Patents by Inventor Mingde Xia

Mingde Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED SALICYLAMIDE COMPOUNDS AND USE THEREOF
    Publication number: 20240092737
    Abstract: Provided is a compound or a pharmaceutically acceptable salt, prodrug, or metabolite thereof, or a solvate or hydrate of any of the foregoing and a use in treatment of a disease or disorder.
    Type: Application
    Filed: January 10, 2022
    Publication date: March 21, 2024
    Applicant: HELIOS HUAMING BIOPHARMA CO., LTD.
    Inventors: Yanming WANG, Yan XIA, Zhengwei GUO, Jinquan SUN, Mingde XIA
  • SUBSTITUTED HETEROARYL COMPOUNDS AND USE THEREOF
    Publication number: 20230381146
    Abstract: The present disclosure provides substituted heteroaryl compounds and use thereof, also provides compounds or pharmaceutically acceptable salts or solvates thereof as PAD inhibitors and their use in treatment of a disease or disorder.
    Type: Application
    Filed: October 11, 2021
    Publication date: November 30, 2023
    Applicant: HELIOS HUAMING BIOPHARMA CO., LTD.
    Inventors: Yanming WANG, Yan XIA, Jinquan SUN, Mingde XIA
  • Benzimidazole derivatives useful TRPM8 channel modulators
    Patent number: 9636345
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: May 2, 2017
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: Mark J. Macielag, Mingde Xia, Xiaoqing Xu
  • Cold menthol receptor antagonists
    Patent number: 9096521
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4, and R5 are defined herein.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: August 4, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Raymond W Colburn, Scott L Dax, Christopher M Flores, Donald W Ludovici, Mingde Xia, Xiaoqing Xu, Mark A Youngman, Bin Zhu
  • Imidazo[1,2-?]pyridine sulfonamides as TRPM8 modulators
    Patent number: 9067935
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: June 30, 2015
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Mark J Macielag, Mingde Xia, James J McNally, Jay M Matthews
  • BENZIMIDAZOLE DERIVATIVES USEFUL TRPM8 CHANNEL MODULATORS
    Publication number: 20150150882
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Application
    Filed: February 10, 2015
    Publication date: June 4, 2015
    Inventors: Mark J. Macielag, Mingde Xia, Xiaoqing Xu
  • Benzimidazole derivatives useful as TRPM8 channel modulators
    Patent number: 8981113
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: March 17, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Mark J Macielag, Mingde Xia, Xiaoqing Xu
  • COLD MENTHOL RECEPTOR ANTAGONISTS
    Publication number: 20140128428
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4, and R5 are defined herein.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 8, 2014
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu
  • IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20140088098
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 27, 2014
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, James J. McNally, Jay M. Matthews
  • Cold menthol receptor antagonists
    Patent number: 8653099
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4 and R5 are defined herein.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: February 18, 2014
    Assignee: Janssen Pharmaceutica
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu
  • Imidazo[1,2-?]pyridine sulfonamides as TRPM8 modulators
    Patent number: 8618150
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: December 31, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, James J. McNally, Jay M. Matthews
  • BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS
    Publication number: 20130245085
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Application
    Filed: April 30, 2013
    Publication date: September 19, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, Xiaoqing Xu
  • Benzimidazole derivatives useful as TRPM8 channel modulators
    Patent number: 8450497
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: May 28, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, Xiaoqing Xu
  • Hexahydro-cycloheptapyrazole cannabinoid modulators
    Patent number: 8378117
    Abstract: This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: February 19, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Fina Liotta, Mingde Xia, Huajun Lu, Meng Pan, Michael P. Wachter, Mark J. Macielag
  • Hexahydro-cycloheptapyrazole cannabinoid modulators
    Patent number: 8378096
    Abstract: This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: February 19, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Fina Liotta, Mingde Xia, Huajun Lu, Meng Pan, Michael P. Wachter
  • Cold menthol receptor antagonists
    Patent number: 8324217
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: December 4, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Jay M. Matthews, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu
  • Benzimidazole derivatives useful as TRPM8 channel modulators
    Patent number: 8242157
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: August 14, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michele C. Jetter, Mark J. Macielag, Mingde Xia, Xiaoqing Xu
  • IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20120149699
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Inventors: Mark J. Macielag, Mingde Xia, James J. McNally, Jay M. Matthews
  • COLD MENTHOL RECEPTOR ANTAGONISTS
    Publication number: 20120136006
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.
    Type: Application
    Filed: February 6, 2012
    Publication date: May 31, 2012
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Jay M. Matthews, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu
  • Cold menthol receptor antagonists
    Patent number: 8143259
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: March 27, 2012
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Jay M. Matthews, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu