Processes Patents (Class 536/124)
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Publication number: 20140128658Abstract: The embodiments herein provide a method of synthesizing a novel enriched 10-boron drug for treatment of cancer by Boron Neutron Capture Therapy (BNCT) method. In BNCT, drug containing enriched 10-Boron has the important role in final treatment efficiency. The composition is Enriched 10-Boron Calcium Fructo Borate (E10BCFB). The Calcium Fructo-Borate is found in some vegetables. E10BCFB is in fact an artificial Calcium Fructo-Borate which is synthesized chemically with enriched 10-Boron. E10BCFB becomes an important competitor drug in the fight against some cancerous cells. The composition is applied orally and parenterally.Type: ApplicationFiled: December 24, 2012Publication date: May 8, 2014Inventors: Hanif Kazerooni, Bahram Nasernejad, Abbas Abdolmalaki, Akbar Zare
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Patent number: 8697862Abstract: Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3?-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction.Type: GrantFiled: May 18, 2009Date of Patent: April 15, 2014Assignee: Galecto Biotech ABInventor: Ulf Nilsson
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Patent number: 8691974Abstract: A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedical implants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the present invention relate to systems and methods for the production and control of 3-D architecture and morphology of nano-cellulose biomaterials produced by bacteria using any biofabrication process, including the novel 3-D Bioprinting processes disclosed. Representative processes according to the invention involve control of the rate of production of biomaterial by bacteria achieved by meticulous control of the addition of fermentation media using a microfluidic system. In exemplary embodiments, the bacteria gradually grew up along the printed alginate structure that had been placed into the culture, incorporating it.Type: GrantFiled: September 28, 2010Date of Patent: April 8, 2014Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Paul Gatenholm, Henrik Backdahl, Theodore Jon Tzavaras, Rafael V. Davalos, Michael B. Sano
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Patent number: 8691957Abstract: The present invention is provides a crosslinked hyaluronan powder excellent in swellability in water and a method for simply producing the same. A method for producing the swellable crosslinked hyaluronan powder is characterized by comprising mixing a crosslinking agent with a hyaluronan powder in a state dispersed in a liquid medium containing a monovalent alcohol having 1 to 4 carbon atoms and a solubility of the hyaluronan powder of less than 0.1 g/L to cause a crosslinking reaction. Also, the swellable crosslinked hyaluronan powder produced by the method has a swelling ratio in water of 500% or more.Type: GrantFiled: September 26, 2008Date of Patent: April 8, 2014Assignee: Shiseido Company, Ltd.Inventor: Tetsunori Matsumoto
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Patent number: 8686132Abstract: The present invention relates to a process for preparing a chemically modified polysaccharide, preferably starch, by using a microdevice. It further relates to the use of a microdevice for the chemical reactions of polysaccharides in heterogeneous mixtures. Examples of chemical modifications are acetylation, oxidation, hydroxypropylation and the like.Type: GrantFiled: August 19, 2010Date of Patent: April 1, 2014Assignee: Cargill, IncorporatedInventors: Marc Charles Florent Berckmans, Rita Maria Delrue, Bruno Frédéric Stengel
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Patent number: 8680264Abstract: A method for converting a carbohydrate to a furan in a polar aprotic solvent in the presence of a chloride, bromide, or iodide salt or a mixture thereof and optionally in the presence of an acid catalyst, a metal halide catalyst and/or an ionic liquid (up to 40 wt %). The method can be employed in particular to produce furfural or 5-hydroxymethylfurfural.Type: GrantFiled: October 30, 2012Date of Patent: March 25, 2014Assignee: Wisconsin Alumni Research FoundationInventors: Joseph Bartholomew Binder, Ronald Thaddeus Raines
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Patent number: 8673864Abstract: The present invention provides a mangiferin-berberine salt and manufacturing method thereof. Otherwise, the present invention also provides the use of mangiferin-berberine salt as AMPK activator.Type: GrantFiled: June 3, 2010Date of Patent: March 18, 2014Assignee: Hainan Deze Drug Research Co., Ltd.Inventors: Houlei Teng, Wei Wu
