than 10 mEq per liter sufficient to prevent or arrest cardiac fibrillation. In one embodiment the blood substitute is a multi-solution system wherein the solutions comprise differing levels of the above-indicated components and are administered sequentially to completely replace a subjects circulating blood.Type: GrantFiled: May 8, 1990Date of Patent: July 14, 1992Assignee: Cryomedical Sciences, Inc.Inventors: Paul E. Segall, Harold Waitz, Hal Sternberg
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Patent number: 5126135Abstract: The present invention relates to a dermatological composition composed for cosmetics or medicines for external application to skin and to oral or nasal mucous-membrane. This composition can be applied in particular in the cosmetic or pharmaceutical field, especially in the dermatological cases to regenerate and to revitalize damaged cells by equilibrating electrochemical ion gradients across cell membrane and also by osmotic pressure on the inner face of the cell membrane. A composition based on a water phase in accordence with present invention comprises dextran, glucose, mutan lentinan, NaCl, KCl, and CaCl.sub.2, which are dissolved in the aqueous phase.Type: GrantFiled: June 18, 1991Date of Patent: June 30, 1992Assignee: Japan Fine Chemical Co., Ltd.Inventors: Hajime Yamada, Akira Yamada
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Patent number: 5124144Abstract: The invention provides an orally administered pharmaceutical composition for use in gastrointestinal washes, particularly for diagnostic use, or as a cathartic laxative, of the type containing polyethyleneglycol, anhydrous sodium sulphate, sodium bicarbonate, sodium chloride and potassium chloride, characterized by also containing the following components: saccharin, acesulfame-K and a flavoring chosen from the following: mandarin, fresh fruit flavoring.Type: GrantFiled: April 11, 1990Date of Patent: June 23, 1992Assignee: Giuliani S.p.A.Inventors: Enzo Giorgetti, Virginio Castagnola, deceased, Giuliano Frigerio
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Patent number: 5112622Abstract: Disclosed is a novel therapy involving infusion of specially adapted electrolyte solution comprising essentially physiological concentrations of sodium and other cations and in general higher than physiological concentrations of bicarbonate. The therapy is related to treatment of altered renal function and prophylactic treatment of a patient to resist onset of altered renal function.Type: GrantFiled: January 19, 1990Date of Patent: May 12, 1992Inventor: Klaus F. Kopp
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Patent number: 5104663Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the chloride salts (Ringer solution) are packaged and stored in solution and the bicarbonate and glutathione are freeze-dried and packaged and separately stored in powder form until immediately preceeding the operation, at which time the bicarbonate and glutathione are dissolved directly into the solution of chloride salts. The resulting solution is mixed within 24 hours of use.Type: GrantFiled: September 4, 1990Date of Patent: April 14, 1992Assignee: Entravision, Inc.Inventors: Walter A. Newton, Douglas V. Carter
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Patent number: 5100677Abstract: Processes and compositions are provided for accomplishing fluid therapy using the anions l-lactate, pyruvate, d-betahydroxybutyrate, acetoacetate, or mixtures of such. The racemic d,l-lactate or acetate anion mixtures heretofore used in fluids are now known not to be desirable because they cause adverse and toxic effects when administered to mammals.Type: GrantFiled: December 17, 1986Date of Patent: March 31, 1992Inventor: Richard L. Veech
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Patent number: RE34077Abstract: A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water, electrolytes at physiological concentration, dextran 40 at a concentration sufficient for the blood substitute to achieve a colloidal suspension having a fluid osmotic pressure essentially equivalent to mammalian plasma, HEPES buffer at a physiological pH, dextrose, magnesium ion at a concentration of about 0.01M and potassium ion at a concentration greater than 10 mEq per liter sufficient to prevent or arrest cardiac fibrillation. In one embodiment the blood substitute is a multi-solution system wherein the solutions comprise differing levels of the above-indicated componants and are administered sequentially to completely replace a subjects circulating blood.Type: GrantFiled: October 23, 1990Date of Patent: September 22, 1992Assignee: Cryomedical Sciences, Inc.Inventors: Paul E. Segall, Harold D. Waitz, Hal Sternberg