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Patent number: 8648146Abstract: Disclosed is a method for activating a solid support material with epoxy groups and for immobilizing ligands thereon, utilizing phase transfer catalytic conditions. The method permits the introduction of epoxy groups and specific nucleophilic ligands on the support material with a high level of substitution. Furthermore, the invention provides a general method for immobilizing a ligand for use in a wide variety of chromatographic separation procedures such as ion exchange chromatography, hydrophobic interaction chromatography (HIC), reverse phase chromatography (RPC), or affinity chromatography.Type: GrantFiled: June 6, 2012Date of Patent: February 11, 2014Assignee: GE Healthcare Bio-Sciences ABInventors: Gunnar Glad, Jean-Luc Maloisel, Nicolas Thevenin
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Patent number: 8637661Abstract: A process is described for the preparation of water-soluble cellulose hydrolysis product. The process comprise admixing cellulose with an ionic liquid capable of solvating or dissolving at least some of the cellulose, said ionic liquid being a compound comprises solely of cations and anions and which exists in a liquid state at a temperature at or below 150° C., and in which the anions are selected from halide and cyanate; and treating the resulting solvate or solution with an acid in the presence of water, said acid having a pKa in water of less than 2 at 25° C.Type: GrantFiled: October 11, 2012Date of Patent: January 28, 2014Assignee: Petroliam Nasional BerhadInventors: Markus Fanselow, John Holbrey, Kenneth Richard Seddon
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Patent number: 8637284Abstract: Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids.Type: GrantFiled: December 6, 2011Date of Patent: January 28, 2014Assignee: Xyleco, Inc.Inventor: Marshall Medoff
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Patent number: 8637660Abstract: A process for the preparation of water-soluble cellulose hydrolysis products, which comprises admixing cellulose with an ionic liquid in which the cellulose has at least some solubility, said ionic liquid state at a temperature at or below 150 -C, and treating the resulting solution with an acid in the presence of water, said acid having a pKa in water of less than 2 at 25 -C.Type: GrantFiled: May 18, 2007Date of Patent: January 28, 2014Assignee: Petroliam Nasional BerhadInventors: Markus Fanselow, John Holbrey, Kenneth Richard Seddon
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Patent number: 8629267Abstract: A method for producing starch hydrolysate that includes processing in a high shear device a hydrolytic solution having a component selected from the group consisting of acids, hydrolytic enzymes, and combinations thereof, and an aqueous starch solution to produce a dispersion, wherein the high shear device is configured with a rotor and a stator; and transferring the dispersion from the high shear device to a reactor from which a starch hydrolysate product comprising dextrose is removed, wherein the operating temperature within the reactor is maintained at a temperature of less than about 160° C.Type: GrantFiled: August 13, 2012Date of Patent: January 14, 2014Assignee: H R D CorporationInventors: Abbas Hassan, Ebrahim Bagherzadeh, Rayford G. Anthony, Gregory Borsinger, Aziz Hassan
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Patent number: 8629266Abstract: Starch-based dextrin adhesive additives and methods of preparation are described. Adhesives containing the additive exhibit antimicrobial properties and increased water solubility. The additive contains at least one sugar unit, at least one polyphenol side chain, and at least one Frechet-type poly(aryl ether)dendron.Type: GrantFiled: October 12, 2012Date of Patent: January 14, 2014Assignee: Empire Technology Development LLCInventor: Glen Leon Brizius
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Patent number: 8618266Abstract: The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).Type: GrantFiled: March 11, 2005Date of Patent: December 31, 2013Assignee: Fresenius Kabi Deutschland GmbHInventors: Harald S. Conradt, Eckart Grabenhorst, Manfred Nimtz, Norbert Zander, Ronald Frank, Wolfram Eichner
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Patent number: 8618067Abstract: Disclosed is L-glucose monohydrate and compositions thereof. Also disclosed are methods for making L-glucose monohydrate and compositions thereof. Further disclosed are methods for colonic cleansing using L-sugars, such as L-glucose monohydrate, and compositions and kits useful for colonic cleansing.Type: GrantFiled: June 3, 2010Date of Patent: December 31, 2013Assignee: Aptalis Pharma US, Inc.Inventors: Michael Caswell, Edward Delaney, Mohammad Rahman
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Patent number: 8609834Abstract: The present invention discloses a method of synthesizing sucrose-6-acetic ester, comprising the following steps: adding sucrose into a polar aprotic solvent, and stirring the solvent to dissolve it, then generate a suspension solution of sucrose; adding a acetylation agent acetylnitrile into said suspension solution and stirring the solution; adding water into the aforesaid reaction solution, and then concentrating it to generate a concentrated product; adding a crystalline solvent into the concentrated product, stirring to dissolve it, and depositing for crystallization, then filtering and drying it to get a product of sucrose-6-acetic ester. The benefit of the present invention is that the method of synthesizing sucrose-6-acetic ester has simple operation, mild reaction condition, high selectivity, high yield, and is suitable for industrial production.Type: GrantFiled: November 8, 2007Date of Patent: December 17, 2013Assignee: Shenzhen New Trend Industrial Development Co. Ltd.Inventor: Xiaoqiang Wang
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Publication number: 20130324464Abstract: Disclosed are an aryl glycoside compound as represented by formula I or formular I?, a pharmaceutically acceptable salt thereof, optical isomer thereof or a prodrug thereof. The present invention relates to a method of preparing said aryl glycoside compound and the use thereof The aryl glycoside compound of the present invention has an excellent ability on inhibit SGLT activity, especially SGLT2 activity, and is diabetes-fighting medicine with great potential.Type: ApplicationFiled: February 17, 2012Publication date: December 5, 2013Applicants: SHANGHAI CHEMPARTNER CO., LTD, SHANGHAI YINGLI SCIENCE AND TECHNOLOGY CO., LTDInventors: Zusheng Xu, Su Qian
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Patent number: 8586562Abstract: The present specification discloses fluid compositions comprising a matrix polymer and stabilizing component, methods of making such fluid compositions, and methods of treating skin conditions in an individual using such fluid compositions.Type: GrantFiled: May 10, 2010Date of Patent: November 19, 2013Assignee: Allergan Industrie, SASInventor: Pierre F. Lebreton
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Publication number: 20130303742Abstract: The present invention relates to a process for generating glucose and glucose derivatives from the direct contacting of cellulose, hemicelluloses and/or polysaccharides with a mixed super critical fluid system of alcohol and water whereby the partial pressure of the system provides for both alcoholysis and hydrolysis of the material to generate primarily glucose, and glucose derivatives.Type: ApplicationFiled: November 1, 2011Publication date: November 14, 2013Inventors: William Rusty Sutterlin, Mark G. Tegen, William Berry
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Patent number: 8580952Abstract: A glyoxal and boron free purified cationic polygalactomannan may be prepared by reacting a polygalactomannan flour, a nonionically derivatized polygalactomannan flour, or a mixture thereof, with a cationising reagent, adjusting the pH to be from about 4 to about 6; cross-linking the cationic with glyoxal, and filtering and water washing the cationic polygalactomannan to produce a glyoxalated purified cationic polygalactomannan containing not more than 70% by weight of water. In some cases it may be desirable to introduce a buffering agent to the glyoxalated purified cationic polygalactomannan to regulate the pH to from 8.0 to about 9.5, when measured at 1% (dry matter) in water. In other cases, it may be desirable to remove water to produce glyoxal free purified cationic polygalactomannan in powder form. Such compounds are particularly useful in personal care products.Type: GrantFiled: January 7, 2011Date of Patent: November 12, 2013Assignee: Lamberti SpAInventors: Ugo Pfeiffer, Mauro Tenconi, Eva Baldaro, Valentina Langella, Giovanni Floridi, Giuseppe Li Bassi
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Patent number: 8575129Abstract: An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R=NR6R7, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O—, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R1, R2, R3, R4=H, SO3—, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, —CO—(CH2)2—COOY; Y=negative charge, or H; R5=—CO—CH3, H, SO3—, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R6=is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R7=is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or R5 forms an amide group.Type: GrantFiled: November 20, 2009Date of Patent: November 5, 2013Assignee: Fidia Farmaceutici S.p.A.Inventors: Davide Bellini, Alessandra Topai
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Publication number: 20130289268Abstract: This invention is directed to a process for treating biomass. The biomass is treated with a biomass swelling agent within the vessel to swell or rupture at least a portion of the biomass. A portion of the swelling agent is removed from a first end of the vessel following the treatment. Then steam is introduced into a second end of the vessel different from the first end to further remove swelling agent from the vessel in such a manner that the swelling agent exits the vessel at a relatively low water content.Type: ApplicationFiled: April 27, 2012Publication date: October 31, 2013Applicant: MBI INTERNATIONALInventors: Farzaneh Teymouri, Timothy J. Campbell
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Patent number: 8569467Abstract: The invention relates to C-glycose compounds of formula (I) where: S? is a monosaccharide radical or a polysaccharide radical derived from a monosaccharide or polysaccharide S; R is a linear or branched alkyl radical; and Z is an ethylenyl CH?CR1(R2) or an acetylenyl C?CR3 radical. The invention also relates to a method for preparing C-glycoside compounds of formula (III), characterized in that the method consists of a step of reacting a sugar (S), in an aqueous solvent or in the absence of a solvent and in the presence of an organic or mineral base (B), with a phosphonate of formula (II) according to the following reaction pattern: Formulas (II), (III).Type: GrantFiled: November 6, 2009Date of Patent: October 29, 2013Assignees: Ecole Nationale Supérieure de Chimie de Rennes, Armor ProteinesInventors: Thierry Benvegnu, Loïc Lemlegre, Adeline Ranoux
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Patent number: 8569479Abstract: A process for reducing the average molecular weight of a cellulose ether comprises the step of contacting a cellulose ether with an acid to partially depolymerize it to a lower molecular weight in a diluent comprising at least 50 weight percent of an organic hydroxylic compound having at least one hydroxy group and at least two carbon atoms.Type: GrantFiled: April 23, 2007Date of Patent: October 29, 2013Assignee: Dow Global Technologies, LLCInventor: Charles B. Mallon
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Publication number: 20130281688Abstract: Unsaturated alcohol compositions are obtained by reducing a metathesis-derived hydrocarbyl unsaturated ester. Also disclosed is a process for preparing an unsaturated alcohol composition, where a metathesis derived hydrocarbyl carbonyl compound is reacted in the presence of a silane compound, an organic solvent, and a catalyst system prepared from a metallic complex and a reducing agent. This mixture is then hydrolyzed with a metallic base, and then mixed with organic solvent. The resultant mixture is then separated, washed, dried, and/or purified to produce the unsaturated alcohol composition. The unsaturated alcohol derivatives are useful in many end-use applications, including, for example, lubricants, functional fluids, fuels, functional additives for such lubricants, functional fluids and fuels, plasticizers, asphalt additives, friction reducing agents, plastics, and adhesives.Type: ApplicationFiled: April 22, 2013Publication date: October 24, 2013Applicant: Elevance Renewable Sciences, IncInventors: Stephen A. Di Biase, Keith M. Wampler, David R. Allen, Randal J. Bernhardt, Ryan Littich
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Patent number: 8552177Abstract: A method for making functionalized porous crosslinked polysaccharide gel coated structures used as liquid chromatography media is provided. The method includes impregnating a porous substrate with a room temperature stable aqueous polysaccharide solution containing water, 0.1% to 20% of a polysaccharide, 18% to 54% of a gel-inhibiting agent to prevent the gel from re-gelling, and 0.001% to 10% of an anionic fluorosurfactant for optimum solution coatability onto the substrate, each concentration is by total weight of the aqueous solution. Next water is evaporated from the coating, followed by exposing the dehydrated coating to a gelling agent thereby forming a porous polysaccharide gel coated substrate. Next the gel coated substrate is exposed to a crosslinking agent forming a porous crosslinked polysaccharide gel coated substrate.Type: GrantFiled: August 30, 2011Date of Patent: October 8, 2013Assignee: EMD Millipore CorporationInventors: Wilson Moya, Neil P. Soice
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Patent number: 8552164Abstract: The invention relates to a novel method for production of nanofibrillar chitin, sustainable from an industrial manufacturing standpoint and suitable for producing chitin nanofibrils having improved properties and free from less crystalline components. The invention also relates to novel chitin nanofibrils obtained with said method and characterized by an increased dispersibility in aqueous media. The invention further relates to uses of nanofibrils in pastes and aqueous gels useful for topical on-skin application, to the manufacturing of materials of biomedical interest, as well as to the deposition of chitin nanofibrils on coating surfaces or the incorporation of the same inside of items like, e.g., fibers and fabrics of any Origin, natural as well as synthetic or mixed ones.Type: GrantFiled: November 23, 2006Date of Patent: October 8, 2013Assignee: Mavi Sud S.r.l.Inventors: Pierfrancesco Morganti, Corrado Muzzarelli
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Patent number: 8546561Abstract: Methods of making glucose and/or furfural from biomass require one or more supercritical fluids that may be used to process biomass, cellulose from the biomass, and/or xylose from the biomass. Examples of supercritical fluids for use in processing biomass include ethanol, water, and carbon dioxide at a temperature and pressure above the critical points for ethanol and carbon dioxide but at a temperature and/or pressure below that of the critical point for water. A supercritical fluid containing carbon dioxide and water may be used to convert cellulose to glucose or convert xylose to furfural. The fluid has a temperature and pressure above the critical point of carbon dioxide, but at least one of the temperature and pressure is below the critical point for water.Type: GrantFiled: July 16, 2009Date of Patent: October 1, 2013Assignee: Renmatix, Inc.Inventor: Srinivas Kilambi
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Patent number: 8546560Abstract: The invention relates to a process for hydrolyzing cellulose, comprising: (a) contacting cellulose with a fluid mixture comprising supercritical CO2 and sub-critical or near-critical water to form a reactant mixture at a first temperature and first pressure for a first time period, wherein a reaction occurs and forms one or more hydrolysis products; (b) quenching the reaction; and (c) recovering at least one hydrolysis product.Type: GrantFiled: July 16, 2009Date of Patent: October 1, 2013Assignee: Renmatix, Inc.Inventor: Srinivas Kilambi
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Patent number: 8541571Abstract: The invention is directed to a simple and new method for the homogeneous synthesis of cellulose ethers. Ionic liquids are not only used as solvent, but also as reaction media for the homogeneous etherification of cellulose. The dissolved cellulose is treated with the etherification agent in the absence of organic and/or inorganic bases and in the absence and/or in the presence of moderate amounts of water. The obtained cellulose ethers show new distributions of substitution on the polymer chain, resulting in new properties and applications.Type: GrantFiled: February 25, 2009Date of Patent: September 24, 2013Assignee: SE Tylose GmbH & Co. KGInventors: Eugen Moellmann, Thomas Heinze, Tim Liebert, Sarah Koehler
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Patent number: 8541567Abstract: Provided are methods of designing a putative inhibitor of a 5?-methylthioadenosine/S-adenosylhomocysteine nucleosidase. The methods comprise designing a chemically stable compound that resembles the charge and geometry of the 5?-methylthioadenosine/S-adenosylhomocysteine nucleosidase transition state. Also provided are methods of inhibiting 5?-methylthioadenosine/S-adenosylhomocysteine nucleosidases using the inhibitors found by the above methods.Type: GrantFiled: July 26, 2006Date of Patent: September 24, 2013Assignee: Albert Einstein College of Medicine of Yeshiva UniversityInventor: Vern L. Schramm
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Publication number: 20130245252Abstract: A process is disclosed for conversion of cellulose in an Ionic Liquid medium. The process is characterized in that a cellulose-containing feedstock and an Ionic Liquid are mixed at a temperature below 80 ° C. The mixture is heated to a conversion temperature in the range of 80 ° C. to 220 ° C. under a hydrogen atmosphere. The presence of hydrogen during the heating step significantly reduces the formation of degradation products.Type: ApplicationFiled: March 4, 2013Publication date: September 19, 2013Applicants: Petroleo Brasileiro S.A. - PetrobrasInventors: Michiel MAKKEE, Jacob Adriaan MOULIJN, Jianrong LI, Paul O'CONNOR, Jacobus Cornelis RASSER, Armand Eduard ROSHEUVEL, Rafael MENEGASSI DE ALMEIDA
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Publication number: 20130245250Abstract: Method for producing L-fucose includes in a first aspect, a method for the preparation of L-fucose, wherein L-fucose precursors are produced from pectin and L-fucose is produced from the L-fucose precursors; in a second aspect, a method for the preparation of L-fucose from D-galacturonic acid or a salt thereof, wherein L-fucose precursors are produced from D-galacturonic acid of a salt thereof, and L-fucose is produced from the L-fucose precursors; and an L-fucose precursor as shown in Formula A, wherein R is a linear or branched chain saturated hydrocarbon group with 1-6 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, n-hexyl, etc., preferably a methyl group.Type: ApplicationFiled: October 13, 2011Publication date: September 19, 2013Applicant: GLYCOM A/SInventors: Andreas Schroven, Gyula Dekany, Christoph Röhrig, Ioannis Vrasidas, Ignacio Figueroa Pérez, Markus Hederos, Julien Boutet, Lars Kröger, Piroska Kovács-Pénzes, Ferenc Horváth, Christian Risinger, Gergely Pipa
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Mixed butyric-formic esters of acid polysaccharides, and their preparation and use as skin cosmetics
Patent number: 8530450Abstract: Disclosed are acid polysaccharides characterized by the concomitant presence of alcohol groups esterified with butyric and formic acids.Type: GrantFiled: November 20, 2008Date of Patent: September 10, 2013Assignee: Sigea S.R.L.Inventors: Marco Bosco, Luca Stucchi, Rita Gianni, Antonia Trevisan -
Patent number: 8524889Abstract: An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-?-maltosyl- and/or 6-?-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.Type: GrantFiled: April 10, 2012Date of Patent: September 3, 2013Assignee: Hayashibara Co., Ltd.Inventors: Tomoyuki Nishimoto, Katsuhiko Hino, Takanori Okura, Hiroto Chaen, Shigeharu Fukuda, Toshio Miyake
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Patent number: 8524885Abstract: Disclosed are chemically modified hyaluronic acid (HA) derivatives containing hydrazido groups directly linked to the glucuronic acid residues of HA. Said hydrazido groups are used to obtain crosslinked and labeled HA derivatives. The invention further relates to methods of preparation of said HA derivatives.Type: GrantFiled: March 6, 2007Date of Patent: September 3, 2013Assignees: Prochon Biotech Ltd., Bio-Technology General (Israel) Ltd.Inventors: Boaz Amit, Avraham Wortzel, Avner Yayon
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Patent number: 8524887Abstract: This invention relates a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate and processes to produce the cellulose solution. Another aspect of this invention relates to shaped articles prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising derivatives of cellulose prepared from a cellulose solution comprising at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising regioselectively substituted cellulose esters prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. In another embodiment of the invention, the cellulose esters of the present invention are used as protective and compensation films for liquid crystalline displays.Type: GrantFiled: August 12, 2009Date of Patent: September 3, 2013Assignee: Eastman Chemical CompanyInventors: Charles Michael Buchanan, Norma Lindsey Buchanan, Elizabeth Guzman-Morales
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Patent number: 8507660Abstract: A novel N-acetyl-5-N,4-O-carbonyl-protected dibutyl sialyl phosphate donor for sialylation of both primary and sterically hindered secondary acceptors to prepare sialosides with high yield and ?-selectivity is disclosed. Methods for making disaccharide building blocks comprising ?(2?3), ?(2?6), ?(2?8), ?(2?8)/?(2?9) alternate, and ?(2?9) sialosides are provided. methods for one-pot synthesis of complex sialosides are disclosed. Libraries of sialosides and methods for using the libraries for detection and receptor binding analysis of surface glycoproteins or pathogens and cancer cells are disclosed. Methods for distinguishing between hemagglutinin (HA) from various strains of influenza are provided.Type: GrantFiled: March 29, 2010Date of Patent: August 13, 2013Assignee: Academia SinicaInventors: Chi-Huey Wong, Ting-Jen Rachel Cheng, Chung-Yi Wu
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Patent number: 8507666Abstract: Disclosed herein are methods for modifying carbohydrates using hydroxyl radicals. The hydroxyl radicals may be formed by the photolysis of peroxide in aqueous solution using UV light. Also disclosed are compositions and products comprising carbohydrates modified by the process.Type: GrantFiled: August 24, 2010Date of Patent: August 13, 2013Assignee: Corn Products Development, Inc.Inventor: Roman Skuratowicz
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Publication number: 20130205439Abstract: Methods for the production of an intergeneric hybrid plants and plants produced thereby. In certain aspects, intergeneric hybrid plants are produced by crossing a sorghum parent plant comprising a mutant sorghum iap allele with a second moncot plant. Methods for the use of such plants and products obtained therefrom are also provided.Type: ApplicationFiled: January 25, 2013Publication date: August 8, 2013Applicant: The Texas A&M University SystemInventor: The Texas A&M University System
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Patent number: 8501932Abstract: Procedure for the preparation of cationic guar having DS comprised between 0.01 and 3, free from boron and suitable for the use in the cosmetic field and in household cleaning products, comprising the following steps: a) 100 parts by weight of guar flour are reacted with 3-chloro-2-hydroxypropyl trimethylammonium chloride and sodium hydroxide in from 5 to 500 parts by weight of a water and alcohol mixture containing from 20 to 50% by weight of water; b) the amount of water and alcohol is regulated in order to obtain a dispersion containing from 65 to 95% by weight of a of water and alcohol mixture containing from 30 to 50% by weight of water and the dispersion is maintained under stirring at temperature comprised between 15 and 40° C. for at least 10 minutes; c) the mixture is filtered under vacuum and dried to obtain the purified cationic guar.Type: GrantFiled: April 17, 2007Date of Patent: August 6, 2013Assignee: Lamberti SPAInventors: Eva Baldaro, Raffaella Pelizzari, Mauro Tenconi, Giuseppe Li Bassi
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Publication number: 20130197213Abstract: Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1?, and 6? positions, with irreversible removal of HCl formed during the reaction to form the chlorinated carbohydrate or derivative thereof, for example, a 4,1?,6?-trichloro-4,1?,6?-trideoxy-6-O-ester of galactosucrose (TGS-6E). The irreversible removal of HCl can be carried out by an irreversible physical process and/or an irreversible chemical process. Sucralose, an artificial sweetener, can be prepared by deesterification of the TGS-6E. The chlorination reaction takes place at low temperatures and the desired chlorinated product is obtained in high yields and in high purities.Type: ApplicationFiled: March 14, 2013Publication date: August 1, 2013Applicant: LEXINGTON PHARMACEUTICALS LABORATORIES, LLCInventor: Lexington Pharmaceuticals Laboratories, LLC
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Patent number: 8497367Abstract: A process for the extraction of sucralose from an aqueous solution containing at least sucralose, other chlorinated saccharides, sodium chloride and dimethylammonium chloride into an organic solvent for sucralose by contacting said organic solvent with said solution to extract sucralose into the organic solvent. The ratio of sodium chloride to dimethylammonium chloride in the aqueous solution is increased prior to or during contact so as to increase the partition coefficient of sucralose into said organic solvent.Type: GrantFiled: March 30, 2009Date of Patent: July 30, 2013Assignee: Tate & Lyle Technology LimitedInventors: Robert Jansen, Gordon Walker, John Kerr, Anthony Baiada
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Patent number: 8492539Abstract: The present invention provides (i) processes for preparing a 2?-deoxy-2?-fluoro-2?-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2?-deoxy-2?-fluoro-2?-C-methyl-?-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.Type: GrantFiled: September 13, 2005Date of Patent: July 23, 2013Assignee: Gilead Pharmasset LLCInventors: Byoung-Kwon Chun, Peiyuan Wang, Jinfa Du, Suguna Rachakonda
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Publication number: 20130178617Abstract: Methods and catalyst compositions for formation of furans from carbohydrates. A carbohydrate substrate is heating in the presence of a 2-substituted phenylboronic acid (or salt or hydrate thereof) and optionally a magnesium or calcium halide salt. The reaction is carried out in a polar aprotic solvent other than an ionic liquid, an ionic liquid or a mixture thereof. Additional of a selected amount of water to the reaction can enhance the yield of furans.Type: ApplicationFiled: September 27, 2012Publication date: July 11, 2013Inventors: Ronald Raines, Benjamin Caes, Michael Palte
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Patent number: 8481718Abstract: A gel manufactured by irradiating ionizing radiation in the range of 5-1000 kGy to an obtained paste compound of a density of 10% by weight or more after adding water to carboxymethyl carrageenan and wherein each gram of dry gel obtained is capable of absorbing 20 grams or more of water. The ionizing radiation may be gamma rays, electron beams or X-rays.Type: GrantFiled: December 4, 2007Date of Patent: July 9, 2013Assignee: Japan Atomic Energy AgencyInventors: Toshiaki Yagi, Naotsugu Nagasawa, Akihiro Hiroki, Masao Tamada, Charito T. Aranilla
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Patent number: 8481713Abstract: The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-?-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.Type: GrantFiled: May 25, 2010Date of Patent: July 9, 2013Assignee: Gilead Pharmasset LLCInventors: Peiyuan Wang, Wojciech Stec, Byoung Kwon Chun, Junxing Shi, Jinfa Du
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Patent number: 8481695Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: GrantFiled: August 13, 2010Date of Patent: July 9, 2013Assignee: FMC Biopolymer ASInventors: Jan Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid B. Berge, Terje Svendsen
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Patent number: 8481719Abstract: After adding water to the carboxymethyl carrageenan which is raw material and mixing them well, the ionizing radiation of more than fixed dose is irradiated to the obtained paste sample of fixed concentration. As a result, an excellent hydrogel in heat resistance which does not dissolve at 50° C. or more can be obtained. The manufactured gel can be used for many kinds of products. Because this gel has a biodegradation characteristic, it is possible to dispose by composting.Type: GrantFiled: August 23, 2010Date of Patent: July 9, 2013Assignee: Japan Atomic Energy AgencyInventors: Toshiaki Yagi, Naotsugu Nagasawa, Akihiro Hiroki, Masao Tamada, Charito T. Aranilla
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Patent number: 8475765Abstract: The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (I) at its reducing end which is not oxidized prior to said reaction, with a compound of formula (II) R?NH—R? (II) wherein R1-R2 and R3 are independently hydrogen or a linear or branched hydroxyalkyl group, and wherein either R? or R? or R? and R? comprise at least one functional group X capable of being reacted with at least one other compound prior to or after the reaction of (I) and (II), as well as to the hydroxyalkyl starch derivative as such, obtainable by said method, and to a pharmaceutical composition comprising said hydroxyalkyl starch derivative.Type: GrantFiled: August 12, 2010Date of Patent: July 2, 2013Assignee: Fresenius Kabi Deutschland GmbHInventors: Norbert Zander, Harald Conradt, Wolfram Eichner